Advertisement

Medicinal use of Coscinium fenestratum (Gaertn.) Colebr.: an short review

  • Ravishankar V. Rai
  • P. S. Rajesh
  • Hyung-Min Kim
Review Article

Abstract

The increasing in drug/antibiotics resistance by microorganisms finds the search for the new drugs with better results. Coscinium fenestratum considered as a critically endangered medicinal plant belongs to the family Menispermaceae. It is commonly found in Western Ghats of India and Sri Lanka. It is one among the families having several medicinal values from root to fruit. In the traditional medicine system, the plant has been used for treating diabetes mellitus and commonly known to be active ingredients with diverse therapeutic purposes. The stem of the plant has anti-microbial, anti-diabetic, anti-inflammatory, anti-oxidants properties and used for curing diseases . The root of Coscinium fenestratum is considered to be a bitter tonic, used in dressing wounds, treating ulcers and used as stomachic and antiseptic. The extract of the stem is useful in snake-bites and the stem bark is useful in treating intermittent fevers. This plant is used in combination with other medicinal plants, in the traditional methods of treating herpes in coastal Karnataka, India.

Keywords

Coscinium fenestratum Medicinal uses Antidiabetic Antimicrobial Western Ghats 

References

  1. Ali SS, Kasoju N, Luthra A, Singh A, Sharanabasava H, Sahu A, Bora U (2008) Indian medicinal herbs as sources of antioxidants. Food Res Int 41:1–15CrossRefGoogle Scholar
  2. Al-Reza SA, Rahman A, Sattar MA, Rahman MO, Fida HM (2010) Essential oil composition and antioxidant activities of Curcuma aromatica Salisb. Food Chem Toxicol 48:1757–1760PubMedCrossRefGoogle Scholar
  3. Anitha S, Suresh GS, Ramaiah M, Vaidya VP (2011) Extraction, isolation and wound healing activity of flavonoid from Coscinium fenestratum. Res J Pharm Biol Chem Sci 2:1090–1095Google Scholar
  4. Azadbakhta M, Safapour S, Ahmadi A, Ghasemi M, Shokrzadeh M (2010) Anti-diabetic effects of aqueous fruits extract of Diospyros lotus L. on streptozotocin-induced diabetic rats and the possible morphologic changes in the liver, kidney and heart. J Pharmacogn Phytother 2:010–016Google Scholar
  5. Ball AR, Casadei G, Samosorn S, Bremner JB, Ausubel FM, Moy TI, Lewis K (2006) Conjugating berberine to a multidrug resistance pump inhibitor creates an effective antimicrobial. ACS Chem Biol 9:594–600CrossRefGoogle Scholar
  6. Bhagath K, Prashith kekuda TR, Raghavendra HL, Swarnalatha SP, Preethi HR, Surabhi KS (2010) In vitro antioxidant and antihelmintic activity of extracts of Jasminium arborescens Roxb. Int J Drug Dev Res 2:89–95Google Scholar
  7. Bhandary MJ, Chandrashekar KR (2011) Herbal therapy for herpes in the ethano-medicine of Coastal Karnataka. Indian J Tradit Knowl 10:528–532Google Scholar
  8. Birdsall TC, Kelly GS (1997) Berberine: therapeutic potential of an alkaloid found in several medicinal plants. Alt Med Rev 2:94–103Google Scholar
  9. Cernakova M, Kostalova D (2002) Antimicrobial activity of berberine- a constituent of Mahonia aquifolium. Folia Microbiol 47:375–378CrossRefGoogle Scholar
  10. Chaudhary S (2010) Antiacne activity of some Indian herbal drugs. Int J Pharm Prof Res 1:78–80Google Scholar
  11. Chitra K, Sujatha K, Polisetti H, Karri S, Reddy CU (2011) Standardization of Coscinium fenestratum with reference to berberine by high performance thin layer chromatography. Res J Pharm Biol Chem Sci 2:226–229Google Scholar
