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La misurazione dello iodio: una breve rassegna

The iodine measurement: a brief review

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La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine

Riassunto

Dati affidabili sulla concentrazione iodica nelle urine sono indispensabili per programmare con efficienza gli interventi da intraprendere a livello nazionale per correggere eventuali iodiopenie. La maggior parte dei Laboratori utilizza il metodo analitico individuato anni fa da Sandell-Kolthoff, che è una reazione di riduzione catalizzata dallo iodio utilizzando diverse sostanze ossidanti nella prima fase di digestione di eventuali interferenti. Oggi esistono altri metodi analitici che possono essere semi-quantitativi, contemplare l’impiego di micropiastre, metodi colorimetrici messi in automatico, ma ormai la tecnica più avanzata è la spettrometria di massa a plasma indotto. Con questo lavoro si vuole fare una panoramica delle metodiche in uso anche per valutarne pregi e difetti.

Summary

Good quality data on iodine concentrations in urine and salt samples are indispensable for the efficient management of national salt iodisation programmes and for evaluating iodine interventions. Most of the analytical methods for urinary iodine concentration are based on the manual spectrophotometric measurement of Sandell-Kolthoff reduction reaction catalysed by iodine using different oxidising reagents in the initial digestion step. Other analytical methods include semi-quantitative methods, a microplate method, automated methods; and the technologically advanced methods include the inductively coupled plasma mass-spectrometer method. With this work you want to do an overview of the methods used for assessing its strengths and weaknesses.

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Bibliografia

  1. Zimmermann MB, Jooste PL, Pandav CS (2008) Iodine deficiency disorders. Lancet 372:1251–1262

    Article  CAS  PubMed  Google Scholar 

  2. Ajjani RA, Watson PF, Findlay C et al. (1998) The sodium iodide symporter gene and its regulations by cytokines found in autoimmunity. J Endocrinol 158:351–358

    Article  Google Scholar 

  3. Bidart JM, Mian C, Lazar V et al. (2000) Expression of pendrin and the pendred syndrome gene in human thyroid tissues. J Clin Endocrinol Metab 85:2028–2033

    CAS  PubMed  Google Scholar 

  4. Andreoli M (2001) Fisiopatologia e clinica delle tireopatie e diagnostica molecolare. Il Pensiero Scientifico Editore, Roma

    Google Scholar 

  5. Andreoli M (2001) Ricambio dello iodio, biosintesi e secrezione degli ormoni tiroidei. In: La tiroide, fisiopatologia e diagnostica molecolare. Il Pensiero Scientifico Editore, Roma, pp 43–55

    Google Scholar 

  6. Trimboli P, Marchioni E (2009) Le malattie da deficit dell’apporto iodico e le metodiche di determinazione della ioduria. RIMeL/IJLaM 5:184–188

    CAS  Google Scholar 

  7. Pastorelli AA, Stacchini P, Olivieri A (2015) Daily iodine intake and the impact of salt reduction on iodine prophylaxis in the Italian population. Eur J Clin Nutr 69:211–215

    Article  CAS  PubMed  Google Scholar 

  8. Nazeri P, Mirmiran P, Shiva N et al. (2015) Iodine nutrition status in lactating mothers residing in countries with mandatory and voluntary iodine fortification programs: an updated systematic review. Thyroid 25:611–620

    Article  CAS  PubMed  Google Scholar 

  9. Braverman LE (1994) Iodine and the thyroid: 33 years of study. Thyroid 4:351–356

    Article  CAS  PubMed  Google Scholar 

  10. Laurberg P, Jorgensen T, Perrild H et al. (2006) The Danish investigation on iodine intake and thyroid disease. DanThyr: status and perspectives. Eur J Endocrinol 155:219–228

    Article  CAS  PubMed  Google Scholar 

  11. Sandell EB, Kolthoff IM (1937) Micro determination of iodine by a catalytic method. Microchimica Acta 1:9–25

    Article  CAS  Google Scholar 

  12. Dunn JT, Myers HE, Dunn AD (1998) Simple methods for assessing urinary iodine, including preliminary description of a new rapid technique (Fast B). Exp Clin Endocrinol Diabetes 106(Suppl):S10–S12

