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NSCLC: State of the Art Diagnosis, Treatment, and Outcomes

Abstract

Purpose of Review

Lung cancer is the major cause of cancer mortality in the USA. In this review, we aim to provide a general update on the current status of non-small cell lung cancer (NSCLC) management.

Recent Findings

Novel approaches in the diagnosis and treatment of non-small cell lung cancer have been made recently and this was revolutionary in the way lung cancer management has changed even-though the improvement in overall survival remains modest. Furthermore, lung cancer screening using low-dose computed tomography scan has shown benefit in high-risk populations.

Summary

The diagnosis of lung cancer has evolved over the last couple of years with the new endoscopic modalities. Targeted therapies and immunotherapies, including tyrosine kinase inhibitors and checkpoint inhibitors, constitutes the current progress made in the treatment of lung cancer, and have helped improve survival in the metastatic setting. Many trials are ongoing in investigating other biomarkers.

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Fig. 1

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Correspondence to Gerard Chaaya.

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Gerard Chaaya, Ramsy Abdelghani, Fayez Kheir, Takefumi Komiya, and Nancy Vander Velde declare no conflict of interest.

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Chaaya, G., Abdelghani, R., Kheir, F. et al. NSCLC: State of the Art Diagnosis, Treatment, and Outcomes. Curr Pulmonol Rep 7, 29–41 (2018). https://doi.org/10.1007/s13665-018-0198-z

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Keywords

  • Non-small cell lung cancer
  • Diagnosis
  • Endobronchial ultrasound
  • Molecular studies
  • Targeted therapy
  • Immunotherapy