Abstract
An ethnobotanical survey was conducted in Katsina state, Northern Nigeria to document medicinal plants commonly used by lactating mothers to boost breast milk production. Two hundred and forty (240) respondents made up of (120) nursing mothers, (60) herbalists and (60) traditional birth attendants were interviewed. Ethnobotanical data was obtained using the structured questionnaire method. Standard procedures were followed to analyse the phyto-chemical, proximate, mineral concentrations and chemical composition of the ethanolic extract of the most cited plants. Forty (40) plant species belonging to 38 genera distributed among 24 families are used as galactagogues in Katsina state, Nigeria. All the plant samples contained alkaloids, cardiac glycosides, flavonoids, saponins, tannins and terpenoids. Anthraquinones were found to be absent in Andropogon gayanus, Moringa oleifera and Pennisetum glaucum while phytosterol was absent in Pennisetum glaucum and Vernonia amygdalina. They were also found to contain nutrient compositions in varying amounts. Crotalaria retusa had the highest moisture (12.80%), crude lipid (13.50%) and crude fibre (21.76%) content. Momordica balsamina has the highest ash (13.76%) content. Pennisetum glaucum had the highest carbohydrate content (76.19%) and energy content (364.95%). Mineral analysis revealed that Andropogon gayanus, Momordica balsamina and Vernonia amygdalina showed equal phosphorus (0.3 ppm) contents. Crotalaria retusa showed the highest chromium (2.59 ppm) and copper (1.31 ppm) content. GC/MS analysis revealed that Momordica balsamina contained 99 phytoconstituents. With only 9,12-Octadecadienoic acid (Z,Z)- identified as the only phytoconstituents showing phytoestrogen activity. The indigenous knowledge about lactating mothers in Katsina state, Nigeria used medicinal plants to boost breast milk production is documented.
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References
Aleandri V, Bertazzoni G, Romanzi D, Vetrano G, Durazzi F, Mazzanti G, Vitalone A (2014) The use of herbal products during breastfeeding: a study from a public Italian hospital. J Food Process Technol 5(8):1. https://doi.org/10.4172/2157-7110.1000354
Anstalt SV (2013) Food and agriculture organization of United Nations. Food energy-methods of analysis and conversion factors. Food and Nutrition, Rome
AOAC (2005) International, 2005. Official methods of analysis of the association of official analytical chemists. 17th edition. Arlington, Virginia
Arredondo M, Nunez MT (2005) Iron and copper metabolism. Mol Aspects Med 26(4–5):313–327. https://doi.org/10.1016/j.mam.2005.07.010
Ayoola GA, Coker HAB, Adesegun SA, Adepoju-Bello AA, Obaweya K, Ezennia EC, Atangbayila TO (2008) Phytochemical screening and antioxidant activities of some selected medicinal plants used for malarial therapy in Southwestern Nigeria. Trop J Pharm Res 7(3):1019–1024. https://doi.org/10.4314/tjpr.v7i3.14686
Balikci A, Balibey H (2012) Postpartum depression due to use of metaclopramide: a case report. Anatol J Clin Investig 6(1):258–260
Beard JL (2001) Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr 131(2):568S-580S
Bergman C, Gray-Scott D, Chen JJ, Meacham S (2009) What is next for the dietary reference intakes for bone metabolism related nutrients beyond calcium: phosphorus, magnesium, vitamin D, and fluoride? Crit Rev Food Sci Nutr 49(2):136–144. https://doi.org/10.1080/10408390701764468
Chantry C, Wiedeman J, Buehring G, Peerson J, Hayfron K, Kaluoch O, Lonnerdal B et al (2011) Effect of flash - heat treatment on antimicrobial activity of breast milk. Breastfeed Med 6(3):111–116. https://doi.org/10.1089/bfm.2010.0078
Chuang CH, Chang PJ, Hsieh WS, Tsai YJ, Lin SJ, Chen PC (2009) Chinese herbal medicine use in Taiwan during pregnancy and the postpartum period: a population-based cohort study. Int J Nurs Stud 46(6):787–795. https://doi.org/10.1016/j.ijnurstu.2008.12.015
Curran ME (1998) Potassium ion channels and human disease: phenotypes to drug targets? Curr Opin Biotechnol 9(6):565–572. https://doi.org/10.1016/S0958-1669(98)80133-X
Edem DO, Amugo CI, Eka OU (1990) Chemical composition of yam beans (Sphenostylis stenocarpa). Trop Sci 30(1):59–63
Edeoga HO, Omosun G, Uche LC (2006) Chemical composition of Hyptis suaveoleus and Ocimum gratissimum hybrids from Nigeria. Afr J Biotechnol 5(10)
Elemo O, Oreagba I, Akinwunmi A, Elemo G, Nicholas-Okpara V (2016) Lactation failure and potential of traditional herbs as galactagogues. Int J Healthc 4(1):427–434
Evans WC (2009) Trease Evan’s pharmacognosy E-book. Elsevier Health Sciences.
