Skip to main content
SpringerLink
Log in

Evaluation of diuretic activity of Syzygium cumini and its effect on prostaglandin system

  • Research Article
  • Published:
Oriental Pharmacy and Experimental Medicine Aims and scope Submit manuscript

Abstract

The objective of this study briefly focus on the evaluation of diuretic activity and its possible mechanism of action of methanolic extract of Syzygium cumini (MESCS) seeds. The MESCS doses (150 and 300 mg/kg) were orally administered to male Wistar albino rats. Urine volume, urinary excretion, diuretic action, diuretic activity, electrolyte levels in urine, natriuretic, saluretic, and carbonic anhydrase inhibitory activity, were measured in of saline loaded rats at 5 and 24th hour. Plasma creatinine and uric acid were also measured at 24th hour. The oral administration of MESCS increased the urine volume and electrolyte excretion at the 24th hour compared to 5th hour. To assess the involvement of the prostaglandin system in the mechanism of action, oral administration of methanolic extract of S. cumini (300 mg/kg) in association with Lornoxicam (3 mg/kg) reduced urinary and sodium, potassium, and chlorine excretion when compared to MESCS group. The results concluded that MESCS shown maximum diuretic activity at a dose of 300 mg/kg 24th hour and its mechanism involved prostaglandin system.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Abhishek KS, Vinod KV (2011) Syzygium cumini: an oveview. J Chem Pharm Res 3:108–11

  • Al-Ali M, Wahbi S, Twaij H, Al-Badr A (2003) Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethanopharmacol 85:257–260

    Article  Google Scholar 

  • Alvarez ME, Maria AOM, Villegas O, Saad JR (2003) Evaluation of diuretic activit of the constituents of Clematis monteridensis Spreng in Rats. Phytotheraphy Res 17:958–60

    Article  CAS  Google Scholar 

  • Amuthan A, Bharathi C, Bairy KL, Sudhakar, Prakash M (2012) Evaluation of diuretic activity of Amaranthus spinoosus Linn. aqueous extract in Wistar rats. J Ethanopharmacol 140:424–27

    Article  CAS  Google Scholar 

  • Benjumea D, Abdala S, Hernandez-Luis F, Perez-Paz P, Martin-Herrera D (2005) Diuretic activity of Artemisia thuscula, an endemic canary species. J Ethnopharmacol 100:205–209

  • Bernard N, Sacquet J, Benzoni D, Sassard J (2000) Cyclooxygenase 1 and 2 and thromboxane synthase in kidneys of lyon hypertensive rats. American J Hypertens 13:404–409

    Article  CAS  Google Scholar 

  • Demaria AN, Weir MR (2003) Loxibs beyond the gastro intestinal tract: renal and cardiovascular issues. J Pain Symptom Manag 25:41–49

    Article  Google Scholar 

  • Indian Pharmacopoeia (1996) Publications and information directorate (CSIR), New Delhi, India 2: 689

  • Jorge VG, Rolffy OA, Julio RL, Patricia CE, Rafael VM, Maximiliano IB et al (2010) Vasorelaxant and antihypertensive effects of methanolic extract from roots of Laelia anceps are mediated by Ca+2channel antagonism. Fitoterapia 81:350–357

    Article  Google Scholar 

  • Lipschitz WL, Hadidian Z, Kerpesar A (1943) Bioassay of diuretics. Pharmacol Ex Therap 79:97–110

    CAS  Google Scholar 

  • Mamun MM, Billah MM, Ashek MA, Ahasan MM, Hossai MJ, Sultana T (2003) Evaluation of diuretic activity of Ipomoea aquatic in mice model study. J Med Sci 9:395–400

    Google Scholar 

  • Modi DC, Patel JK, Shah BN, Nayak BS (2010) Pharmacognostic studies of the seed of Syzygium cumini Linn. Int J Pharmaceutical Sci 1:113–125

