Abstract
Two polyene macrolide antibiotics: antifungalmycin (1) and fungichromin (2) were isolated from the culture mycelia of Streptomyces padanus 702 via bioactivity-guided fractionation using various chromatographic procedures. Their structures were elucidated on the basis of spectral analysis, and 1 is a new polyene macrolide. Compounds 1 and 2 showed significant inhibition against Gibberella zeae with EC50 values of 26.71 and 2.21 µg/mL, Fusicoccum sp. (plantain head blight) with EC50 values of 23.4 and 3.17 µg/mL, Mucor ssp. 8894 with EC50 values of 28.80 and 2.11 µg/mL, Ustilaginoidea virens with EC50 values of 26.72 and 0.21 µg/mL, respectively. This shows that the microbial secondary metabolites 1 and 2 have the potential to be developed as agricultural fungicides for use against G. zeae, Fusicoccum sp., Mucor ssp. 8894, and U. virens.
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Yu, F.; Li, Z.; Zeng, H. Chin. J. Trop. Agric.2005, 25, 60–65.
Dewaard, M. A.; Georgopoulos, S. G.; Hollomon, D. W.; Ishii, H.; Leroux, P.; Ragsdale, N. N.; Schwinn, F. J. Annu. Rev. Phytopathol.1993, 31, 403–421.
Takeuchi, S.; Hirayama, K.; Ueda, K.; Sakai, H.; Yonehara, H. J. Antibiot.1958, 11, 1–5.
Umezawa, H.; Okami, Y.; Hashimot. T; Suhara, Y.; Hamada, M.; Takeuchi, T. J. Antibiot.1965, 18, 101–103.
Koontz, J. L.; Marcy, J. E. J. Agric. Food Chem.2003, 51(24), 7106–7110.
Iwasa, T.; Higashid. E; Yamamoto, H.; Shibata, M. J. Antibiot.1971, 24, 107–110.
Noguchi, H.; Harrison, P. H.; Arai, K.; Nakashima, T. T.; Trimble, L. A.; Vederas, J. C. J. Am. Chem. Soc.1988, 110, 2938–2945.
Yu, Z. G.; Zhao, L. X.; Jiang, C. L.; Duan, Y. W.; Wong, L.; Carver, K. C.; Schuler, L. A.; Shen, B. J. Antibiot.2011, 64, 159–162.
Tchize Ndejouong Ble, S.; Sattler, I.; Maier, A.; Kelter, G.; Menzel, K.; Fiebig, H.; Hertweck, C. J. Antibiot.2010, 63, 359–363.
Seo, Y.; Cho, K. W.; Lee, H. S.; Yoon, T. M.; Shin, J. H. J. Microbiol. Biotechnol.2000, 10, 176–180.
Zhou, Y.; Zhang, Z.; Tu, X.; Tu, G. Jiangxi Nongye Daxue Xuebao2009, 31, 1127–1133.
Pandey R. C.; Guenther E. C.; Aszalos A. A. J. Antibiot.1982, 35, 988–996.
Aqueveque, P.; Anke, T.; Anke, H.; Sterner, O.; Becerra, J.; Silva, M. J. Antibiot.2005, 58, 61–64.
Kettering, M.; Valdivia, C.; Sterner, O.; Anke, H.; Thines, E. J. Antibiot.2005, 58, 390–396.
Anke, T.; Werle, A.; Kappe, R. B.; Sterner, O. J. Antibiot.2004, 57, 496–501.
Ellis, D. J. Antimicrob. Chemother.2002, 49, 7–10.
Cespedes, C. L.; Avila, J. G.; Martinez, A.; Serrato, B.; Calderon-Mugica, J. C.; Salgado-Garciglia, R. J. Agric. Food Chem.2006, 54, 3521–3527.
Vinale, F.; Flematti, G.; Sivasithamparam, K.; Lorito, M.; Marra, R.; Skelton, B. W.; Ghisalberti, E. L. J. Nat. Prod.2009, 72, 2032–2035.
Konishi, K.; Kuragano, T. Nippon Noyaku Gakkaishi1990, 15, 13–22.
Konishi, K.; Kuragano, T. Nippon Noyaku Gakkaishi1989, 14, 351–357.
Liermann, J. C.; Kolshorn, H.; Opatz, T.; Thines, E.; Anke, H. J. Nat. Prod.2009, 72, 1905–1907.
Kim, B. S.; Moon, S. S.; Hwang, B. K. J. Agric. Food Chem.1999, 47, 3372–3380.
Hwang, B. K.; Lee, J. Y.; Kim, B. S.; Moon, S. S. J. Agric. Food Chem.1996, 44, 3653–3657.
Lee, J. Y.; Yun, B. S.; Hwang, B. K. J. Agric. Food Chem.2004, 52, 776–780.
Ma, Y. F.; Liu, L.; Feng, H. M.; Shi, J. J.; Ni, J. P. Xiandai Nongyao2009, 8, 21–22, 26.
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Wang, YF., Wei, SJ., Zhang, ZP. et al. Antifungalmycin, an antifungal macrolide from Streptomyces padanus 702. Nat. Prod. Bioprospect. 2, 41–45 (2012). https://doi.org/10.1007/s13659-011-0037-1
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DOI: https://doi.org/10.1007/s13659-011-0037-1