Dairy Science & Technology

, Volume 91, Issue 3, pp 247–282 | Cite as

Mastitis impact on technological properties of milk and quality of milk products—a review

  • Caroline Le Maréchal
  • Richard Thiéry
  • Eric Vautor
  • Yves Le Loir
Review Paper


The consequences of mastitis on the technological properties of milk and on the quality of milk products are widely reported in the literature. Besides, recent advances have shed light on the mechanisms involved in the udder response and subsequent milk changes in mastitis cases. This review gives an update on the literature regarding the impact of mastitis on milk composition and processing properties and collates recent data regarding the mechanisms involved in mastitis effects. It is an attempt to link field observations and experimental studies in order to better understand how mastites affect so dramatically the technological properties of milk. Both bovine and small ruminant milks are considered and a special emphasis is given on the role of staphylococci, streptococci, and Escherichia coli, the most common causative agents of mastitis.


Mastitis Milk Ruminant Dairy product Bacterial pathogen 



摘要 关于乳房炎对乳的加工特性和乳制品质量影响的文献报道非常多。近年来关于此方面的研究重点在乳房炎对乳房的反应以及对影响乳成分变化的机制。本文对近年来乳房炎对乳组成和加工特性的影响及其影响机制方面的相关文献进行了对比和分析。目的是说明乳房炎的发生会对乳的加工特性产生巨大的作用。不但是对牛乳, 而且一些小反刍动物乳的加工特性都受乳房炎的影响。值得强调的一个现象是葡萄球菌、链球菌属和大肠杆菌是乳房炎发病最主要的原因。


乳 反刍动物 乳制品 致病细菌 



Caroline Le Maréchal is the recipient of a Ph.D. grant from the Institut National de la Recherche Agronomique (INRA) and the Agence Nationale de Sécurité Sanitaire (ANSES), IMISa Project.


