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Evaluation of lyophilized extract of leaves of Tridax procumbens Linn. in rodent models of inflammatory and neuropathic pain

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Abstract

The aim of present study was to evaluate effect of lyophilized extract of Tridax procumbens Linn. in rodent models of inflammatory and neuropathic pain. The antiallodynic and antihyperalgesic activity of Tridax procumbens was assessed in Chronic Constriction Injury of Sciatic Nerve in rats (CCI) and Scald pain model in rats (burning pain) respectively at 100,200 and 400 mg/kg, p.o. In CCI model, the extract shows the dose dependent antiallodynic activity 60 min. post dose. In Scald pain model, extract shows the significant antihyperalgesic activity at 200 and 400 mg/kg at 60 and 90 min. post dose. The lyophilized extract of Tridax procumbens was found to be effective in neuropathic and inflammatory pain, suggesting its possible action via peripheral mechanisms. The activity may be attributed to the presence of flavonoids such as Quercetin.

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Acknowledgments

We would like to thank Jubilant Biosys Ltd, Drug Discovery Center Bangalore, India for providing the necessary facilities to carry out the research.

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Authors and Affiliations

  1. Jubilant Biosys Ltd, #96, Industrial suburb, 2nd stage, Yeshwanthpur, Bangalore, 560022, Karnataka, India

    Sudarshan Sawant, Virendra Chine, Annasaheb Kalange, Parag Joshi, Vaibhavkumar Gawali, Shuvranshu Narayan Praharaj & Masood Siddiqui

  2. Maharashtra College of Pharmacy, Nilanga, Maharashtra, India

    Chandraprabhu Jangme

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  1. Sudarshan Sawant
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  2. Virendra Chine
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  3. Annasaheb Kalange
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  4. Parag Joshi
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  5. Vaibhavkumar Gawali
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  6. Shuvranshu Narayan Praharaj
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  7. Chandraprabhu Jangme
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  8. Masood Siddiqui
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Correspondence to Sudarshan Sawant.

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Sawant, S., Chine, V., Kalange, A. et al. Evaluation of lyophilized extract of leaves of Tridax procumbens Linn. in rodent models of inflammatory and neuropathic pain. Orient Pharm Exp Med 14, 163–167 (2014). https://doi.org/10.1007/s13596-013-0143-1

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  • DOI: https://doi.org/10.1007/s13596-013-0143-1

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