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Boswellic acid suppresses cyclophosphamide induced chromosomal damage in mice

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Abstract

This study was performed to determine whether Boswellic acid suppresses genotoxicity induced by cyclophosphamide in mice. Genotoxicity was induced by the administration of cyclophosphamide (50 mg/kg) in swiss albino mice and was measured by counting the number of micronuclei and observing chromosomal aberration. In test group Boswellic acid was given in the dose of 200 mg/kg and various chromosomal aberration and formation of micronuclei were observed. Boswellic acid in dose of 200 mg/kg significantly (P < 0.001) inhibited the cyclophosphamide induced micronucleus formation and also significantly (P < 0.001) inhibited chromosomal aberrations in mice. Whereas Boswellic acid alone did not either induce formation of micronuclei or chromosomal aberration in mice. Boswellic acid itself doesn’t have any genotoxic effect and suppresses genotoxicity induced by cyclophosphamide.

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Acknowledgement

Authors are thankful to Council of Scientific and Industrial Research, New Delhi for the fellowship to Kuntal Ganguly (08/558(0001)/2010-EMRI).

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Authors and Affiliations

  1. Department of Pharmacology, SET’s College of Pharmacy, Dharwad, 580 002, India

    Kuntal Ganguly, N. V. Jagadeesh, Rakesh Singh, B. S. Thippeswami & Anandrao R. Kulkarni

  2. KLE University’s College of Pharmacy, Belgaum, 590 010, India

    Ashok D. Taranalli

Authors
  1. Kuntal Ganguly
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  2. N. V. Jagadeesh
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  3. Rakesh Singh
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  4. B. S. Thippeswami
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  5. Ashok D. Taranalli
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  6. Anandrao R. Kulkarni
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Correspondence to Anandrao R. Kulkarni.

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Ganguly, K., Jagadeesh, N.V., Singh, R. et al. Boswellic acid suppresses cyclophosphamide induced chromosomal damage in mice. Orient Pharm Exp Med 11, 177–181 (2011). https://doi.org/10.1007/s13596-011-0023-5

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  • DOI: https://doi.org/10.1007/s13596-011-0023-5

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