Manuka honey: an emerging natural food with medicinal use

Abstract

The health value of honey is universally acknowledged from time immemorial. Manuka (Leptospermum scoparium) is a tree, indigenous to New Zealand and South East Australia, and from the myrtle family, Myrtaceae. The honey produced from its flowers is a uni-floral honey largely produced in New Zealand. It is becoming increasingly popular as a functional food, seen in the aisles of health stores as its displays superior nutritional and phytochemistry profile over other varieties of honey. Examining existing research databases revealed its biological properties ranging from anti-oxidant, anti-inflammatory, anti-bacterial, anti-viral, anti-biotic and wound healing to immune-stimulatory properties. Methylglyoxal is the unique compound in the honey responsible for some of its potent anti-microbial properties. Further, propolis another component of honey contains chiefly flavonoids (i.e. galangin, pinocembrin), phenolic acids and their esters that may also contribute to its immuno-stimulant properties. Recent findings of the biological roles have been discussed with emphasis on the underlying mechanisms. The hurdles associated in its development as a functional food and also nutraceutical with future scopes have also been mentioned. Relevant data published in MEDLINE, Cochrane library, and EMBASE in the past decade have been gathered to formulate this review.

References

  1. [1]

    Schneider, M.; Coyle, S.; Warnock, M.; Gow, I.; Fyfe, L. Phytother. Res.2012, doi: 10.1002/ptr.4844.

    Google Scholar 

  2. [2]

    Tan, H. T.; Rahman, R. A.; Gan, S. H.; Halim, A. S.; Hassan, S. A.; Sulaiman, S. A.; Kirnpal-Kaur, B. S. BMC Complement. Altern. Med.2009, 9, 34.

    PubMed Central  Article  PubMed  Google Scholar 

  3. [3]

    Shelock, O.; Dolan, A.; Athman, R.; Power, A.; Gethin, G.; Cowman, S.; Humpreys, H. BMC Complement. Altern. Med.2010, 10, 47.

    Article  Google Scholar 

  4. [4]

    Anthimidou, E.; Mossialos, D. J. Med. Food2013, 16, 42–47.

    Article  PubMed  Google Scholar 

  5. [5]

    Bone, K. Phytother. Press, Warwick, QLD, Australia 2007.

    Google Scholar 

  6. [6]

    Oddo, L.P.; Heard, T.A.; Rodriguez-Malaver, A.; Perez, R. A.; Fernandez-Muino, M.; Sancho, M. T.; Sesta, G.; Lusco, L.; Vit, P. J. Med. Food2008, 11, 789–794.

    Article  CAS  PubMed  Google Scholar 

  7. [7]

    Mao, W.; Schuler, M. A.; Berenbaum, M. R. Proc. Natl. Acad. Sci. USA2013, 110, 8842–8846.

    PubMed Central  Article  CAS  PubMed  Google Scholar 

  8. [8]

    Zha, W. J.; Qian Y.; Shen, Y.; Du, Q.; Chen, F. F.; Wu, Z. Z.; Li, X.; Huang, M. Evid. Based Complement. Alternat. Med.2013, 767689.

    Google Scholar 

  9. [9]

    Wang, S. B.; Pang, S. B; Gao, M.; Fang, L. H; Du, G. H. Chin. J. Nat. Med.2013, 11, 207–213.

    Article  CAS  PubMed  Google Scholar 

  10. [10]

    Daher, S.; Gulacar, F. O. J. Agric. Food Chem.2010, 56, 5775–5780.

    Article  Google Scholar 

  11. [11]

    Kato, Y.; Umeda, N.; Maeda, A.; Matsumoto, D.; Kitamoto, N.; Kikuzaki, H. J. Agric. Food Chem.2012, 60, 3418–3423.

    Article  CAS  PubMed  Google Scholar 

  12. [12]

    Jo, Y. H.; Kim, S. B.; Ahn, J. H.; Liu Q.; Hwang, B. Y.; Lee, M. K. Nat. Prod. Commun.2013, 8, 481–483.

    CAS  PubMed  Google Scholar 

  13. [13]

    Curir, P.; Dolci, M.; Dolci P.; Lanzotti, V.; De Cooman, L. Phytochem. Anal.2003, 14, 8–12.

