Abstract
Purpose of Review
Although medical and surgical practice has changed over time, airway complications after lung transplantation still occur with relative frequency. Significant confusion exists in the nomenclature, classification, grading, and management of this condition. This article aims to consolidate the latest data on this topic for the past few years.
Recent Findings
As the acuity of lung transplant candidates increases, it is important to recognize that some recipient factors such as age and prolonged mechanical ventilation are increasingly more common but are associated with anastomotic complications. Novel techniques such as ex vivo lung perfusion may also be associated. The shortened donor bronchial segment poses challenges to endobronchial interventions, especially stenting. Bifurcated mainstem stents, 3D printed stents, and biodegradable stents are a few more recent developments in this arena.
Summary
Appropriate nomenclature, grading and classification, and management of airway complications in lung transplantation are paramount and can impact outcomes in lung transplantation significantly.
Similar content being viewed by others
Data Availability
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
Crespo MM, McCarthy DP, Hopkins PM, et al. ISHLT Consensus Statement on adult and pediatric airway complications after lung transplantation: Definitions, grading system, and therapeutics. J Heart Lung Transplant. 2018;37:548–63.
Valapour M, Lehr CJ, Schladt DP, et al. OPTN/SRTR 2021 annual data report: Lung. American Journal of Transplantation. 2023;23:S379–442.
Chambers DC, Perch M, Zuckermann A, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult lung transplantation report—2021; focus on recipient characteristics. J Heart Lung Transplant. 2021;40:1060–72.
Bos S, Vos R, Van Raemdonck DE, Verleden GM. Survival in adult lung transplantation: Where are we in 2020. Current Opinion in Organ Transplantation. 2020;25:268–73.
Murthy SC, Blackstone EH, Gildea TR, et al. Impact of anastomotic airway complications after lung transplantation. Ann Thorac Surg. 2007;84(401–9):409.e1.
•• Crespo MM. Airway complications in lung transplantation. J Thorac Dis. 2021;13:6717-6724. Excellent review of the International Society of Heart and Lung Transplantation Consensus Classification and Definitions.
Awori Hayanga JW, Aboagye JK, Shigemura N, et al. Airway complications after lung transplantation: Contemporary survival and outcomes. J Heart Lung Transplant. 2016;35:1206–11.
Mahajan AK, Folch E, Khandhar SJ, et al. The diagnosis and management of airway complications following lung transplantation. Chest. 2017;152:627–38.
Delbove A, Senage T, Gazengel P, et al. Incidence and risk factors of anastomotic complications after lung transplantation. Ther Adv Respir Dis. 2022;16:17534666221110354.
Van De Wauwer C, Van Raemdonck D, Verleden GM, et al. Risk factors for airway complications within the first year after lung transplantation. Eur J Cardiothorac Surg. 2007;31:703–10.
Grimm JC, Valero V, Kilic A, et al. Association between prolonged graft ischemia and primary graft failure or survival following lung transplantation. JAMA Surg. 2015;150:547–53.
Nęcki M, Gawęda M, Pandel A, et al. Microbiological status as a factor of airway complications after lung transplantation. Transplant Proc. 2020;52:2149–54.
Groetzner J, Kur F, Spelsberg F, et al. Airway anastomosis complications in de novo lung transplantation with sirolimus-based immunosuppression. J Heart Lung Transplant. 2004;23:632–8.
Okada Y, Kondo T. Preservation solution for lung transplantation. Gen Thorac Cardiovasc Surg. 2009.
Chen CZ, Gallagher RC, Ardery P, Dyckman W, Donabue S, Low HB. Retrograde flush and cold storage for twenty-two to twenty-five hours lung preservation with and without prostaglandin E1. J Heart Lung Transplant. 1997;16:658–66.
Weder W, Inci I, Korom S, et al. Airway complications after lung transplantation: Risk factors, prevention and outcome. Eur J Cardiothorac Surg. 2009;35:293-8; discussion 298.
Garfein ES, Ginsberg ME, Gorenstein L, McGregor CC, Schulman LL. Superiority of end-to-end versus telescoped bronchial anastomosis in single lung transplantation for pulmonary emphysema. J Thorac Cardiovasc Surg. 2001;121:149–54.
Mulligan MS. Endoscopic management of airway complications after lung transplantation. Chest Surgery Clinics of North America. 2001;11:907–15.
Levy J, Kashem A, Sunagawa G, et al. Postoperative bronchial complications after lung transplantation related to anastomosis suture. Ann Thorac Surg. 2022;114:293–300.
Yserbyt J, Dooms C, Vos R, Dupont LJ, Van Raemdonck DE, Verleden GM. Anastomotic airway complications after lung transplantation: Risk factors, treatment modalities and outcome—a single-centre experience. Eur J Cardiothorac Surg. 2016;49:e1-8.
De Oliveira NC, Osaki S, Maloney JD, et al. Lung transplantation with donation after cardiac death donors: Long-term follow-up in a single center. J Thorac Cardiovasc Surg. 2010;139:1306–15.
