Abstract
The present study was carried out to investigate the anti-pyretic and anticonvulsant activity of petroleum ether, ethyl acetate, n-butanol and ethanol extracts of Smilax zeylanica Linn, leaves using experimental animal models. The extracts were screened for alkaloids, steroids, proteins, flavanoids, saponins, mucilage, carbohydrates, tannins, fats and oils. Anti-pyretic activity was evaluated using the brewer’s yeast-induced pyrexia in rats. The extracts in dose levels of 200 mg/kg orally were used for anti-pyretic studies. The petroleum ether extracts of leaves of Smilax zeylanica Linn produced significant (P < 0.01) anti-pyretic activity. Anticonvulsant activity of above extracts was evaluated by using strychnine induced tonic convulsion of Swiss albino mice. All extracts were able to reduce convulsion in mice. The Ethyl acetate extracts of Smilax zeylanica was found to have good anticonvulsant activity in comparison to other extracts which was verified as statistically significant by using one way ANOVA at 1% level of significance *shows P value < 0.01.
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Acknowledgement
Authors wish to thank to local people of Baipariguda and Biju Pattnayak Medicinal Plants Garden and Research Centre, Dr. M.S. Swami Nathan Research Foundation, Jeypore, Koraput (Dist), Orissa, for providing valuable information about the plant and its identification. Authors also wish to thanks School of Pharmaceutical Education and Research, Berhampur University, Ganjam, for providing facility to carry out this research work.
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Jena, P.K., Dinda, S.C. & Ellaiah, P. Phytochemical investigation and simultaneous study on antipyretic, anticonvulsant activity of different leafy extracts of smilax zeylanica Linn. Orient Pharm Exp Med 12, 123–127 (2012). https://doi.org/10.1007/s13596-011-0052-0
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DOI: https://doi.org/10.1007/s13596-011-0052-0
Keywords
- Smilax zeylanica
- Anti-pyretic
- Anticonvulsant
- Brewer’s yeast induced pyrexia
- Strychnine Hydrochloride
- Clonazepam.