    Article  CAS  PubMed  Google Scholar 

  14. [14]

    Oelschlaegel, S.; Gruner, M.; Wang, P. N.; Boettcher, A.; Koelling-Speer, I.; Speer, K. J. Agric. Food Chem.2012, 60, 7229–7237.

    Article  CAS  PubMed  Google Scholar 

  15. [15]

    Kim J. H.; Chang, P. K.; Chan, K. L.; Faria, N. C.; Mahoney, N.; Kim, Y. K.; Martins Mde, L.; Campbell, B. C. Int. J. Mol. Sci.2012, 11, 13867–13880.

    Article  Google Scholar 

  16. [16]

    Atrott, J.; Haberlau, S.; Henle, T. Carbohydr. Res.2012, 361, 7–11.

    Article  CAS  PubMed  Google Scholar 

  17. [17]

    Inoue, K.; Murayama, S.; Seshimo, F.; Takeba, K.; Yoshimura, Y.; Nakazawa, H. J. Sci. Food Agric.2005, 85, 872–878.

    Article  CAS  Google Scholar 

  18. [18]

    Leong, A. G.; Herst, P. M.; Harper, J. L. Innate Immun.2011, 18, 459–466.

    Article  PubMed  Google Scholar 

  19. [19]

    Keenan, J. I.; Salm, N.; Wallace, A. J.; Hampton, M. B. Phytother. Res.2012, 26, 1620–1625.

    Article  CAS  PubMed  Google Scholar 

  20. [20]

    Chepulis, L. M.; Francis, E. J. Complement. Integr. Med.2012, 9, 1.

    Article  CAS  Google Scholar 

  21. [21]

    Alzahrani, H. A.; Alsabehi, R.; Boukraa, L.; Abdellah, F.; Bellik, Y.; Bakhotmah, B. A. Molecules2012, 17, 10540–10549.

    Article  CAS  PubMed  Google Scholar 

  22. [22]

    Wolbeling, F.; Munder, A.; Kerber-Momot, T.; Neumann, D.; Henning, C.; Hansen, G.; Tummler, B.; Baumann, U. Immunobiology2011, 216, 901–908.

    Article  PubMed  Google Scholar 

  23. [23]

    English, H. K.; Pack, A. R.; Molan, P. C. J. Int. Acad. Periodont.2004, 6, 63–67.

    Google Scholar 

  24. [24]

    Nayak, P. A.; Nayak, U. A.; Mythili, R. Contemp. Clin. Dent.2010, 1, 214–217.

    PubMed Central  CAS  PubMed  Google Scholar 

  25. [25]

    Badet, C.; Quero, F. Anaerobe2011, 17, 19–22.

    Article  CAS  PubMed  Google Scholar 

  26. [26]

    Stojicic, S.; Amorim, H.; Shen, Y.; Haapasalo, M. Int. Endod. J.2013, 47, 649–659.

    Article  Google Scholar 

  27. [27]

    Cooper, R. A.; Molan, P. C.; Krishnamoorthy, L.; Harding, K. G. Eur. J. Clin. Microbiol. Infect. Dis.2001, 20, 758–759.

    Article  CAS  PubMed  Google Scholar 

  28. [28]

    Henriques, A. F.; Jenkins, R. E.; Burton, N. F.; Cooper, R. A. Eur. J. Clin. Microbiol. Infect. Dis.2010, 29, 45–50.

    Article  CAS  PubMed  Google Scholar 

  29. [29]

    Kilty, S. J.; Duval, M.; Chan, F. T.; Ferris, W.; Slinger, R. Int. Forum Allergy Rhinol.2011, 1, 348–350.

    Article  PubMed  Google Scholar 

  30. [30]

    Roberts, A. E.; Maddocks, S. E.; Cooper, R. A. Microbiology2012, 158, 3005–3013.

    Article  CAS  PubMed  Google Scholar 

  31. [31]

    Alzahrani, H. A.; Boukraa, L.; Bellik, Y.; Abdellah, F.; Bakhotmah, B. A.; Kolayli, S.; Sahin, H. Glob. J. Health Sci.2012, 4, 191–196.

    PubMed  Google Scholar 

  32. [32]

    Packer, J. M.; Irish, J.; Herbert, B. R.; Hill, C.; Padula, M.; Blair, S. E.; Carter, D. A.; Harry, E. J. Int. J. Antimicrob. Agents2012, 40, 43–50.

