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Cryobiopsy in Interstitial Lung Disease: Is It Prime Time?

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Abstract

Purpose of Review

Transbronchial cryobiopsy (TBCB) may be used as an alternative to surgical lung biopsy (SLB) for the histopathologic evaluation of interstitial lung disease (ILD) at experienced centers. The purpose of this review is to discuss recent guidelines and evidence for the use of TBCB in the diagnosis of ILD including technique, review of efficacy, safety, and future perspectives.

Recent Findings

TBCB delivers reasonable diagnostic efficacy and offers meaningful contributions to multidisciplinary discussion (MDD) by increasing diagnostic confidence, providing prognostic information, and influencing management. TBCB has a favorable safety profile compared to SLB when performed at centers of expertise; however, a steep learning curve is well documented.

Summary

TBCB is an acceptable alternative to SLB in the evaluation of ILD when performed with appropriate expertise. Further research on diagnostic efficacy, safety in high-risk populations, use of imaging guidance techniques, and necessary procedural training is required.

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Acknowledgements

Image courtesy: Image 1. Pathology slides: Frank Schneider MD. Image 2C. Cyobiopsy gross sample picture: Keriann VanNostrand MD. Image 3. ERBE cryoprobes and unit.

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  1. Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Emory University School of Medicine, Atlanta, GA, USA

    Stephanie F. Hampton, Matthew Schimmel & Abesh Niroula

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Hampton, S.F., Schimmel, M. & Niroula, A. Cryobiopsy in Interstitial Lung Disease: Is It Prime Time?. Curr Pulmonol Rep 12, 125–133 (2023). https://doi.org/10.1007/s13665-023-00310-3

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