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A randomized, double-blind study comparing multiple doses of Channa striatus supplementation for knee osteoarthritis

Abstract

Knee osteoarthritis (OA) is the leading cause of chronic disability at older age. Channa striatus (CS) is a freshwater fish that is traditionally valued for its medicinal properties in promoting wound healing and reducing post-operative pain. This study evaluate the efficacy of different doses of oral Channa striatus extract on primary knee osteoarthritis patients. A randomized, double-blind, placebo-controlled 3-arm trial was conducted comparing oral CS extract 1000 mg/day or 500 mg/day and placebo among knee OA patients for a 6-month intervention period. The main outcome measures were Western Ontario and McMaster University Osteoarthritis Index (WOMAC), analgesic scores and serum cartilage oligomeric matric protein (COMP). Laboratory-based blood tests were used as safety measures. A total of 120 patients were randomized, and 112 patients were included in the intention-to-treat analysis. Significant reductions in WOMAC stiffness and function scores were achieved at month 6 in CS 1000 mg/day and CS 500 mg/day compared to placebo groups (p < 0.05). No significant differences were found between the groups in terms of analgesic scores, serum COMP and biochemical parameters. No serious adverse events were reported in the study. In conclusion, both doses of CS showed similar efficacy and were more effective than the placebo in treating the symptoms of knee OA.

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Acknowledgements

This work was supported by the by Universiti Sains Malaysia Research University grant (grant number: 304/PPSP/661313181).The funder has no role in this study other than to provide the funding and all authors are independent from the funder. We would like to acknowledge the late Prof. Saringat Bai @ Baie and Assoc. Prof Zuraini Ahmad for their contributions to the study.

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Correspondence to Abdul Kadir Arifah.

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Ethical Statement

The research proposal was approved by the Human Research Ethics Committee, Universiti Sains Malaysia (Reference number: USM / JEPeM/ [272.2(10)]. This trial is registered in the Thai Clinical Trials Registry (TCTR). The registration number is TCTR20170513004. The registry website http://www.clinicaltrials.in.th/index.php.

Conflict of Interest

All authors declared no conflict of interest.

Informed consent

Written informed consent was obtained from all individual participants included in the study.

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Azidah, A., Arifah, A., Roslida, A.H. et al. A randomized, double-blind study comparing multiple doses of Channa striatus supplementation for knee osteoarthritis. Orient Pharm Exp Med 17, 345–354 (2017). https://doi.org/10.1007/s13596-017-0293-7

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Keywords

  • Osteoarthritis
  • Channa Striatus
  • Arthritis
  • Complementary
  • Biomarker