  12. Choi B, Ahn I, Kim Y, Park J, Lee S, Hyun C, Do M (2006) Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte. Exp Mol Med 38:599–605PubMedCrossRefGoogle Scholar
  13. Costa A, Lage D, Moises TA (2010) Acne and diet: truth or myth? An Bras Dermatol 85:346–353PubMedCrossRefGoogle Scholar
  14. Cowan MM (1999) Plant products as antimicrobial agents. Clin Microbiol Rev 12:564–582PubMedGoogle Scholar
  15. Deevanhxay P, Suzuki M, Maeshibu N, Li H, Tanaka K, Hirose S (2009) Simultaneous characterization of quaternary alkaloids, 8-oxoprotoberberine alk aloids, and a steroid compound in Coscinium fenestratum by liquid chromatography hybrid ion trap time-of-flight mass spectrometry. J Pharm Biomed Anal 50:413–425PubMedCrossRefGoogle Scholar
  16. Dorman HJD, Deans SG (2000) Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 88:308–316PubMedCrossRefGoogle Scholar
  17. Eldeen IMS, Seow EM, Abdullah, Sulaiman SF (2011) In vitro antibacterial, antioxidant, total phenolic contents and anti-HIV-1 reverse transcriptase activities of extracts of seven Phyllanthus sp. S Afr J Bot 75–79Google Scholar
  18. Eswani N, Kudus KA, Nazre M, Noor AGA (2010) Medicinal plant diversity and vegetation analysis of logged over hill forest of tekai tembeling forest reserve, Jerantut, Pahang. J Agric Sci 2:189–210Google Scholar
  19. Freile ML, Giannini F, Pucci G, Sturniolo A, Rodero L, Pucci O, Balzareti V, Enriz RD (2003) Antimicrobial activity of aqueous extracts and of berberine isolated from Berberis heterophylla. Fitoterapia 74:702–705PubMedCrossRefGoogle Scholar
  20. Harisaranraj RS, Babu S, Suresh K (2010) Antimicrobial properties of selected Indian medicinal plants against acne-inducing bacteria. Ethnobot Leafl 14:84–94Google Scholar
  21. Isimi C, Obidike I, Aboh M, Emeje M (2011) Anti-plasmodial activity of the mixed stem bark extracts of Anogeissus leiocarpus and Prosopis africana and in vitro evaluation of its tablet dosage form. J Herbs Spices Med Plants 17:419–435CrossRefGoogle Scholar
  22. Jian-ling JIN, Guo-qiang HUA, Zhen MENG, Pei-ji GAO (2010) Antibacterial mechanisms of berberine and reasons for little resistance of bacteria. Chin Herb Med 3:27–35Google Scholar
  23. Kamkaen N, Wilkinson JM, Cavanagh HMA (2006) Cytotoxic effect of four Thai edible plants on mammalian cell proliferation. Thail Pharm Health Sci J 3:189–195Google Scholar
  24. Keawpradub N, Dej-adisai S, Yuenyongsawad S (2005) Antioxidant and cytotoxic activities of Thai medicinal plants named Khaminkhruea: Arcangelisia flava, Coscinium blumeanum and Fibraurea tinctoria. Songklanakarin. J Sci Technol 27:455–467Google Scholar
  25. Kekuda PTR, Sudharshan SJ, Chinmaya A, Valleesha NC, Murthuza S, Achur RN (2009) Central nervous system (CNS) depressant and Analgesic activity of methanolic extracts of Nardostachys jatamansi DC. and Coscinium fenestratum Colebr. in experimental animal model. J Pharm Res 2:1716–1719Google Scholar
  26. Khan T, Krupadanam D, Anwar SY (2008) The role of phytohormone on the production of berberine in the calli cultures of an endangered medicinal plant, turmeric (Coscinium fenestratum). African J Biotechnol 7:3244–3246Google Scholar
  27. Koffi N, Noel ZG, Theodore ED (2009) Hypotensive effect of aqueous extract of Bambusa vulgaris sheets on the arterial pressure of rabbits. Am J Sci Res 2:60–72Google Scholar
  28. Krishnaraju AV, Rao CBM, Sundararaju D, Sengupta K, Trimurtulu G (2009) Anti-inflammatory activity of Vitex leucoxylon L. bark extracts against Freund’s complete adjuvant induced arthritis in Sprague Dawley rat. Am J Infect Dis 5: 68–73Google Scholar
