Abstract
We report on the systematic review and meta-analysis concerning the efficacy of R. officinalis in treating diabetes mellitus (DM) in animals. This study followed the PRISMA guideline and the protocol was registered in PROSPERO (CRD42021250556). The research was duplicated in the PubMed, Scopus, ScienceDirect, Web of Science, and Virtual Health Library (VHL) databases until December 31st, 2022. No restrictions have been set for language publication. Twenty-three (23) experimental studies of type-1 diabetes mellitus (T1DM) met the eligibility criteria and were included in the qualitative analysis, whereas eighteen (18) underwent a meta-analysis. The R. officinalis derivatives significantly decreased fasting plasma glucose (MD: −120.84 [95% CI; −157.09, −84.59]); increased insulin release (MD; +3.73 [95% CI; +3.17, +4.29]); dwindled blood urea nitrogen (MD: −24.84 [95% CI; −34.78, −14.90]) and creatinine (MD: −0.40 [95% CI; −0.74, −0.06]) levels; and ameliorated liver function or repaired liver damage by decreasing ALT (MD: −36.42; [95% CI; −55.69, −17.14]) and AST (MD: −24.05 [95% CI; −37.84, −10.27]) enzyme levels compared to vehicle control group. Moreover, R. officinalis derivatives improved the lipid profile of diabetic animals by reducing LDL-c levels (MD: −11.74 [95% CI; −21.27, −2.21]). R. officinalis is a nutraceutical that may help in the management of T1DM and its complications. However, some gaps need to be taken into account for this evidence. Greater attention is needed for an analytical standardization of Rosemary extracts besides the demand for high-quality clinical studies dealing with the efficacy of this phytomedicine.
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Abbreviations
- Alb:
-
Albumin
- ALP:
-
Alkaline phosphatase
- ALT:
-
Alanine aminotransferase
- AST:
-
Aspartate aminotransferase
- AUR:
-
Uric acid
- BUN:
-
Blood urea nitrogen
- CAMARADES:
-
Collaborative Approach to Meta Analysis and Review of Animal Experimental Studies
- CI:
-
Confidence interval
- CRE:
-
Creatinine
- D.O.I:
-
Digital Object Identifier System
- DeCS:
-
Health Sciences Descriptors
- DM:
-
Diabetes mellitus
- FPG:
-
Fasting plasma glucose
- HbA1c:
-
Serum glycated hemoglobin
- HDL-c:
-
High density lipoprotein cholesterol
- LDL-c:
-
Low density lipoprotein cholesterol
- MD:
-
Mean difference
- MeSH:
-
Medical Subject Headings
- OS:
-
Oxidative stress
- PRISMA:
-
Preferred Reporting Items for Systematic Reviews and Meta-Analyses
- RevMan:
-
Review Manager software
- ROs:
-
Reactive oxygen species
- SD:
-
Standard deviation
- SIL:
-
Serum insulin level
- SYRCLE:
-
Systematic Review Center for Laboratory animal Experimentation
- T1DM:
-
Type-1 diabetes mellitus
- T2DM:
-
Type-2 diabetes mellitus
- TC:
-
Total cholesterol
- Tg:
-
Total triglycerides
- VHL:
-
Virtual Health Library
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Acknowledgements
We appreciate Dr. Zbys Fedorowicz (Veritas Health Sciences Consultancy) and Gesner Francisco Xavier Junior (librarian of the Medical School – Federal University of Minas Gerais) for their valuable support with the review protocol.
Funding
Virgínia Moura Oliveira received a scientific initiation grant (PIBIC) from the Universidade Federal de São João del- Rei and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (UFSJ/FAPEMIG; grant number 21092). Kitete Tunda Bunnel received a Master’s grant from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES; grant number 88887.824838/2023-0). This study was also funded in part by the CAPES - Financial Code 001.
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ROC: Conceptualization, Funding acquisition, Project administration, Supervision, Writing—review & editing; NRB and CPD: Methodology, Formal analysis, Software, Writing—review & editing; VMO: Data curation, Formal analysis, Investigation, Writing—original draft; LRS: Investigation, Validation; KTB and AOB: Writing—review & editing.
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Virginia Moura Oliveira has no conflict of interest. Letícia Rafaela Silveira has no conflict of interest. Kitete Tunda Bunnel has no conflict of interest. Caroline Pereira Domingueti has no conflict of interest. André Oliveira Baldoni has no conflict of interest. Nayara Ragi Baldoni has no conflict of interest. Renê Oliveira do Couto has no conflict of interest.
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Oliveira, V.M., Silveira, L.R., Bunnel, K.T. et al. Rosemary (Rosmarinus officinalis L.) improves biochemical outcomes in diabetes mellitus: a systematic review and meta-analysis of animal studies. ADV TRADIT MED (ADTM) (2024). https://doi.org/10.1007/s13596-024-00742-5
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DOI: https://doi.org/10.1007/s13596-024-00742-5