Fakhfakh MA, Fournet A, Prina E, Mouscadet JF, Franck X, Hocquemiller R, Figadere B (2003) Synthesis and biological evaluation of substituted quinolines: potential treatment of protozoal and retroviral co-infections. Bioorg Med Chem 11(23):5013–5023. https://doi.org/10.1016/j.bmc.2003.09.007
Gbadamosi IT, Okolosi O (2013) Botanical galactagogues: nutritional values and therapeutic potentials. J Appl Biosci 61:4460–4469. https://doi.org/10.4314/jab.v61i0.85594
Geraci A, Vincenza P, Rosario S (2018) Ethnobotanical uses of wild taxa as galactagogues in Sicily (Italy). Acta Soc Bot Pol 87(2):35–80. https://doi.org/10.5586/asbp.3580
Habicht JP, DaVanzo J, Butz WP, Meyers L (1985) The contraceptive role of breastfeeding. Popul Stud 39(2):213–232. https://doi.org/10.1080/0032472031000141456
Harper ME, Willis JS, Patrick J (1997) Sodium and chloride in nutrition. Handbook of Nutritionally Essential Mineral Elements 8217, (93–116).
Ishida H, Suzuno H, Sugiyama N, Innami S, Todokoro T, Maekawa A (2000) Nutritional evaluation of chemical component of leaves, stalks and stems of sweet potatoes (Ipomea batatas poir). Food Chem 68(3):357–367
Jackson P (2010) Complementary and alternative methods of increasing breast milk supply for lactating mothers of infants in the NICU. Neonatal Netw 29(4):225–230. https://doi.org/10.1891/0730-0832.29.4.225
James PB, Kaikai AI, Bah AJ, Steel A, Wardle J (2019) Herbal medicine use during breastfeeding: a cross-sectional study among mothers visiting public health facilities in the Western area of Sierra Leone. BMC Complement Altern Med 19(1):1–11. https://doi.org/10.1186/s12906-0192479-7
Kankara SS, Ibrahim MH, Mustapha M, Go R (2015) Ethnobotanical survey of medicinal plants used for traditional maternal healthcare in Katsina State. Nigeria s Afr J Bot 97:165–175. https://doi.org/10.1016/j.sajb.2015.01.007
Kent JC, Prime DK, Garbin CP (2012) Principles for maintaining or increasing breast milk production. J Obstet Gynecol Neonatal Nurs 41(1):114–121. https://doi.org/10.1111/j.1552-6909.2011.01313.x
Krone A, Eric JW, John TEC (2001) Cadmium in zinc - containing mineral supplements. Int J Food Sci Nutr 52(4):379–382. https://doi.org/10.1080/09637480120057602
Lloyd E (2011) The role of proteins in humans: how proteins help maintain life. Online (2013–02–11) updated, 5(24), 2011
Lönnerdal B, Keen CL, Hurley LS (1981) Iron, copper, zinc and manganese in milk. Annu Rev Nutr 1(1):149–174. https://doi.org/10.1146/annurev.nu.01.070181.001053
Lukaski HC, Siders WA, Penland JG (2007) Chromium picolinate supplementation in women: effects on body weight, composition, and iron status. Nutrition 23(3):187–195. https://doi.org/10.1016/j.nut.2006.12.001
Manikandan E, Prithiviraj B, Kavitha G, Magudapathy P, Rajamannan B (2011) 2 MeV-PIXE technique for coastal material analysis. Int J PIXE 21:75–86. https://doi.org/10.1142/S012908351100221
Modapa S, Tusi Z, Sridhar D, Kumar A, Siddiqi MI, Srivastava K, Batra S, (2009) Search for new pharmacophores for antimalarial activity. Part I: Synthesis and antimalarial activity of new 2-methyl-6-ureido-4-quinolinamides. Bioorg Med Chem 17(1):203–221. https://doi.org/10.1016/j.bmc.2008.11.021
Mohrbacher N, Stock J (1997) The breastfeeding answer book. 3rd Edition (revised). Schaumburg: La Leche League International. 586.
