Abstract
Three new azaphilone compounds, isochromophilones X–XII (1–3), together with two known ones sclerotioramine (4) and isochromophilone VI (5) were isolated from the cultures of an endophytic fungus Diaporthe sp. The structures were elucidated by extensive HRESIMS and NMR spectroscopic analyses. All compounds were tested for their cytotoxicities against five human cancer cell lines by MTT method, among which compound 1 showed moderate inhibitory effects on these cell lines. This was the first report of azaphilones isolated from Diaporthe sp.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Udagawa, S. I. Chem. Pharm. Bull.1963, 11, 366–367.
Arai, N.; Shiomi, K.; Tomoda, H.; Tabata, N.; Yang, D. J.; Masuma, R.; Kawakubo, T.; Omura, S. J. Antibiot.1995, 48, 696–702.
Osmanova, N.; Schultze, W.; Ayoub, N. Phytochem. Rev.2010, 9, 315–342.
Ge, H. M.; Zhang, W. Y.; Ding, G.; Saparpakorn, P.; Song, Y. C.; Hannongbua, S.; Tan, R. X. Chem. Commun.2008, 45, 5978–5980.
Laakso, J. A.; Raulli, R.; McElhaney-Feser, G. E.; Actor, P.; Underiner, T. L.; Hotovec, B. J.; Mocek, U.; Cihlar, R. L.; Broedel, S. E. Jr. J. Nat. Prod.2003, 66, 1041–1046.
Anke, H.; Kemmer, T.; Höfle, G. J. Antibiot.1981, 34, 923–928.
Quang, D. N.; Hashimoto, T.; Tanaka, M; Stadler, M.; Asakawa, Y. Phytochemistry2004, 65, 469–473.
Yasukawa, K.; Itabashi, T.; Kawai, K. I.; Takido, M. J. Nat. Med.2008, 62, 384–386.
Zhang, Y. L.; Zhang, J.; Jiang, N.; Lu, Y. H.; Wang, L.; Xu, S. H.; Wang, W.; Zhang, G. F.; Xu, Q.; Ge, H. M.; Ma, J.; Song, Y. C.; Tan, R. X. J. Am. Chem. Soc.2011, 133, 5931–5940.
Guo, Z. K.; Yan, T.; Guo, Y.; Song, Y. C.; Jiao, R. H.; Tan, R. X.; Ge, H. M. J. Nat. Prod.2012, 75, 15–21.
Wang, X.; Sena Filho, J. G.; Hoover, A. R.; King, J. B.; Ellis, T. K.; Powell, D. R.; Cichewicz, R. H. J. Nat. Prod.2010, 73, 942–948.
Michael, A. P.; Grace, E. J.; Kotiw, M.; Barrow, R. A. Aust. J. Chem.2003, 56, 13–15.
Lee, S. Y.; Clark, R. C.; Boger D. L. J. Am. Chem. Soc.2007, 129, 9860–9861.
Clark, R. C.; Lee, S. Y.; Boger D. L. J. Am. Chem. Soc.2008, 130, 12355–12369.
Matsuzaki, K.; Tanaka, H.; Ōmura, S. J. Antibiot.1995, 48, 708–713.
Kanokmedhakul, S.; Kanokmedhakul, K.; Nasomjai, P.; Louangsysouphanh, S.; Soytong, K.; Isobe, M.; Kongsaeree, P.; Prabpai, S.; Suksamrarn, A. J. Nat. Prod.2006, 69, 891–895.
Hajjaj, H.; Klaebe, A.; Loret, M. O.; Goma, G.; Blanc, P. J.; Francois, J. Appl. Environ. Microbiol.1999, 65, 311–314.
Author information
Authors and Affiliations
Corresponding authors
Additional information
This article is published with open access at Springerlink.com
Electronic supplementary material
Rights and permissions
Open Access This article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Zang, LY., Wei, W., Wang, T. et al. Isochromophilones from an endophytic fungus Diaporthe sp.. Nat. Prod. Bioprospect. 2, 117–120 (2012). https://doi.org/10.1007/s13659-012-0023-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13659-012-0023-2