  29. Kumar GS, Jayaveera KN, Ashok Kumar CK, Sanjay UP, Vrushabendra Swamy BM, Kishore Kumar DV (2007) Antimicrobial effects of Indian medicinal plants against acne-inducing bacteria. Trop J Pharm Res 6:717–723Google Scholar
  30. Kumar S, Kumar V, Prakash O (2011) Antidiabetic, hypolipidemic, and antioxidant activities of Callistemon lanceolatus leaves extract. J Herbs Spices Med Plants 17:144–153CrossRefGoogle Scholar
  31. Li B, Birdwell C, Whelan J (1994) Antithetic relationship of dietary arachidonic acid and eicosapentaenoic acid on eicosanoid production in vivo. J Lipid Res 35:1869–1877PubMedGoogle Scholar
  32. Lin C, Kao S, Chen G, Chung J (2005) Berberine decreased N-acetylation of 2-aminofluorene through inhibition of N-acetyltransferase gene expression in human leukemia HL-60 cells. Anticancer Res 25:4149–4156PubMedGoogle Scholar
  33. Mahata S, Bharti AC, Shukla S, Tyagi A, Husain SA, Das BC (2011) Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells. Mol Cancer 1–14Google Scholar
  34. Malhotra S, Taneja SC, Dhar KL (1989) Minor alkaloid from Coscinium fenestratum. Phytochemy 28:1998–1999CrossRefGoogle Scholar
  35. Maritim C, Sanders RA, Watkins JB (2003) Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 17:24–38PubMedCrossRefGoogle Scholar
  36. Mohan MC, Smitha PV (2011) Phytochemical composition and antimicrobial activity of three plant preparations used in folk medicine and their synergistic properties. J Herbs Spices Med Plants 17(4):339–350CrossRefGoogle Scholar
  37. Muralidhar A, Sudhakar Babu S, Ravi sankar T, Reddanna P, Reddy GV, Latha J (2010) Antiinflammatory activity of flavonoid fraction isolated from the stem bark of Butea monosperma (Lam): a mechanism based study. Int J Phytopharm 1:124–132Google Scholar
  38. Nair GM, Narasimhan S, Shuburaj S, Abraham TK (2005) Antibacterial effects of Coscinium fenestratum. Fitoterapia 76:585–587PubMedCrossRefGoogle Scholar
  39. Narasimhan S, Nair GM (2004) Release of berberine and its crystallization in liquid medium of cell suspension cultures of Coscinium fenestratum (Gaertn.) Colebr. Curr Sci 86:1369–1371Google Scholar
  40. Nazeema TH, Brindha V (2009) Antihepatotoxic and antioxidant defense potential of Mimosapudica. Int J Drug Discov 1:01–04CrossRefGoogle Scholar
  41. Neelesh M, Jain S, Malviya S (2010) Antidiabetic potential of medicinal plants. Acta Pol Pharm Drug Res 67:113–118Google Scholar
  42. Nolan LL, Labbe RG (2005) Future of natural products from plants in the struggle with emerging diseases: case of food-borne pathogens and leishmaniasis. J Herbs Spices Med Plants 11:161–190CrossRefGoogle Scholar
  43. Okoli CO, Akah PA, Nwafor SV, Ihemelandu UU, Amadife C (2007) Anti-inflammatory activity of seed extracts of Aframomum melegueta. J Herbs Spices Med Plants 1:11–21CrossRefGoogle Scholar
  44. Oparaocha ET, Okorie C (2009) In vivo evaluation of anti-malarial activity of three medicinal plants used in South Eastern Nigeria. J Herbs Spices Med Plants 15(1):121–128CrossRefGoogle Scholar
  45. Parekh J, Chanda S (2007) Evaluation of antimicrobial activity of Terminalia chebula Retz. Fruit in different solvents. J Herbs Spices Med Plants 13:107–116CrossRefGoogle Scholar
  46. Pinho PMM, Pinto MMM, Kijjoa A, Pharadai K, Díaz JG, Herz W (1992) Protoberberine alkaloids from Coscinium fenestratum. Phytochem 31:1403–1407CrossRefGoogle Scholar
  47. Punitha ISR, Rajendran K, Shirwaikar A, Shirwaikar A (2005) Alcoholic stem extract of Coscinium fenestratum regulates carbohydrate metabolism and improves antioxidant status in streptozotocin-nicotinamide induced diabetic rats. Adv Access Public 2:375–381Google Scholar
