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Sleep, Obstructive Sleep Apnea, and Chronic Alveolar Hypoventilation in Cystic Fibrosis: Role of Noninvasive Ventilation During Sleep

  • Sleeping and Breathing (A Abreu, Section Editor)
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Abstract

Purpose of Review

We describe sleep disturbances in patients with cystic fibrosis emphasizing treatment of abnormal breathing during sleep with noninvasive ventilation.

Recent Findings

Advances in treatment have transformed cystic fibrosis from a pediatric disorder to an adult condition. The increase in cystic fibrosis life expectancy renders these patients at high risk for nocturnal and diurnal respiratory failure. Hypoventilation during sleep precedes diurnal hypoventilation in cystic fibrosis. In advanced cases, noninvasive ventilation improves awake ABGs, respiratory muscle strength, dyspnea, subjective sleep quality, and level of daily activities and attenuates sleep hypoventilation.

Summary

Noninvasive ventilation can ameliorate symptoms and improve gas exchange, particularly in cystic fibrosis with advanced lung dysfunction. There is insufficient literature describing the effect of noninvasive ventilation on survival in cystic fibrosis.

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Author information

Authors and Affiliations

  1. Sleep Disorders Center, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA

    Pamela Barletta, Alexandre R. Abreu & Alejandro D. Chediak

  2. Division of Pulmonary, Critical Care and Sleep Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA

    Pamela Barletta, Maria Tupayachi Ortiz, Alexandre R. Abreu & Alejandro D. Chediak

  3. Department of Medicine, University of Kansas Medical School, Kansas City, USA

    Matthias Salathe

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  1. Pamela Barletta
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  3. Alexandre R. Abreu
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Contributions

All authors met the four criteria for authorship established by the International Committee of Medical Journal Editors: Pamela Barletta, Alejandro Chediak, Alexandre Abreu, Maria Tupayachi Ortiz, and Matthias Salathe were responsible for the conception, design, and drafting the work, revising the work and reviewing the manuscript. All authors provided final approval of the version to be published and agreed to be accountable for all aspects of the work in ensuring including the accuracy and/or integrity of the work.

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Correspondence to Alejandro D. Chediak.

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Barletta, P., Ortiz, M.T., Abreu, A.R. et al. Sleep, Obstructive Sleep Apnea, and Chronic Alveolar Hypoventilation in Cystic Fibrosis: Role of Noninvasive Ventilation During Sleep. Curr Pulmonol Rep 9, 110–117 (2020). https://doi.org/10.1007/s13665-020-00252-0

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