  1. Albenzio M, Caroprese M, Santillo A, Marino R, Taibi L, Sevi A (2004) Effects of somatic cell count and stage of lactation on the plasmin activity and cheese-making properties of ewe milk. J Dairy Sci 87:533–542Google Scholar
  2. Albenzio M, Caroprese M, Santillo A, Marino R, Muscio A, Sevi A (2005) Proteolytic patterns and plasmin activity in ewes’ milk as affected by somatic cell count and stage of lactation. J Dairy Res 72:86–92Google Scholar
  3. Ali EA, Andrews AT, Cheeseman GC (1980) Influence of elevated somatic cell count on casein distribution and cheese-making. J Dairy Res 47:393–400Google Scholar
  4. Alichanidis E, Polychroniadou A (1995) Special features of dairy products from ewe and goat milk from the physiochemicaland organoleptic point of view. In: IDF Greek National Committee of IDF CIRVAL Seminar, Creta, Greece, 21-10-1995, 122–127Google Scholar
  5. Alichanidis E, Wrathall JHM, Andrews AT (1986) Heat-stability of plasmin (milk proteinase) and plasminogen. J Dairy Res 53:259–269Google Scholar
  6. Alluwaimi AM, Leutenegger CM, Farver TB, Rossitto PV, Smith WL, Cullor JS (2003) The cytokine markers in Staphylococcus aureus mastitis of bovine mammary gland. J Vet Med B Infect Dis Vet Public Health 50:105–111Google Scholar
  7. Almeida RA, Oliver SP (1995) Invasion of bovine mammary epithelial cells by Streptococcus dysgalactiae. J Dairy Sci 78:1310–1317Google Scholar
  8. Anderson M (1982) Factors affecting the distribution of lipoprotein lipase activity between serum and casein micelles in bovine milk. J Dairy Res 49:51–59Google Scholar
  9. Anderson M, Andrews AT (1977) Progressive changes in individual milk protein concentrations associated with high somatic cell counts. J Dairy Res 44:223–235Google Scholar
  10. Andreatta E, Fernandes AM, dos Santos MV, de Lima CG, Mussarelli C, Marquesi MC, de Oliveira CAF (2007) Effects of milk somatic cell count on physical and chemical characteristics of mozzarella cheese. Aust J Dairy Technol 62:166–170Google Scholar
  11. Ariznabarreta A, Gonzalo C, San Primitivo F (2002) Microbiological quality and somatic cell count of ewe milk with special reference to staphylococci. J Dairy Sci 85:1370–1375Google Scholar
  12. Ashworth US, Forster TL, Luedecke LO (1967) Relationship between California mastitis test reaction and composition of milk from opposite quarters. J Dairy Sci 50:1078–1082Google Scholar
  13. Auldist MJ, Hubble IB (1998) Effects of mastitis on raw milk and dairy products. Aust J Dairy Technol 53:28–36Google Scholar
  14. Auldist MJ, Coats S, Rogers GL, McDowell GH (1995) Changes in the composition of milk from normal and mastitic dairy cows during the lactation cycle. Aust J Exp Agric 35:427–436Google Scholar
  15. Auldist MJ, Coats S, Sutherland BJ, Mayes JJ, McDowell GH, Rogers GL (1996) Effects of somatic cell count and stage of lactation on raw milk composition and the yield and quality of Cheddar cheese. J Dairy Res 63:269–280Google Scholar
  16. Azzara CD, Dimick PS (1985a) Lipolytic enzyme-activity of macrophages in bovine mammary-gland secretions. J Dairy Sci 68:1804–1812Google Scholar
  17. Azzara CD, Dimick PS (1985b) Lipoprotein lipase activity of milk from cows with prolonged subclinical mastitis. J Dairy Sci 68:3171–3175Google Scholar
  18. Bachman KC, Hayen MJ, Morse D, Wilcox CJ (1988) Effect of pregnancy, milk yield, and somatic cell count on bovine milk fat hydrolysis. J Dairy Sci 71:925–931Google Scholar
  19. Ballou LU, Pasquini M, Bremel RD, Everson T, Sommer D (1995) Factors affecting herd milk composition and milk plasmin at four levels of somatic cell counts. J Dairy Sci 78:2186–2195Google Scholar
  20. Bank U, Ansorge S (2001) More than destructive: neutrophil-derived serine proteases in cytokine bioactivity control. J Leukoc Biol 69:197–206Google Scholar
  21. Bannerman DD (2009) Pathogen-dependent induction of cytokines and other soluble inflammatory mediators during intramammary infection of dairy cows. J Anim Sci 87:10–25Google Scholar
  22. Bannerman DD, Paape MJ, Goff JP, Kimura K, Lippolis JD, Hope JC (2004a) Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis. Vet Res 35:681–700Google Scholar