    Article  CAS  PubMed  Google Scholar 

  33. [33]

    Maddocks, S. E.; Lopez, M. S.; Rowlands, R. S.; Cooper, R. A. Microbiology2012, 158, 781–790.

    Article  CAS  PubMed  Google Scholar 

  34. [34]

    Lin, S. M.; Molan, P. C.; Cursons, R. T. Eur. J. Clin. Microbiol. Infect. Dis.2009, 28, 339–344.

    Article  CAS  PubMed  Google Scholar 

  35. [35]

    Lin, S. M.; Molan, P. C.; Cursons, R. T. Eur. J. Clin. Microbiol. Infect. Dis.2011, 30, 569–574.

    Article  CAS  PubMed  Google Scholar 

  36. [36]

    Lu, J.; Carter, D. A.; Turnbull, L.; Rosendale, D.; Hedderley, D.; Stephens, J.; Gannabathula, S.; Steinhorn, G.; Schlothauer, R. C.; Whitchurch, C. B.; Harry, E. J. PLoS One2013, 8, e55898.

    PubMed Central  Article  CAS  PubMed  Google Scholar 

  37. [37]

    Bang, L. M.; Buntting, C.; Molan, P. J. Altern. Complement. Med.2003, 9, 267–273.

    Article  PubMed  Google Scholar 

  38. [38]

    Majtan, J.; Bohova, J.; Horniackova, M.; Klaudiny, J.; Majtan, V. Phytother. Res.2013, doi: 10.1002/ptr.4957.

    Google Scholar 

  39. [39]

    Jenkins, R. E.; Cooper, R. J. Antimicrob. Chemother.2012, 67, 1405–1407.

    Article  CAS  PubMed  Google Scholar 

  40. [40]

    Jenkins, R.; Cooper, R. PLoS One2012, 7, e45600.

    PubMed Central  Article  CAS  PubMed  Google Scholar 

  41. [41]

    Muller, P.; Alber, D. G.; Turnbull, L.; Schlothauer, R. C.; Carter, D. A.; Whitchurch, C. B.; Harry, E. J. PLoS One2013, 8, e57679.

    PubMed Central  Article  CAS  PubMed  Google Scholar 

  42. [42]

    Elkins, J. G.; Hassett, D. J.; Stewart, P. S.; Schweizer, H. P.; McDermott, T. R. Appl. Environ. Microbiol.1999, 65, 4594–4600.

    PubMed Central  CAS  PubMed  Google Scholar 

  43. [43]

    Shahzad, A.; Cohrs, R. J. Transl. Biomed.2012, 3, 2.

    PubMed Central  PubMed  Google Scholar 

  44. [44]

    Pesce, M.; Patruno, A.; Speranza, L.; Reale, M. Eur. Cytokine Netw.2013, 24, 1–10.

    Google Scholar 

  45. [45]

    Gethin, G. T.; Cowman, S.; Conroy, R. M. Int. Wound J.2008, 5, 185–194.

    Article  PubMed  Google Scholar 

  46. [46]

    Armstrong, D. G. Evid. Based Med.2009, 14, 148.

    Article  PubMed  Google Scholar 

  47. [47]

    Rudzka-Nowak, A.; Luczywek, P.; Gajos, M. J.; Piechota, M. Med. Sci. Monit.2010, 16, 138–142.

    Google Scholar 

  48. [48]

    Hampton, S.; Coulborn, A.; Tadej, M.; Bree-Aslan, C. Br. J. Nurs.2011, 20, 38, 40–43.

    Google Scholar 

  49. [49]

    Bischofberger, A. S.; Dart, C. M.; Perkins, N. R.; Kelly, A.; Jeffcott, L.; Dart, A. J. Vet. Surg.2012, 42, 154–160.

    Article  PubMed  Google Scholar 

  50. [50]

    Trudgian, J.; Trotman, S. Br. J. Nurs.2011, 20, 10, 12, 14.

    Article  Google Scholar 

  51. [51]

    Thomas, M.; Hamdan, M.; Hailes, S.; Walker, M. J. Wound Care2011, 20, 528, 530–533.

    Google Scholar 

  52. [52]

    Ranzato, E.; Martinotti, S.; Burlando, B. Wound Repair. Regen.2012, 20, 778–785.

    Article  PubMed  Google Scholar 

  53. [53]

    Doerler, M.; Reich-Schupke, S.; Altmeyer, P.; Stucker, M. J. Dtsch. Dermatol. Ges.2012, 10, 624–632.

