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Study of compounds, cytotoxicity and biological activities of essential oil of Satureja rechingeri Jamzad

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Abstract

Nowadays, the essential oil has received a special position for the treatment of diseases. Although Satureja rechingeri Jamzad is an endemic species of Iran, unfortunately few studies have been conducted on its biological properties. In this study, along with the analysis of the compounds of Satureja rechingeri essential oil, cytotoxic, antioxidant and antibacterial properties of the essential oil of this species were investigated. The compounds of prepared essential oil were analyzed by GC-FID and GC–MS using Clevenger. Disc diffusion and MTT methods were used to determine the antibacterial activity and cytotoxicity of the essential oil, respectively. The antioxidant activity of the essential oil was measured by two methods of reducing power assay and DPPH free radical scavenging. p-Cymene (46.5%) was the most identified compound in the essential oil. The essential oil showed higher inhibitory effect on seven bacterial strains relative to the standard antibiotics. The studied essential oil showed significant concentration-dependent inhibitory effect on four cancer cells of Vero, SW480, MCF7 and JET3 with 50% lethal effect of 15.6, 125, 15.6 and 250 µg/mL for each line, respectively. The highest adsorption (2.6 nM) was at 500 µg/mL for reducing power assay and 50% free radical inhibition at a concentration of 375 µg/mL for DPPH antioxidant assay. In general, the essential oil of Satureja rechingeri with high antioxidant, antibacterial and anticancer activity can be used as a cheap and affordable natural product in clinical and pharmaceutical fields.

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Authors and Affiliations

  1. Department of Biology, Payam Noor University, Bandar Abbas, Iran

    Mitra Arman, Mostafa Alinaghizadeh & Fatemeh Khosheghbal

  2. Department of Biotechnology, Faculty of Agriculture, Bu-Ali Sina University, Hamedan, Iran

    Kiana Pirian

  3. Animal Science Research Institute of Iran (ASRI), Agriculture Research, Education and Extension Organization (AREEO), Karaj, Iran

    Reza Nahavandi

  4. Persian Gulf and Oman Sea Ecology Research Center, Iranian Fisheries Sciences Research Institute, Agriculture Research Education and Extension Organization (AREEO), Bandar Abbas, Iran

    Saeid Tamadoni Jahromi

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  1. Mitra Arman
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  2. Kiana Pirian
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  3. Mostafa Alinaghizadeh
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  4. Fatemeh Khosheghbal
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  5. Reza Nahavandi
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  6. Saeid Tamadoni Jahromi
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Correspondence to Mitra Arman.

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This article does not contain any studies involving animals performed by any of the authors. This article does not contain any studies involving human participants performed by any of the authors.

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Mitra Arman has no conflict of interest. Kiana Pirian has no conflict of interest. Mostafa Alinaghizadeh has no conflict of interest. Fatemeh Khosheghbal has no conflict of interest. Reza Nahavandi has no conflict of interest. Saeid Tamadoni Jahromi has no conflict of interest.

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Arman, M., Pirian, K., Alinaghizadeh, M. et al. Study of compounds, cytotoxicity and biological activities of essential oil of Satureja rechingeri Jamzad. ADV TRADIT MED (ADTM) 22, 789–796 (2022). https://doi.org/10.1007/s13596-021-00596-1

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  • DOI: https://doi.org/10.1007/s13596-021-00596-1

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