    Article  CAS  PubMed  Google Scholar 

  13. Dunn JT, Crutchfield HE, Gutekunst R et al. (1993) Two simple methods measuring iodine in urine. Thyroid 2:119–123

    Article  Google Scholar 

  14. Zava TT, Kapur S, Zava DT (2013) Iodine and creatinine testing in urine dried on filter paper. Anal Chim Acta 764:64–69

    Article  CAS  PubMed  Google Scholar 

  15. Giovanella L, Imperiali M (2009) Ioduria: indicatore di carenza iodica nel paziente o nella popolazione? RIMeL/IJLaM 5:189–190

    Google Scholar 

  16. Macours P, Aubry JC, Hauquier B et al. (2008) Determination of urinary iodine by inductively coupled plasma mass spectrometry. J Trace Elem Med Biol 22:162–165

    Article  CAS  PubMed  Google Scholar 

  17. Jooste PL, Strydom E (2010) Methods for determination of iodine in urine and salt. Best Pract Res Clin Endocrinol Metab 24:77–88

    Article  CAS  PubMed  Google Scholar 

  18. Rendl J, Seybold S, Börner W (1994) Urinary iodide determined by paired-ion reverse-phase HPLC with electrochemical detection. Clin Chem 40:908–913

    CAS  PubMed  Google Scholar 

  19. Haldimann M, Zimmerli B, Als C et al. (1998) Direct determination of urinary iodine by inductively coupled plasma mass spectrometry using isotope diluition with iodine 129. Clin Chem 44:817–824

    CAS  PubMed  Google Scholar 

  20. Momĉilovic B, Prejac J, Višnjevic V et al. (2014) Hair iodine for human iodine status assessment. Thyroid 24:1018–1026

    Article  PubMed  PubMed Central  Google Scholar 

  21. Zhang W, Mnatsakanov A, Hower R et al. (2005) Urinary iodine assays and ionophore based potentiometric iodide sensors. Front Biosci 10:88–93

    Article  CAS  PubMed  Google Scholar 

  22. Als C, Helbling A, Peter K et al. (2000) Urinary iodine concentration follows a circadian rhythm: a study with 3023 spot urine samples in adults and children. J Clin Endocrinol Metab 85:1367–1369

    CAS  PubMed  Google Scholar 

  23. Wuethrich C, Jaeggi-Groisman SE, Gerber H (2000) Comparison of two methods for the detection of urinary iodine used in epidemiological studies. Clin Chem Lab Med 10:1027–1031

    Google Scholar 

  24. Ji X, Liu P, Sun Z et al. (2016) Intra-individual variation in urinary iodine concentration: effect of statistical correction on population distribution using seasonal three-consecutive-day spot urine in children. BMJ Open 6:e010217

    Article  PubMed  PubMed Central  Google Scholar 

  25. König F, Andersson M, Hotz K et al. (2011) Ten repeat collection for urinary iodine from spot samples or 24 hours samples are needed to reliably estimate individual iodine status in women. J Nutr 141:2049–2054

    Article  PubMed  Google Scholar 

  26. Perrine CG, Cogswell ME, Swanson CA et al. (2014) Comparison of population iodine estimates from 24-hour urine and timed spot urine samples. Thyroid 24:748–757

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Li C, Peng S, Zhang X et al. (2016) The urine iodine to creatinine as an optimal index of iodine during pregnancy in an iodine adequate area in China. J Clin Endocrinol Metab 101:1290–1298

    Article  CAS  PubMed  Google Scholar 

  28. Soldin OP (2002) Controversies in urinary iodine determinations. Clin Biochem 35:575–579

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Andersen S, Karmisholt J, Pedersen KM et al. (2008) Realibility of studies of iodine intake and recommendations for number of samples in groups and in individuals. Br J Nutr 99:813–818

    CAS  PubMed  Google Scholar 

  30. Jooste PL, Strydom E (2010) Methods for determination of iodine in urine and salt. Best Pract Res Clin Endocrinol Metab 24:77–88

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Giulio Ozzola.

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Ozzola, G. La misurazione dello iodio: una breve rassegna. Riv Ital Med Lab 12, 216–220 (2016). https://doi.org/10.1007/s13631-016-0129-3

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  • DOI: https://doi.org/10.1007/s13631-016-0129-3

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