Abstract
Two new tirucallane triterpenoids, 2 α-ethoxy-2,3-secotirucalla-2,29-epoxy-7-ene-23-oxo-3-oic acid (1) and (23E)-2 α-hydroxytirucalla-7,23,25-triene-3-one (2), along with the known 2,3-secotirucalla-2,3;2,29-diepoxy-7-ene-3,23-dione (3), were isolated from the leaves and twigs of Aphanamixis grandifolia. Their structures were elucidated by extensive NMR and MS data, and compound 3 was further confirmed by X-ray crystal diffraction analysis. Antimicrobial activities and insecticidal activities of these three compounds were also evaluated. Compound 1 showed good antimicrobial activity against Staphylococcus aureus with the MIC value of 1.56 µg/mL, while compounds 1 and 2 showed insecticidal activity at 100 ppm, with the corrected mortality 79.1% and 60.6%, respectively.
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Wang, XY., Tang, GH., Yuan, CM. et al. Two new tirucallane triterpenoids from Aphanamixis grandifolia. Nat. Prod. Bioprospect. 2, 222–226 (2012). https://doi.org/10.1007/s13659-012-0059-3
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DOI: https://doi.org/10.1007/s13659-012-0059-3