    PubMed  Google Scholar 

  54. [54]

    Kim, J.; Kim, O. S.; Kim, C. S.; Sohn, E.; Jo, K.; Kim, J. S. Exp. Mol. Med.2012, 44, 167–175.

    PubMed Central  Article  PubMed  Google Scholar 

  55. [55]

    Kamaratos, A. V.; Tzirogiannis, K. N.; Iraklianou, S. A.; Panoutsopoulos, G. I.; Kanellos, I. E.; Melidonis, A. I. Int. Wound J.2012, PMID 22985336.

    Google Scholar 

  56. [56]

    Sell, S. A.; Wolfe, P. S.; Spence, A. J.; Rodriguez, I. A.; McCool, J. M.; Petrella, R. L.; GArg, K.; Ericksen, J. J.; Bowlin, G. L. Int. J. Biomater.2012, doi: 10.1155/2012/313781

    Google Scholar 

  57. [57]

    Tonks, A. J.; Cooper, R. A.; Jones, K. P.; Blair, S.; Parton, J.; Tonks, A. Cytokine2003, 21, 242–247.

    Article  CAS  PubMed  Google Scholar 

  58. [58]

    Hsiang, C. Y.; Hseu, Y. C.; Chang, Y. C.; Kuamr, K. J.; Ho, T. Y.; Yang, H. L. Food Chem.2013, 136, 426–434.

    Article  CAS  PubMed  Google Scholar 

  59. [59]

    Chepulis, L. M.; Francis, E. J. Complement. Integr. Med.2012, 9 26.

    Google Scholar 

  60. [60]

    Lu, J.; Randell, E.; Han, Y.; Adeli, K.; Krahn J.; Meng Q. H. Clin. Biochem.2011, 44, 307–311.

    Article  CAS  PubMed  Google Scholar 

  61. [61]

    Tonks, A. J.; Dudley, E.; Porter, N. G.; Parton, J.; Brazier, J.; Smith, E. L.; Tonks, A. J. Leukoc. Biol.2007, 82, 1147–1155.

    Article  CAS  PubMed  Google Scholar 

  62. [62]

    Fernandez-Cabezudo, M. J.; El-Kharrag, R.; Torab, F.; Bashir, G.; George, J. A.; El-Taji, H.; Al-Ramadi, B. K. PLoS One2013, 8, e55993.

    PubMed Central  Article  CAS  PubMed  Google Scholar 

  63. [63]

    Radhika, M.; Ghoshal, N.; Chatterjee, A. Ind. J. Exp. Biol.2012, 50, 491–496.

    Google Scholar 

  64. [64]

    Bhandary, S.; Chaki, S.; Mukherjee, S.; Das, S.; Mukherjee, S.; Chaudhri, K.; Dastidar, S. G. Ind. J. Exp. Biol.2012; 50, 491–496.

    CAS  Google Scholar 

  65. [65]

    Majtan, J. Evid. Based Complement. Alternat. Med.2011, 2011, ID 295494.

  66. [66]

    Rabbani, N.; Godfrey, L.; Xue, M.; Shaheen, F.; Geoffrion, M.; Milne, R.; Thornalley, P. J. Diabetes2011, 60, 1973–1980.

    PubMed Central  Article  CAS  PubMed  Google Scholar 

  67. [67]

    Li, Y. C.; Tsai, S. H.; Chen, S. M.; Chang, Y. M.; Huang, T. C.; Huang, Y. P.; Chang, C. T.; Lee, J. A. Biochem. Biophys. Res. Commun.2012, 423, 832–837.

    Article  CAS  PubMed  Google Scholar 

  68. [68]

    Aron, M.; Victoria Akinpelu, O.; Dorion, D.; Daniel, S. Head Neck Surg.2012, 41, 21–30.

    Google Scholar 

  69. [69]

    Maletta, A. B.; Were, L. M. J. Food Sci.2012, 77, 135–141.

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Seema Patel.

Additional information

This article is published with open access at Springerlink.com

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Patel, S., Cichello, S. Manuka honey: an emerging natural food with medicinal use. Nat. Prod. Bioprospect. 3, 121–128 (2013). https://doi.org/10.1007/s13659-013-0018-7

Download citation

Keywords

  • manuka honey
  • methylglyoxal
  • antimicrobial
  • wound therapy
  • anti-ulcer agent