Noda K, Chan EG, Furukawa M, et al. Single-center experience of ex vivo lung perfusion and subsequent lung transplantation. Clin Transplant. 2023;37: e14901.
Couraud L, Nashef SA, Nicolini P, Jougon J. Classification of airway anastomotic healing. Eur J Cardiothorac Surg. 1992;6:496–7.
Shennib H, Massard G. Airway complications in lung transplantation. Ann Thorac Surg. 1994;57:506–11.
Chhajed PN, Tamm M, Glanville AR. Role of flexible bronchoscopy in lung transplantation. Semin Respir Crit Care Med. 2004;25:413–23.
Santacruz JF, Mehta AC. Airway complications and management after lung transplantation: Ischemia, dehiscence, and stenosis. Proc Am Thorac Soc. 2009;6:79–93.
Moreno P, Alvarez A, Algar FJ, et al. Incidence, management and clinical outcomes of patients with airway complications following lung transplantation. Eur J Cardiothorac Surg. 2008;34:1198–205.
• Muñoz-Fos A, Moreno P, González FJ, et al. Airway complications after lung transplantation—a contemporary series of 400 bronchial anastomoses from a single center. J Clin Med. 2023;12:3061. A more recent series on anastomotic complications after the new consensus classifications were released.
Usuda K, Gildea TR, Pandya C, Mehta AC. Bronchial dehiscence. Journal of Bronchology & Interventional Pulmonology. 2005;12:164–5.
Garfein ES, McGregor CC, Galantowicz ME, Schulman LL. Deleterious effects of telescoped bronchial anastomosis in single and bilateral lung transplantation. Ann Transplant. 2000;5:5–11.
Bin Saeedan M, Rizk A, Yadav R, Ghosh S. Imaging evaluation of airway complications after lung transplant. J Comput Assist Tomogr. 2020;44:314–27.
Mughal MM, Gildea TR, Murthy S, Pettersson G, DeCamp M, Mehta AC. Short-term deployment of self-expanding metallic stents facilitates healing of bronchial dehiscence. Am J Respir Crit Care Med. 2005;172:768–71.
Maloney JD, Weigel TL, Love RB. Endoscopic repair of bronchial dehiscence after lung transplantation. Ann Thorac Surg. 2001;72:2109–11.
Luna BW, Paoletti L, Denlinger CE, Pastis NJ, Whelan TP. Closure of a post-transplant bronchial dehiscence with endobronchial fibrin sealant. Ann Thorac Surg. 2018;106:e193–5.
Siddique A, Sabbah BN, Arabi T, et al. Treatment of bronchial anastomotic fistula using autologous platelet-rich plasma post lung transplantation. J Cardiothorac Surg. 2022;17:204.
Kumar A, Alraiyes AH, Gildea TR. Amniotic membrane graft for bronchial anastomotic dehiscence in a lung transplant recipient. Ann Am Thorac Soc. 2015;12:1583–6.
Backer E, Dincer EH, Keenan JC, Diaz-Gutierrez I, Cho RJ. Successful treatment of airway dehiscence in a lung transplant patient with radiofrequency ablation. J Bronchology Interv Pulmonol. 2020;27:e56–9.
Miyata R, Chen-Yoshikawa TF, Hamaji M, et al. Successful conservative management of an anastomotic airway dehiscence at the left main bronchus following bilateral cadaveric lung transplantation. Gen Thorac Cardiovasc Surg. 2018;66:368–71.
Ram D, Mathew G, Lewis C, et al. Lung transplant graft salvage using aortic homograft for bronchial dehiscence. Interact Cardiovasc Thorac Surg. 2020;31:664–6.
Schäfers HJ, Schäfer CM, Zink C, Haverich A, Borst HG. Surgical treatment of airway complications after lung transplantation. J Thorac Cardiovasc Surg. 1994;107:1476–80.
Hasegawa T, Iacono AT, Orons PD, Yousem SA. Segmental nonanastomotic bronchial stenosis after lung transplantation. Ann Thorac Surg. 2000;69:1020–4.
Marulli G, Loy M, Rizzardi G, et al. Surgical treatment of posttransplant bronchial stenoses: Case reports. Transplant Proc. 2007;39:1973–5.
Mazzetta A, Porzio M, Riou M, et al. Patients treated for central airway stenosis after lung transplantation have persistent airflow limitation. Ann Transplant. 2019;24:84–92.
Anzueto A, Levine SM, Tillis WP, Calhoon JH, Bryan CL. Use of the flow-volume loop in the diagnosis of bronchial stenosis after single lung transplantation. Chest. 1994;105:934–6.
Chhajed PN, Malouf MA, Tamm M, Spratt P, Glanville AR. Interventional bronchoscopy for the management of airway complications following lung transplantation. Chest. 2001;120:1894–9.
McArdle JR, Gildea TR, Mehta AC. Balloon bronchoplasty: Its indications, benefits, and complications. Journal of Bronchology & Interventional Pulmonology. 2005;12:123–7.
Zwintscher N, Koopercamp H, Gaudet M, Rampolla-Selles R, Bates MJ. Cryotherapy of airway stenosis after lung transplant. The Journal of Heart and Lung Transplantation. 2018;37:S449–50.