  23. Bannerman DD, Paape MJ, Lee JW, Zhao X, Hope JC, Rainard P (2004b) Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infection. Clin Diagn Lab Immunol 11:463–472Google Scholar
  24. Bannerman DD, Paape MJ, Chockalingam A (2006) Staphylococcus aureus intramammary infection elicits increased production of transforming growth factor-α, β1, and β2. Vet Immunol Immunopathol 112:309–315Google Scholar
  25. Bansal BK, Hamann J, Grabowskit NT, Singh KB (2005) Variation in the composition of selected milk fraction samples from healthy and mastitic quarters, and its significance for mastitis diagnosis. J Dairy Res 72:144–152Google Scholar
  26. Baranova VS, Belov AD (1993) Cow milk proteins during mastitis infections. Voprosy Vet Biol 33–35Google Scholar
  27. Barbano DM, Rasmussen RR, Lynch JM (1991) Influence of milk somatic-cell count and milk age on cheese yield. J Dairy Sci 74:369–388Google Scholar
  28. Barbano DM, Ma Y, Santos MV (2006) Influence of raw milk quality on fluid milk shelf life. J Dairy Sci 89:E15–E19Google Scholar
  29. Bareille N, Beaudeau F, Billon S, Robert A, Faverdin P (2003) Effects of health disorders on feed intake and milk production in dairy cows. Livest Prod Sci 83:53–62Google Scholar
  30. Barlowska J, Litwinczuk Z, Wolanciuk A, Brodziak A (2009) Relationship of somatic cell count to daily yield and technological usefulness of milk from different breeds of cows. Pol J Vet Sci 12:75–79Google Scholar
  31. Barrett FM, Kelly AL, McSweeney PLH, Fox PF (1999) Use of exogenous urokinase to accelerateproteolysis in Cheddar cheese during ripening. Int Dairy J 9:421–427Google Scholar
  32. Bartlett PC, van Wijk J, Wilson DJ, Green CD, Miller GY, Majewski GA, Heider LE (1991) Temporal patterns of lost milk production following clinical mastitis in a large Michigan Holstein herd. J Dairy Sci 74:1561–1572Google Scholar
  33. Bastian ED, Brown RJ (1996) Plasmin in milk and dairy products: an update. Int Dairy J 6:435–457Google Scholar
  34. Bastian ED, Hansen KG, Brown RJ (1991) Activation of plasmin with urokinase in ultrafilteredmilk for cheese manufacture. J Dairy Sci 74:3669–3676Google Scholar
  35. Baudry C, de Cremoux R, Chartier C, Perrin G (1997) Impact of mammary gland inflammation on milk yield and composition in goats. Vet Res 28:277–286Google Scholar
  36. Bayles KW, Wesson CA, Liou LE, Fox LK, Bohach GA, Trumble WR (1998) Intracellular Staphylococcus aureus escapes the endosome and induces apoptosis in epithelial cells. Infect Immun 66:336–342Google Scholar
  37. Benfeldt C, Sørensen J, Ellegård K, Petersen TE (1997) Heat treatment of cheese milk: effect on plasmin activity and proteolysis during cheese ripening. Int Dairy J 7:723–731Google Scholar
  38. Berge A, Sjobring U (1993) PAM, a novel plasminogen-binding protein from Streptococcus pyogenes. J Biol Chem 268:25417–25424Google Scholar
  39. Bergonier D, Lagriffoul G, Berthelot X, Barillet F (1994) Facteurs de variation non infectieux des comptages cellules somatiques chez les ovins et caprines laitiers. In: Proc. Int. Symp. Somatic Cells and Milk of Small Ruminants, Bella, Italy, 25-9-1994, 1–20Google Scholar
  40. Bergonier D, de Cremoux R, Rupp R, Lagriffoul G, Berthelot X (2003) Mastitis of dairy small ruminants. Vet Res 34:689–716Google Scholar
  41. Bester BH, Lombard SH (1990) Influence of lysozyme on selected bacteria associated with Gouda cheese. J Food Prot 53:306–311Google Scholar
  42. Bianchi L, Bolla A, Budelli E, Caroli A, Casoli C, Pauselli M, Duranti E (2004) Effect of udder health status and lactation phase on the characteristics of Sardinian ewe milk. J Dairy Sci 87:2401–2408Google Scholar
  43. Boehmer JL, Bannerman DD, Shefcheck K, Ward JL (2008) Proteomic analysis of differentially expressed proteins in bovine milk during experimentally induced Escherichia coli mastitis. J Dairy Sci 91:4206–4218Google Scholar
  44. Bogin E, Ziv G (1973) Enzymes and minerals in normal and mastitic milk. Cornell Vet 63:666–676Google Scholar