Morris MJ, Na ES, Johnson AK (2008) Salt craving: the psychobiology of pathogenic sodium intake. Physiol Behav 94(5):709–721. https://doi.org/10.1016/j.physbeh.2008.04.008
Moser-Veillon PB (1990) Zinc: consumption patterns and dietary recommendations. J Am Diet Assoc 90(8):1089–1093. https://doi.org/10.1016/s0002-8223(21)01706-5
National Research Council (1989) Diet and health: implications for reducing chronic disease risk. National Academies Press
Oddy WH, Kendal GE, Blair E, De Klerk NH, Stanley FJ, Landau LI (2003) Breast feeding and cognitive development in childhood: a prospective birth cohort study. Paediatr Perinat Epidemiol 17(1):81–90. https://doi.org/10.1046/j.1365-3016.2003.00464.x
Okwu DE (2001) Evaluation of the chemical composition of indigenous spices and flavouring agents. Glob J Pure and Appl Sci 7:455–459. https://doi.org/10.4314/gjpas.v7i3.16293
Onyeike EN, Olungwe T, Uwakwe AA (1995) Effect of heat treatment and defatting on the proximate composition of some Nigerian local soup thickeners. Food Chem 53(1):173–175. https://doi.org/10.1016/0308-8146(95)90784-5
Parkman HP, Mishra A, Jacobs M, Pathikonda M, Sachdeva P, Gaughan J, Krinetskiy E (2012) Clinical response and side effects of metaclopromide: associations with clinical, demographic and pharmacogenetics parameters. J Clin Gastroenterol 46(6):494–503. https://doi.org/10.1097/MCG.0b013e3182522624
Prithiviraj B, Manikandan E, Hariharan GN, Nair KGM (2011) Elemental accumulation patterns of the lichen species Physcia tribacoides nyl, Heterodermia dissecta and Bacidia beckhausii Körber from the Walayar Rf Region, Tamil Nadu, India. Int. J. PIXE 21:133–144. https://doi.org/10.1142/S0129083511002252
Rajesh YB (2018) Quinoline heterocycles: synthesis and bioactivity. Heterocycl Synth Biol Activit Intechopen 90(10):89–93. https://doi.org/10.5772/intechopen.81239
Rane Z, Anish Kumar P, Anusha B (2012) Phytochemical evaluation by GC-MS and in vitro anti oxidant activity of Punica granatum fruit rind extract. J Chem Pharm Res 4(6):2869–2873
Ravisankar R, Rajalakshmi A, Manikandan E (2006) Mineral characterization of soil samples in and around salt field area, Kelambakkam, Tamilnadu. India Acta Ciencia Indica Phys 32(3):341
Rosenbauer J, Herzig P, Giani G (2008) Early infant feeding and risk of type 1 diabetes mellitus: a nationwide population-based case-control study in pre-school children. Diabetes Metab Res Rev 24(3):211–222. https://doi.org/10.1002/dmrr.791
Rossiter S, Peron JM, Whitfield PJ, Jones K (2005) Synthesis and anthelmintic properties of arylquinolines with activity against drug resistant nematodes. Bioorg Med Chem Lett 15(21):4806–4808. https://doi.org/10.1016/j.bmcl.2005.07.044
Rudnicka AR, Owen CG, Strachan DP (2007) The effect of breastfeeding on cardiorespiratory risk factors in adult life. Paediatr 119(5):e1107–e1115. https://doi.org/10.1542/peds.2006-2149
Saboury AA, Atri MS, Sanati MH, Moosavi-Movahedi AA, Haghbeen K (2005) Effects of Calcium binding on the structure and stability of human growth hormone. Int J Biol Macromol 36(5):305–309. https://doi.org/10.1016/j.ijbiomac.2005.07.003
Saeed M, Khan H, Khan MA, Khan F, Khan SA, Muhammad N (2010) Quantification Of various metals and cytotoxic profile of aerial parts of Polygonatum verticillatum. Pak J Bot 42(6):3995–4002