    Google Scholar 

  • Mukherjee PK, Pal M, Saha K, Saha BP (1996) Diuretic activity of extract of the rhizomes of Nelumbonucifera gaertn. Phytotherapy Res 10:424–25

    Article  Google Scholar 

  • Murugesan T, Manikandan L, Suresh KB, Pal M, Saha BP (2000) Evaluation of diuretic potentials of Jussiaea suffruticosa Linn extracts in rats. Indian J Pharma Sci 62:150–151

    Google Scholar 

  • OECD (2001) Guidline for testing of chemicals. 425:1–26

  • Ratrasooriya WD, Pieris KP, Samaratunga U, Jayakody JR (2004) Diuretic activity of Spilanthus acmella flowers in rats. J Ethnopharmacol 91:317–320

    Article  Google Scholar 

  • Satoa M, Nakayama T, Soma M, Aoia N, Kusugeb K, Haketab A et al. (2007) Association between prostaglandin E2 receptor gene and essential hypertension prostaglandins, leukotrienes and essential fatty acids 77: 15–20

  • Soleimani M, Barone S, Xu J, Shull GE, Siddiqui F, Zahedi K, Amlal H (2012) Double knockout of pendrin and Na-Cl co-transporter (NCC) causes severe salt wasting, volume depletion, and renal failure. Proc Natl Acad Sci U S A 109:13368–13373

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Somova LI, Shode FO, Ramanan P, Nadar A (2003) Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Oleaeuropaea subspecies Africana leaves. J Ethanopharmacol 84:299–305

    Article  CAS  Google Scholar 

  • Stanic G, Samarzija I, Blazevic N (1998) Time dependent diuretic response in rats treated with Juniper berry preparations. Phytotherap Res 12:494–97

    Article  Google Scholar 

  • Twaij HAA, Elisha EE, Al-Jeboory AA (1985) Screening of Iraqi medicinal plants for diuretic activity. Indian J Pharmac 17:73–76

  • Venkateshwarlu E, Sharvana BS, Umasankar K, Venkateshwar Rao J (2013) Evaluation of diuretic activity of Isatin derivatives in Wistar rats. J Pharm Nutri Sci 3:141–148

    CAS  Google Scholar 

  • Whelton A, Hamilton CW (1991) Nonsteroidal anti-inflammatory drug: effects on kidney function. J Cli Pharmacol 31:588–598

    Article  CAS  Google Scholar 

  • Yasar S, Lin FM, Fried LP, Kawas CH, Sink KM, DeKosky ST, Carlson MC (2012) Diuretic use is associated with better learning and memory in older adults in the Ginkgo evaluation of memory study. Alzheimers Dement 8:188–19

    Article  PubMed Central  CAS  PubMed  Google Scholar 

Download references

Conflict of Interests

No conflict of interests. No financial relationship with the organization that sponsored the research.

Author information

Authors and Affiliations

  1. Department of Pharmacology, Vaagdevi College of Pharmacy, Kishanpura, Hanamkonda, Warangal, Telangana State, 506001, India

    E. Venkateshwarlu, B. S. Sharvana Bhava, E. Gouthami & K. Umasankar

  2. Singhania University Pacheri, Jhunjhun, Rajastan, India

    R. Shiva Kumar

  3. Department of Chemistry, Talla Padmavathi College of Pharmacy, Ursu, Warangal, Telangana State, 506009, India

    Rao J. Venkateshwar

Authors
  1. E. Venkateshwarlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. S. Sharvana Bhava
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Shiva Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Rao J. Venkateshwar
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. Gouthami
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. K. Umasankar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. Venkateshwarlu.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Venkateshwarlu, E., Bhava, B.S.S., Kumar, R.S. et al. Evaluation of diuretic activity of Syzygium cumini and its effect on prostaglandin system. Orient Pharm Exp Med 15, 45–51 (2015). https://doi.org/10.1007/s13596-015-0179-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13596-015-0179-5

Keywords

Search

Navigation