Riassunto
Viene presentato un documento relativo alla determinazione dell’albuminuria preparato all’interno del Gruppo di Studio Intersocietario Diabete Mellito SIBioC-SIMeL.
Le indicazioni contenute nel documento sono state elaborate a partire dai lavori del Gruppo di Studio IFCC-NKDEP sull’argomento e riflettono le evidenze disponibili al momento, ma sono orientate alla misura e all’interpretazione del dato nell’ambito della nefropatia diabetica.
Le raccomandazioni riguardano la parte preanalitica, analitica e interpretativa della misura; le indicazioni sulle quali esiste unanime consenso sono riassunte in Tabelle esplicative.
Summary
Recommendations on the urine albumin measurement for diabetic nephropathy diagnosis and monitoring
We present here a paper on urine albumin measurement elaborated within the Working Group on Diabetes Mellitus (SIBioC-SIMeL). The suggestions included are based on the papers prepared by the IFCC-NKDEP Working Group on urine albumin measurement and are based on the best available evidence; they are, however, directed at the management of the test for the diagnosis and monitoring of diabetic nephropathy. The recommendations relate to the pre-analytical, analytical and interpretative phases. The suggestions based on an established expert consensus are summarised in a table.
Bibliografia
American Diabetes Association (2010) Standards of medical care in diabetes. Diabetes Care 33:S11–S61
Standards Italiani per la cura del Diabete Mellito 2009–2010 http:www.siditalia.it/images/Documenti/2010_linee_guida.pdf. Data di consultazione: Agosto 2010
Brantsma AH, Bakker SJ, Hillege HL et al (2008) Cardiovascular and renal outcome in subjects with K/DOQI stage 1–3 chronic kidney disease: the importance of urinary albumin excretion. Nephrol Dial Transplant 23:3851–3858
American Diabetes Association (2004) Position Statement. Nephropathy in diabetes. Diabetes Care 27:S79–S83
Graziani MS, LoCascio C, Caldini AL et al (2007) Indagine conoscitiva sulla determinazione quantitativa della albumina nelle urine nei laboratori italiani. Biochimica Clinica 31:290–296
Panteghini M (2010) 2009 Annual Report of the IFCC Scientific Division (SD). Biochimica Clinica 34:153–158
Miller GW, Bruns DE, Hortin GL et al (2009) Current issues in measurement and reporting of urinary albumin excretion. Clin Chem 35:24–38
Miller WG, Bruns DE (2009) Laboratory issues in measuring and reporting urine albumin. Nephrol Dial Tranplant 24:717–718
Osika TM, Comper WD (2004) Characterisation of immunochemically nonreactive urinary albumin. Clin Chem 50:2286–2291
Sviridov D, Drake SK, Hortin GL (2008) Reactivity of urinary albumin (microalbumin) assays with fragmented or modified albumin. Clin Chem 54:61–68
Sacks DB, Bruns DE, Goldstein DE et al (2002) Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem 48:436–472
Mosca A, Paleari R, Ceriotti F et al (2003) Biological variability of albumin excretion rate and albumin to creatinine ratio in hypertensive type 2 diabetic patients. Clin Chem Lab Med 41:1229–1233
Graziani MS, Gambaro G, Mantovani L et al (2009) Diagnostic accuracy of a reagent strip for assessing urinary albumin excretion in the general population. Nephrol Dial Tranplant 24:1490–1494
Vassalotti JA, Stevens LA, Levey AS (2007) Testing for chronic kideny disease: a position statement from the National Kidney foundation. Am J Kidney Dis 50:169–180
Ruggenenti P, Remuzzi G (2006) Time to abandon microalbuminuria? Kidney Intern 70:1214–1222
Zamora CR, Cubeddu LX (2009) Microalbuminuria: do we need a new threshold? J Human Hypertens 23:146–154
Author information
Authors and Affiliations
Corresponding author
Additional information
per il Gruppo di Studio Intersocietario Diabete Mellito SIBioC-SIMeL
Rights and permissions
About this article
Cite this article
Graziani, M.S., Caldini, A.L. Indicazioni per la misura dell’albumina nelle urine per l’accertamento e il monitoraggio della nefropatia diabetica. Riv Ital Med Lab 7, 20–24 (2011). https://doi.org/10.1007/s13631-011-0004-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13631-011-0004-1