  48. Rojsanga P, Gritsanapan W, Suntornsuk L (2006) Determination of berberine content in the stem extracts of Coscinium fenestratum by TLC densitometry. Med Princ Pract 15:373–378PubMedCrossRefGoogle Scholar
  49. Ruan K, Cervantes V, So S (2009) Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2 protein engineering. Des Sel 22:733–740Google Scholar
  50. Salahdeen HM, Yemitan OK, Alada ARA (2004) Effect of aqueous leaf extract of Tridax procumbens on blood pressure and heart rate in rats. Afr J Biomed Res 7: 27–29Google Scholar
  51. Samosorn S, Tanwirat B, Muhamad N, Casadei G, Tomkiewicz D, Lewis K, Suksamrarn A, Prammananan T, Gornall KC, Beck JL, Bremner JB (2009) Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group. Bioorg Med Chem 17:3866–3872PubMedCrossRefGoogle Scholar
  52. Saravanan R, Ramesh B, Pugalendi KV (2006) Effect of Piper betle on hepatotoxicity and antioxidant defense in ethanol-treated rats. J Herbs Spices Med Plants 12:61–72CrossRefGoogle Scholar
  53. Selvam ABD (2010) Is the term substitution relevant to pharmacognosy and/or vegetable crude drug industry? Pharmacogn Res 2:323–324Google Scholar
  54. Severina II, Muntyan MS, Lewis K, Skulachev VP (2001) Transfer of cationic antibacterial agents berberine, palmatine, and benzalkonium through bimolecular planar phospholipid film and Staphylococcus aureus membrane. IUBMB Life 52:321–324PubMedCrossRefGoogle Scholar
  55. Shirwaikar A, Rajendran K, Punitha ISR (2005a) Antihyperglycaemic activity of the aqueous stem extract of Coscinium fenestratum in non-insulin dependent diabetic rats. Pharm Biol 43:707–712CrossRefGoogle Scholar
  56. Shirwaikar A, Rajendran K, Punitha ISR (2005b) Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-nicotinamide induced type 2 diabetic rats. J Ethnopharmacol 97:369–374PubMedCrossRefGoogle Scholar
  57. Singh GB, Singh S, Bani S, Malhotra S (1990) Hypotensive action of a Coscinium fenestratum stem extract. J Ethnopharmacol 30:151–155PubMedCrossRefGoogle Scholar
  58. Singh MP, Bhaduaria RS, Sharma CS (2010) Neuromuscular blocking agents (NMBAs): an overview. J Chem Pharm Res 2:264–273Google Scholar
  59. Siva R (2007) Status of natural dyes and dye-yielding plants in India. Curr Sci 92:916–925Google Scholar
  60. Steriti R (2010) Berberine for diabetes mellitus type 2. Nat Med J 2:5–6Google Scholar
  61. Stermitz FR, Lorenz P, Tawara JN, Zenewicz LN, Lewis K (2000) Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5-methoxyhydnocarpin, a multidrug pump inhibitor. Appl Biol Sci 97:1433–1437Google Scholar
  62. Sudharshan SJ, Prashith TR, Sujatha ML (2010) Antiinflammatory activity of Curcuma aromatica Salisb and Coscinium fenestratum Colebr: a comparative study. J Pharm Res 3:24–25Google Scholar
  63. Suseela V, Poornima K (2009) Free radical scavenging activity of tree turmeric (Coscinium fenestratum). Indian J Nutr Diet 46:199–203Google Scholar
  64. Talib WH, Mahasneh AM (2010) Antiproliferative activity of plant extracts used against cancer in traditional medicine. Sci Pharm 78:33–45PubMedCrossRefGoogle Scholar
  65. Tomkiewicz D, Casadei G, Larkins-Ford J, Moy TI, Garner JA, Bremner JB, Ausubel FM, Lewis K, Kelso MJ (2010) Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components. Antimicrob Agents Chemother 54:3219–3224PubMedCrossRefGoogle Scholar
