The methanol extract of Curcuma caesia (MECC) rhizome showed antidiabetic activity by lowering blood glucose in in vivo studies and controlled intestinal absorption of monosaccharides by inhibiting alpha amylase and alpha glucosidase. It also enhanced the glucose uptake in yeast cells, proving proper glucose utilization. The IC50 values of MECC were found to be 442.92 ± 10.05 μg/ml and 95.40 ± 9.74 μg/ml in alpha amylase and alpha glucosidase inhibition respectively. The extract has effective antioxidant activities, by successfully scavenging free radicals like superoxide and hydroxyl ions. The histopathological studies of pancreas showed gradual healing after treatment.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Tax calculation will be finalised during checkout.
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
Tax calculation will be finalised during checkout.
Abirami N, Natarajan B, Sagadevan E (2014) Phytochemical investigation and in vitro evaluation of hypoglycemic potential of Grewia hirsute. IJPBS 5:176–183
Ananthan R, Latha M, Pari RK, Baskar C, Bai V (2003) Effect of Gymnema montanum leaves on serum and tissue lipids in alloxan diabetic rats. Exp Diabetes Res 4:183–189
Biswas M, Kar B, Bhattacharya S, Kumar RBS, Ghosh AK, Haldar PK (2011) Antihyperglycemic activity and antioxidant role of Terminalia arjuna leaf in streptozotocin-induced diabetic rats. Pharm Biol 49:35–40
Chakraborty M, Karmakar I, Haldar S, Nepal A, Haldar PK (2015) Anticancer and antioxidant activity of methanol extract of Hippophae salicifolia in EAC induced swiss albino mice. IJPPS 7(8):180–184
Dhyania D, Maikhuria RK, Misra S, Rao KS (2010) Endorsing the declining indigenous ethnobotanical knowledge system of sea buckthron in central Himalaya. J Ethnopharmacol 127:329–334
Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70–77
Florence NT, Benoit MZ, Jonas K, Alexandra T, Desire DDP, Pierre K, Theophile D (2013) Antidiabetic and antioxidant effects of Annona muricata (Annonaceae) aqueous extract on streptozotocin-induced diabetic rats. J Ethnopharmacol 151:1–7
Habif S, Turgan N, Mutaf I (1997) Plasma catalase, glutathione peroxidase and selenium levels in adult diabetic patients. Turk J Med Sci 27:139–141
Haldar PK, Kar B, Bhattacharya S, Bala A, Kumar RBS (2010) Antidiabetic activity and modulation of antioxidant status by Sansevieria roxburghiana rhizome in streptozotocin-induced diabetic rats. Diabetol Croat 39(4):115–123
Hossan SJ, El-Sayed M, Aoshima H (2009) Antioxidative and anti α-amylase activities of four wild plants consumed by nomads in Egypt. Orient Pharm Exp Med 9(3):217–224
Kaneto H, Kawamori D, Matsuoka TA (2005) Oxidative stress and pancreatic beta cell dysfunction. Am J Ther 12:529–533
Karmakar I, Dolai N, Bala A, Haldar PK (2011) Anxiolytic and cns depressant activities of methanol extract of curcuma caesia rhizome. Pharmacologyonline 2:738–747
Kim JS, Hyun TK, Kim MJ (2011) The inhibitory effects of ethanol extracts from sorghum, foxtail millet and proso millet on α-glucosidase and α-amylase activitie. Food Chem 124:1647–1651
Kumar S, Singh R, Vasudeva N, Sharma S (2012) Acute and chronic animal models for the evaluation of anti-diabetic agents. Cardiovasc Diabetol 11(9):1–13
Kumar MR, Kavitha K, Haldar PK (2015) Hypoglycemic effect of Andrographis echioides on streptozotocin induced experimental rats. J Appl Pharmacol 7:60–68
Mishra SB, Rao CHV, Ojha SK, Vijayakumar M, Verma A (2010) An analytical review of plants for antidiabetic activity with their phytoconstituent & mechanism of action. IJPSR 1(1):29–46
Nain P, Saini V, Sharma S, Nain J (2012) Antidiabetic and antioxidant potential of Emblica officinalis Gaertn. Leaves extract in streptozotocin-inducedtype-2 diabetes mellitus (T2DM) rat. J Ethnopharmacol 142:65–71
OECD (2008) Guidelines for the testing of chemicals/section 4:health effects test no. 425:acute oral toxicity: up-and-down procedure. Paris: organisation for economic co-operation and development publishing.
Panda S, Chakraborty M, Majumder P, Mazumder S, Das S, Haldar PK (2016) Antidiabetic, antioxidant and anti-hyperlipidaemic activity of cucumis callosus in streptozotocin-induced diabetic rats. IJPPS 7(5):1978–1984
Saha P, Mazumder UK, Haldar PK, Sen SK, Naskar S (2011) Antihyperglycemic activity of Lagenaria siceraria. Aerial parts on streptozotocin induced diabetes in rats. Diabetol Croat 40(2):49–60
Soltani N, Keshavarz M, Dehpour AR (2007) Effect of oral magnesium sulfate administration on blood pressure and lipid profile in streptozotocin diabetic rat. Eur J Pharm Sci 560:201–205
Venukumar MR, Latha MS (2002) Antioxidant activity of Curculigo orchioides in carbon tetrachloride induced hepatopathy in rats. Indian J Clin Biochem 17:80–87
The authors are thankful to the Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Kolkata, India for providing necessary infrastructure and help. AICTE, India for providing necessary funds. They also want to thank Department of Science and Technology Inspire program, New Delhi, India,IF-140101.
All the procedures described were reviewed and approved by the University Animal Ethical Committee.
Conflict of Interest
The authors declare that they have no conflict of interest.
About this article
Cite this article
Majumder, P., Mazumder, S., Chakraborty, M. et al. Preclinical evaluation of Kali Haldi (Curcuma caesia): a promising herb to treat type-2 diabetes. Orient Pharm Exp Med 17, 161–169 (2017). https://doi.org/10.1007/s13596-017-0259-9
- Alpha amylase
- Alpha glucosidase
- Glucose uptake