  45. Bonnefoy A, Legrand C (2000) Proteolysis of subendothelial adhesive glycoproteins (fibronectin, thrombospondin, and von Willebrand factor) by plasmin, leukocyte cathepsin G, and elastase. Thromb Res 98:323–332Google Scholar
  46. Brink N, Lewis U, Williams D (1956) Pancreatic elastase: purification, properties, and function. J Biol Chem 222:705–720Google Scholar
  47. Bufano G, Dario C, Laudario V (1996) The characterisation of Leccese sheep: variations of chemical composition and lactodynamographic parameters in milk as related to somatic cell counts. In: Proceedings of the International Symposium of Somatic Cells and Milk of Small Ruminants 25–27 September 1996; Bella., Italy. 301–304Google Scholar
  48. Caffin JP, Poutrel B, Rainard P (1983) Physiological and pathological factors influencing bovine immunoglobulin G1 concentration in milk. J Dairy Sci 66:2161–2166Google Scholar
  49. Carlsson A, Bjorck L, Persson K (1989) Lactoferrin and lysozyme in milk during acute mastitis and their inhibitory effect in Delvotest P. J Dairy Sci 72:3166–3175Google Scholar
  50. Caruolo EV (1974) Milk yield, composition, and somatic cells as a function of time of day in goats under a continuous lighting regimen. Br Vet J 130:380–387Google Scholar
  51. Cerami A (1992) Inflammatory cytokines. Clin Immunol Immunopathol 62:S3–S10Google Scholar
  52. Chaneton L, Tirante L, Maito J, Chaves J, Bussmann LE (2008) Relationship between milk lactoferrin and etiological agent in the mastitic bovine mammary gland. J Dairy Sci 91:1865–1873Google Scholar
  53. Chen PW, Chen WC, Mao FCH (2004) Increase of lactoferrin concentration in mastitic goat milk. J Vet Med Sci 66:345–350Google Scholar
  54. Chen SX, Wang JZ, Van Kessel JS, Ren FZ, Zeng SS (2010) Effect of somatic cell count in goat milk on yield, sensory quality, and fatty acid profile of semisoft cheese. J Dairy Sci 93:1345–1354Google Scholar
  55. Chockalingam A, Paape MJ, Bannerman DD (2005) Increased milk levels of transforming growth factor-α, β1, and β2 during Escherichia coli-induced mastitis. J Dairy Sci 88:1986–1993Google Scholar
  56. Considine T, Healy A, Kelly AL, McSweeney PLH (1999) Proteolytic specificity of elastase on bovine β-casein. Food Chem 66:463–470Google Scholar
  57. Considine T, Healy A, Kelly AL, McSweeney PLH (2000) Proteolytic specificity of elastase on bovine αs1-casein. Food Chem 69:19–26Google Scholar
  58. Considine T, Geary S, Kelly AL, McSweeney PLH (2002a) Proteolytic specificity of cathepsin G on bovine αs1- and β-caseins. Food Chem 76:59–67Google Scholar
  59. Considine T, McSweeney PLH, Kelly AL (2002b) The effect of lysosomal proteinases and plasmin on the rennet coagulation properties of skim milk. Milchwissenschaft 57:425–428Google Scholar
  60. Considine T, Healy A, Kelly AL, McSweeney PLH (2004) Hydrolysis of bovine caseins by cathepsin B, a cysteine proteinase indigenous to milk. Int Dairy J 14:117–124Google Scholar
  61. Cooney S, Tiernan D, Joyce P, Kelly AL (2000) Effect of somatic cell count and polymorphonuclear leucocyte content of milk on composition and proteolysis during ripening of Swiss-type cheese. J Dairy Res 67:301–307Google Scholar
  62. Cooray R (1996) Casein effects on the myeloperoxidase-mediated oxygen-dependent bactericidal activity of bovine neutrophils. Vet Immunol Immunopathol 51:55–65Google Scholar
  63. Coulon JB, Gasqui P, Barnouin J, Ollier A, Pradel P, Pomies D (2002) Effect of mastitis and related-germ on milk yield and composition during naturally-occurring udder infections in dairy cows. Anim Res 51:383–393Google Scholar
  64. Dano K, Andreasen PA, Grondahl-Hansen J, Kristensen P, Nielsen LS, Skriver L (1985) Plasminogen activators, tissue degradation, and cancer. Adv Cancer Res 44:139–266Google Scholar
  65. de Haas Y, Barkema HW, Veerkamp RF (2002) The effect of pathogen-specific clinical mastitis on the lactation curve for somatic cell count. J Dairy Sci 85:1314–1323Google Scholar
  66. Devriese LA, Schleifer KH, Adegoke GO (1985) Identification of coagulase-negative staphylococci from farm animals. J Appl Bacteriol 58:45–55Google Scholar