Moore RF, Lile DJ, Abbas AE. Current status of spray cryotherapy for airway disease. J Thorac Dis. 2017;9:S122–9.
Tremblay A, Coulter TD, Mehta AC. Modification of a mucosal-sparing technique using electrocautery and balloon dilatation in the endoscopic management of web-like benign airway stenosis. Journal of Bronchology & Interventional Pulmonology. 2003;10:268–71.
Davidson KR, Elmasri M, Wahidi MM, Shofer SL, Cheng GZ, Mahmood K. Management of lung transplant bronchial stenosis with mitomycin C. J Bronchology Interv Pulmonol. 2019;26:124–8.
Abi-Jaoudeh N, Francois RJ, Oliva VL, et al. Endobronchial dilation for the management of bronchial stenosis in patients after lung transplantation: Effect of stent placement on survival. J Vasc Interv Radiol. 2009;20:912–20.
Saad CP, Murthy S, Krizmanich G, Mehta AC. Self-expandable metallic airway stents and flexible bronchoscopy: Long-term outcomes analysis. Chest. 2003;124:1993–9.
• Sinha T, Ho TA, van der Rijst N, Lashari B, Weir M. Safety of hybrid bronchial stents in transplant airway complications: A single center experience. J Thorac Dis. 2022;14:2071-2078. Additional data clarifying the safety of hybrid bronchial stents in lung transplant airway complications.
Gottlieb J, Fuehner T, Dierich M, Wiesner O, Simon AR, Welte T. Are metallic stents really safe? A long-term analysis in lung transplant recipients. Eur Respir J. 2009;34:1417–22.
van Pel R, Gan T, Klooster K, et al. Lung transplant airway complications treated with biodegradable stents: A multi-center experience. The Journal of Heart and Lung Transplantation. 2023;42:S531.
Sethi S, Gildea TR, Almeida FA, Cicenia JC, Machuzak MS. Clinical success stenting distal bronchi for “lobar salvage” in bronchial stenosis. J Bronchology Interv Pulmonol. 2018;25:9–16.
• DiBardino DM, Andronov M, Haas AR, Lanfranco AR, Ma KC. Utility and safety of airway stenting in distal airways stenosis after lung transplant. J Bronchology Interv Pulmonol. 2020;27:274-279. A retrospective series reviewing the utility of lobar stenting in distal airway stenosis.
Guinde J, Bismuth J, Laroumagne S, et al. Bifurcated silicone stents for the management of anastomotic complications in lung transplanted patients: Ten years’ experience. Respiration. 2022;101:675–82.
Guibert N, Didier A, Moreno B, et al. Treatment of post-transplant complex airway stenosis with a three-dimensional, computer-assisted customized airway stent. Am J Respir Crit Care Med. 2017;195:e31–3.
Annangi S, Rahman T, Nandavaram S, Gaurav K, Baz M, Maskey A. Direct 3-dimensional printing: A novel technology for customized airway stents. J Heart Lung Transplant. 2020;39:1164–5.
Meyer A, Warszawski-Baumann A, Baumann R, et al. HDR brachytherapy: An option for preventing nonmalignant obstruction in patients after lung transplantation. Strahlenther Onkol. 2012;188:1085–90.
Tendulkar RD, Fleming PA, Reddy CA, Gildea TR, Machuzak M, Mehta AC. High-dose-rate endobronchial brachytherapy for recurrent airway obstruction from hyperplastic granulation tissue. Int J Radiat Oncol Biol Phys. 2008;70:701–6.
Faccioli E, Dell’Amore A, Ferrigno P, et al. Surgical management of post-transplant bronchial stenoses: A single-center experience. Surg Today. 2022;52:449–57.
Murgu S, Colt H. Tracheobronchomalacia and excessive dynamic airway collapse. Clin Chest Med. 2013;34:527–55.
Krishnam MS, Suh RD, Tomasian A, et al. Postoperative complications of lung transplantation: Radiologic findings along a time continuum. Radiographics. 2007;27:957–74.
Novick RJ, Ahmad D, Menkis AH, et al. The importance of acquired diffuse bronchomalacia in heart-lung transplant recipients with obliterative bronchiolitis. J Thorac Cardiovasc Surg. 1991;101:643–8.
Singh J, Sese D, Lehr CJ, Pichurko B, McCurry K, Mehta AC. Effect of bilateral lung transplantation on excessive dynamic airway collapse. Clin Transplant. 2019;33: e13578.
Aslam A, De Luis Cardenas J, Morrison RJ, et al. Tracheobronchomalacia and excessive dynamic airway collapse: Current concepts and future directions. Radiographics. 2022;42:1012–27.
Murgu SD, Colt HG. Complications of silicone stent insertion in patients with expiratory central airway collapse. Ann Thorac Surg. 2007;84:1870–7.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
The authors declare no competing interests.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Ong, P., Velez, M. Airway Complications of Lung Transplantation. Curr Pulmonol Rep 12, 218–227 (2023). https://doi.org/10.1007/s13665-023-00327-8
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13665-023-00327-8