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Sleep-Related Breathing Disorders and Cancer

  • Sleeping and Breathing ( T Lee-Chiong, Section Editor)
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Abstract

Purpose of Review

Obstructive sleep apnea (OSA) has been investigated the most within the spectrum of sleep-related breathing disorders in cancer. The purpose of this review is to describe the biological pathways and review the epidemiological studies regarding OSA and cancer, and to additionally explore the spectrum of sleep-related breathing disorders in cancer.

Recent Findings

Murine models have elucidated intermittent hypoxia and sleep fragmentation as oncogenic, and large epidemiologic studies have identified increased cancer incidence among those with OSA and hypoxemia. Central sleep apnea (CSA) may develop in those using opioids for pain control. Sleep-related hypoventilation should be considered in those with underlying pulmonary dysfunction, vocal cord abnormalities, and neuromuscular weakness.

Summary

Cancer patients are at risk of developing sleep-related breathing disorders in the form of OSA, CSA, or sleep-related hypoventilation. The impact of sleep-related breathing disorders on cancer may have ramifications for the prevention and treatment of cancer.

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Acknowledgements

Thanks to Dr. George Eapen for commissioning and reviewing this paper.

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Authors and Affiliations

  1. Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1462, Houston, TX, 77030-4009, USA

    Diwakar D. Balachandran, Lara Bashoura & Saadia A. Faiz

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  1. Diwakar D. Balachandran
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  2. Lara Bashoura
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  3. Saadia A. Faiz
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Correspondence to Diwakar D. Balachandran.

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L.B., S.F., and D.B. declare no conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This research is supported in part by the National Institutes of Health through MD Anderson’s Cancer Center Support Grant (CA016672).

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This article is part of the Topical Collection on Sleeping and Breathing

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Balachandran, D.D., Bashoura, L. & Faiz, S.A. Sleep-Related Breathing Disorders and Cancer. Curr Pulmonol Rep 6, 90–101 (2017). https://doi.org/10.1007/s13665-017-0182-z

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