Abstract
Crataeva tapia bark lectin was evaluated for its antitumor activity against sarcoma 180 in Swiss albino mice. The anti-inflammatory and analgesic properties were investigated in models of inflammation and nociception. The anti-inflammatory assay was induced by carrageenan induced peritonitis and the analgesic activity was induced by acetic acid-induced writhing response. The lectin presents low toxicity with a LD50 of 2,500 mg/kg body weight and significant antitumor activity causing inhibition of tumor growth. The lectin also promoted significant reduction (35.4%) in the number of neutrophil migration induced by carrageenan. Concerning its analgesic property, the lectin inhibits abdominal contractions induced by acetic acid. The current results revealed a lectin with significant antitumoral, anti-inflammatory and antinociceptive activities. Further investigations to unveil the exact mechanisms are needed.
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Araújo, R.M.S., Vaz, A.F.M., Aguiar, J.S. et al. Lectin from Crataeva tapia bark exerts antitumor, anti-inflammtory and analgesic activities. Nat. Prod. Bioprospect. 1, 97–100 (2011). https://doi.org/10.1007/s13659-011-0014-8
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DOI: https://doi.org/10.1007/s13659-011-0014-8