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Test comparison of seeds and skins extract of duku’s fruit (Lansium domesticum Corr.) against the amount of melanin pigment of skin mencit (Mus musculus) to prevent premature aging of the skin


Premature aging can occur due to excessive sun exposure which causes hyperpigmentation problems and causes brown or black patches on the skin. Duku (Lansium domesticum Corr.) contains flavonoids and vitamin C compounds that are effective in protecting the skin from sun exposure. This study aims to see the benefits of the extract of the seeds and peel of duku fruit (Lansium domesticum Corr.) On the amount of melanin pigment in the skin of mice (Mus musculus) as an anti-hyperpigmentation so that the dapjekal is a skin pen. Group P0 was a negative control, group P1 was exposed to sunlight for 20 days, group P2 mice were exposed to duku seed extract and then exposed to sunlight for 20 days, group P3 were exposed to duku peel and exposed to local sunlight for 20 days, P4 mice were exposed to sunlight 20 days, 21–30 days exposed to peel extract, and P5 mice exposed to sunlight 20 days, 21–30 days exposed to seed extract. The results showed that the P0 group had the amount of melanin pigment with an average of 7 grains, the P1 group: 68.4, P2 group: 26.6, P3 group: 29, P4 group: 7.2, and group P5 group: 12. The conclusion is that exposure to sunlight the amount of melanin pigment and offers the extract of the peel and seeds of duku fruit can reduce the amount of melanin pigment.

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The authors would like to appreciate the efforts ad contributions of the laboratory and technical staff during this research.



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All the five authors reviewed the paper and contributed in developing the content.

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Correspondence to Delima Engga Maretha.

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Study ethics this research was conducted according to ethical standards for the use of animals for scientific purposes. The research protocol obtained an ethical review from the Faculty of Public Health, University of Sriwijaya with registration number: 219/UN9.1.10/KKE/2020.

Conflict of interest

Delima Engga Maretha has no conflict of interest. Dini Afriansyah has no conflict of interest. Dewi Susilo Wati has no conflict of interest. Mashuri Masri has no conflict of interest. Ade Rizky Dwiyanti has no conflict of interest. Muhammad Ifham Hanif has no conflict of interest. Slamet Wardoyo has no conflict of interest.

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Maretha, D.E., Afriansyah, D., Wati, D.S. et al. Test comparison of seeds and skins extract of duku’s fruit (Lansium domesticum Corr.) against the amount of melanin pigment of skin mencit (Mus musculus) to prevent premature aging of the skin. ADV TRADIT MED (ADTM) (2022).

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  • Premature aging
  • Sunlight
  • Melanin pigment
  • Peel of duku’s extract
  • Seeds of duku’s extract