Shapiro R, Heaney RP (2003) Co-dependence of calcium and phosphorus for growth and bone development under conditions of varying deficiency. Bone 32(5):532–540. https://doi.org/10.1016/S8756-3282(03)00060-7
Sibeko L, Dhansay MA, Charlton KE, Johns T, Gray-Donald K (2005) Beliefs, attitudes, and practices of breastfeeding mothers from a Periurban Community in South Africa. J Hum Lact 21(1):31–38. https://doi.org/10.1177/0890334404272388
Sim TF, Sherriff J, Hattingh HL, Parsons R, Tee LB (2013) The use of herbal medicines during breastfeeding: a population-based survey in Western Australia. BMC Complem Altern Med 13(1):1–10. https://doi.org/10.1186/1472-6882-13-317
Sofowora A (1993) Recent trends in research into African medicinal plants. J Ethnopharmacol 38(2–3):197–208. https://doi.org/10.1016/0378-8741(93)90017-Y
Sultana A, Rahman KU, Manjula S (2013) Clinical update and treatment of lactation insufficiency. Med J Islamic World Acad Sci 109(555):1–10
Tabares FP, Jaramillo JVB, Ruiz-Cortés ZT (2014) Pharmacological overview of galactogogues. Vet Med Int. https://doi.org/10.1155/2014/602894
Tardıo J, Pardo-de-Santayana M (2008) Cultural importance indices: a comparative analysis based on the useful wild plants of Southern Cantabria (Northern Spain). Econ Bot 62(1):24–39. https://doi.org/10.1007/s12231-0079004-5
Teres S, Barcelo-Coblijn G, Benet M, Alvarez R, Bressani R, Halver JE, Escriba PV (2008) Oleic acid content is responsible for the reduction in blood pressure induced by olive oil. Proc Natl Acad Sci 105(37):13811–13816. https://doi.org/10.1073/pnas.0807500105
Wang D, Du X, Zheng W (2008) Alteration of saliva and serum concentrations of manganese, copper, zinc, cadmium and lead among career welders. Toxicol Lett 176(1):40–47. https://doi.org/10.1016/j.toxlet.2007.10.003
Waziri AF, Anka SA, Bala AY, Shehu H (2013) A comparative analysis of nutrients and mineral elements content of Andropogon gayanus Kunth and Pennisetum pedicellatum Trin. Niger J Basic Appl Sci 21(1):60–64. https://doi.org/10.4314/njbas.v21i1.9
World Health Organization (2013) WHO traditional medicine strategy: 2014–2023. World Health Organisation.
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Ethical considerations were duly observed during data collection. All the respondents were briefed about the purposes of the work during data collection exercise. Ethical approval was obtained from department of Biology Umaru Musa Yar’adua University and the various ethical committees of the Local Government Authority involved in the study.
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Umar Lawal has no conflict of interest. Rukayat T. Mohammed has no conflict of interest. Sani M. Gidado has no conflict of interest. Sulaiman S. Kankara has no conflict of interest.
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Lawal, U., Mohammed, R.T., Gidado, S.M. et al. Ethnobotanical survey and nutritional composition of medicinal plants used for traditional galactagogue practice in Katsina state, Nigeria. ADV TRADIT MED (ADTM) 23, 899–914 (2023). https://doi.org/10.1007/s13596-022-00667-x
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DOI: https://doi.org/10.1007/s13596-022-00667-x