  66. Tran QL, Tezuka Y, Ueda J, Nguyen NT, Maruyama Y, Begum K, Kim H, Wataya Y, Tran QK, Kadota S (2003) In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine. J Ethnopharmacol 86:249–252PubMedCrossRefGoogle Scholar
  67. Tungpradit R, Sinchaikul S, Phutrakul S, Wongkham W, Chen S (2011) Antiproliferative activity of berberine from Coscinium fenestratum on NCI-H838 cell line. Chiang Mai J Sci 38:85–94Google Scholar
  68. Tushar KV, George S, Ramashree AB, Balachandran I (2008) Coscinium fenestratum (Gaertn.) Colebr.- A review on this rare, critically endangered and highly-traded medicinal species. J Plant Sci 3:133–145CrossRefGoogle Scholar
  69. Ueda J, Tezuka Y, Banskota AH, Tran QL, Tran QK, Saiki I, Kadota S (2002) Antiproliferative activity of vietnamese medicinal plants. Biol Pharm Bull 25:753–760PubMedCrossRefGoogle Scholar
  70. Umamaheswari S, Prathiba D, Srikanth J, Reddy U (2009) Antioxidant potential of a polyherbal formulation (Diabet) on alloxan induced oxidative stress in rats. Drug Invent Today 1:46–49Google Scholar
  71. Venukumar MR, Latha MS (2002) Antioxidant effect of Coscinium fenestratum in carbon tetrachloride treated rats. Indian J Physiol Pharmacol 46:223–228PubMedGoogle Scholar
  72. Venukumar MR, Latha MS (2004) Effect of Coscinium fenestratum on hepatotoxicity in rats. Indian J Exp Biol 42:792–797PubMedGoogle Scholar
  73. Vicente E, Charnaud S, Bongard E, Villar R, Burguete A, Solano B, Ancizu S, Perez-Silanes S, Aldana I, Vivas L, Monge A (2008) Synthesis and antiplasmodial activity of 3-Furyl and 3-Thienylquinoxaline-2-carbonitrile 1,4-Di-N-oxide Derivatives. Molecules 13:69–77PubMedCrossRefGoogle Scholar
  74. Wang X, Yao X, Zhu Z, Tang T, Dai K, Sadovskaya I, Flahaut S, Jabbouri S (2009) Effect of berberine on Staphylococcus epidermidis biofilm formation. Int J Antimicrob Agents 34:60–66PubMedCrossRefGoogle Scholar
  75. Wattanathorn J, Uabundit N, Itarat W, Mucimapura S, Laopatarakasem P, Sripanidkulchai B (2006) Neurotoxicity of Coscinium fenestratum stem, a medicinal plant used in traditional medicine. Food Chem Toxicol 44:1327–1333PubMedCrossRefGoogle Scholar
  76. Watthanachaiyingcharoen R, Komatsu K, Zhu S, Vajragupta O, Leelamanit W (2010) Authentication of Coscinium fenestratum among the other Menispermaceae plants prescribed in Thai folk medicines. Biol Pharm Bull 33:91–94PubMedCrossRefGoogle Scholar
  77. Wongbutdee J (2009) Physiological effects of berberine. Thail Pharm Health Sci J 4:78–83Google Scholar
  78. Wongcome T, Panthong A, Jesadanont S, Kanjanapothi D, Taesotikul T, Lertprasertsuke N (2007) Hypotensive effect and toxicology of the extract from Coscinium fenestratum (Gaertn) Colebr. J Ethnopharmacol 111:468–475PubMedCrossRefGoogle Scholar
  79. Yibchok-anun S, Jittaprasatsin W, Somtir D, Bunlunara W, Adisakwattana S (2009) Insulin secreting and α-glucosidase inhibitory activity of Coscinium fenestratum and postprandial hyperglycemia in normal and diabetic rats. J Med Plants Res 3:646–651Google Scholar
  80. Yin J, Gao Z, Liu D, Liu Z, Ye J (2008) Berberine improves glucose metabolism through induction of glycolysis. Am J Physiol Endocrinol Metab 294:E148–E156PubMedCrossRefGoogle Scholar

Copyright information

© Institute of Oriental Medicine, Kyung Hee University 2012

Authors and Affiliations

  • Ravishankar V. Rai
    • 1
  • P. S. Rajesh
    • 1
  • Hyung-Min Kim
    • 2
  1. 1.Department of Studies in MicrobiologyUniversity of MysoreMysoreIndia
  2. 2.Department of Pharmacology, College of Oriental Medicine, Institute of Oriental MedicineKyung Hee UniversitySeoulRepublic of Korea

Personalised recommendations