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Clary sage essential oil and its biological activities


Salvia sclarea or “clary sage” is an aromatic plant that is used for various ailments especially among the women. The aim of this investigation was to evaluate the biological activities of clary sage oil with emphasis on its application in women health. The information of this study was extracted by key words of clary sage, S. sclarea, biological activities in references books and electronic resources. The results of investigation exhibited that the chemical composition of clary sage influenced from various ecological, geographical and environmental conditions, but linalool and linalyl acetate is known as main components of clary sage oil. Clary sage oil is used in aromatherapy for women during the menstrual cycle, childbirth and menopause. The modern clinical investigations confirmed the efficacy of clary sage oil as anti-stress, anti-depression and analgesic agents in primary dysmenorrhea. The anti-oxidant, antimicrobial, cytotoxic and anti-inflammatory effects of clary sage have been confirmed. Furthermore, clary sage oil is known as safe oil with no adverse effects. Designing the large clinical study to evaluate the oral efficacy of clary sage oil for women ailments is essential for future studies.

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The authors are thankful from TabibDaru Pharmaceutical Company, Kashan, Iran.

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Correspondence to Mohaddese Mahboubi.

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Mohaddese Mahboubi has no conflict of interest.

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Mahboubi, M. Clary sage essential oil and its biological activities. ADV TRADIT MED (ADTM) 20, 517–528 (2020).

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  • Clary sage
  • Salvia sclarea
  • Dysmenorrhea
  • Linalool
  • Linalyl acetate