Abstract
Four new limonoids, dysohainanins A–D (1–4), and two new triterpenoids, dysohainanins E and F (5 and 6), together with seven known ones were isolated from the twigs and leaves of Dysoxylum hainanense Merr. The structures of the new compounds were determined by a variety of spectroscopic methods. The cytotoxic activities of these compounds were evaluated, and the known compound ent-19-nor-4,16,18-trihydroxy-8(14)-pomaren-15-one (13) showed in vitro cytotoxicity against HL-60, A-549, MCF-7, and SW480 cells, with IC50 values of 24.3, 28.1, 30.7, and 22.5 µM, respectively. Compounds 2 and 3 were tested their insecticidal activities using brine shrimp and both of them were inactive.
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Duh, C. Y.; Wang, S. K.; Chen, I. S. J. Nat. Prod.2000, 63, 1546–547.
Chen, J. L.; Kernan, M. R.; Jolad, S. D.; Stoddart, C. A.; Bogan, M.; Cooper, R. J. Nat. Prod.2007, 70, 312–315.
Aladesanmi, A. J.; Ilesanmi, O. R. J. Nat. Prod.1987, 50, 1041–1044.
Kashiwada, Y.; Fujioka, T.; Chang, J. J.; Chen, I. S.; Mihashi, K. M.; Lee, K. H. J. Org. Chem.1992, 57, 6946–6953.
Versha, P.; Manoj, G.; Bajaj, B. K. Indian Perfumer2003, 47, 183–187.
Luo, X. D.; Wu, S. H.; Wu, D. G.; Ma, Y. B.; Qi, S. H. Tetrahedron2002, 58, 7797–7804.
He, X. F.; Wang, X. N.; Yin, S.; Dong, L.; Yue, J. M. Eur. J. Org. Chem.2009, 2009, 4818–4824.
Luo, X. D.; Wu, S. H.; Ma, Y. B.; Wu, D. G. Phytochemstry2000, 54, 801–805.
Luo, X. D.; Wu, S. H.; Ma, Y. B.; Wu, D. G. Phytochemstry2001, 57, 131–134.
Luo, X. D.; Wu, S. H.; Ma, Y. B.; Wu, D. G. Acta Bot. Yunnan.2001, 23, 368–372.
Luo, X. D.; Wu, S. H.; Yang, X. S.; Teng, R. W.; Ma, Y. B.; Wu, D. G.; Hao, X. J.; Lu, Y.; Liu, X. Y.; Zheng, Q. T. Heterocycles2000, 53, 2225–2232.
He, X. F.; Wang, X. N.; Gan, L. S.; Yin, S.; Dong, L.; Yue, J. M. Org. Lett.2008, 10, 4327–4330.
He, X. F.; Wang, X. N.; Yin, S.; Dong, L.; Yue, J. M. Bioorg. Med. Chem. Lett.2011, 21, 125–129.
Zhang, X. Y.; Zhang, R. T.; Cai, X. H.; Liu, Y. P.; Luo, X. D. Z. Naturforsch. B2010, 65, 1161–1163.
Pudhom, K.; Sommit, D.; Nuclear, P.; Ngamrojanavanich, N.; Petson, A. J. Nat. Prod.2009, 72, 2188–2191.
Singh, Y.; Aalbersberg, W. Phytochemstry1992, 31, 4033–4035.
Wang, X. N.; Fan, C. Q.; Yin, S.; Lin, L. P.; Ding, J.; Yue, J. M. Helv. Chim. Acta2008, 91, 510–519.
Monks, A.; Scudiero, D.; Skehan, P.; Shoemaker, R.; Paull, K.; Vistica, D.; Hose, C.; Langley, J.; Cronise, P.; Vaigro, W. J. Natl. Cancer Inst.1991, 83, 757–766.
Wang, Z. Q.; Zhou, H.; Han, J.; He, Y. Q.; Lu, L. P. Agrochemicals2011, 50, 261–262, 275.
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Liu, WX., Tang, GH., He, HP. et al. Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense. Nat. Prod. Bioprospect. 2, 29–34 (2012). https://doi.org/10.1007/s13659-011-0030-8
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DOI: https://doi.org/10.1007/s13659-011-0030-8