  67. Diaz JR, Muelas R, Segura R, Peris CMP (1996) Effect of mastitis on milk composition in manchega ewes: preliminary results, in: Proceedings of the International Symposium of Somatic Cells and Milk of Small Ruminants 25–27 September 1996; Bella, Italy 305–309Google Scholar
  68. Djabri B, Bareille N, Beaudeau F, Seegers H (2002) Quarter milk somatic cell count in infected dairy cows: a meta-analysis. Vet Res 33:335–357Google Scholar
  69. Donelly WJ, Barry JG (1983) Casein compositional studies. III. Changes in Irish milk for manufacturing and role of milk protease. J Dairy Res 50:433Google Scholar
  70. Dufour D, Jameh N, Dary A, Le Roux Y (2009) Short communication: can the mammopathogenic Escherichia coli P4 strain have a direct role on the caseinolysis of milk observed during bovine mastitis? J Dairy Sci 92:1398–1403Google Scholar
  71. Duranti E, Casoli C (1991) Variations in the nitrogen composition and in the lactodinamographic parameters of ewe’s milk in relation to somatic cell content. Zootec Nutr Anim 17:99–105Google Scholar
  72. El-Saied UM, Carriedo JA, De la Fuente LF, San Primitivo F (1999) Genetic parameters of lactation cell counts and milk and protein yields in dairy ewes. J Dairy Sci 82:639–644Google Scholar
  73. Emmons DB, Elliot JA, Beckett DC (1963) Agglutination of starter bacteria, sludge formation and slow acid development in cottage cheese manufacture. J Dairy Sci 46:600Google Scholar
  74. Emmons DB, Elliott JA, Beckett DC (1966) Effect of lactic-streptococcal agglutinins in milk on curd formation and manufacture of cottage cheese. J Dairy Sci 49:1361Google Scholar
  75. Erwin RE, Randolph HE (1975) Influence of mastitis on properties of milk. XI. Fat globule membrane. J Dairy Sci 58:9–12Google Scholar
  76. Farkye NY, Fox PF (1992) Contribution of plasmin to Cheddar cheese ripening: effect of added plasmin. J Dairy Res 59:209–216Google Scholar
  77. Farkye NT, Landkammer CF (1992) Milk plasmin activity influence on cheddar cheese quality during ripening. J Food Sci 57:622–624Google Scholar
  78. Fernandes AM, Oliveira CAF, Lima CG (2006) Effects of somatic cell counts in milk on physical and chemical characteristics of yoghurt. Int Dairy J 17:111–115Google Scholar
  79. Fernandes AM, Moretti TS, Bovo F, Lima CG, Oliveira CAF (2008) Effect of somatic cell counts on lipolysis, proteolysis and apparent viscosity of UHT milk during storage. Int J Dairy Technol 61:327–332Google Scholar
  80. Fitz-Gerald CH, Deeth HC, Kitchen BJ (1981) The relationship between the levels of free fatty acids, lipoprotein lipase, carboxylesterase, N-acetyl-beta-d-glucosaminidase, somatic cell count and other mastitis indices in bovine milk. J Dairy Res 48:253–265Google Scholar
  81. Fox PF, McSweeney PLH (1996) Proteolysis in cheese. Food Rev Int 12:457–509Google Scholar
  82. Galina MA, Morales R, Lοpez B, Carmona MA (1996) Effect of somatic cell count on lactation and soft cheese yield by dairy goats. Small Rumin Res 21:251–257Google Scholar
  83. Gargouri A, Hamed H, El Feki A (2008) Total and differential bulk cow milk somatic cell counts and their relation with lipolysis. Livest Sci 113:274–279Google Scholar
  84. Gonzalo C, Carriedo JA, Gomez JD, Gomez LD, San PF (1994) Diurnal variation in the somatic cell count of ewe milk. J Dairy Sci 77:1856–1859Google Scholar
  85. Gonzalo C, Ariznabarreta A, Carriedo JA, San Primitivo F (2002) Mammary pathogens and their relationship to somatic cell count and milk yield losses in dairy ewes. J Dairy Sci 85:1460–1467Google Scholar
  86. Grandison AS, Ford GD (1986) Effects of variations in somatic cell count on the rennet coagulation properties of milk and on the yields, composition and quality of cheddar cheese. J Dairy Res 53:645–655Google Scholar
  87. Grazia LC, Castagnetti GB, Losi B (1984) Manufacture of Grana cheese with lysozyme. Acidification of whey and sensitivity of thermophilic lactic acid bacteria. Sci Tecn Latt Cas 35:384–393Google Scholar
  88. Griesbeck-Zilch B, Meyer HHD, Kuhn C, Schwerin M, Wellnitz O (2008) Staphylococcus aureus and Escherichia coli cause deviating expression profiles of cytokines and lactoferrin messenger ribonucleic acid in mammary epithelial cells. J Dairy Sci 91:2215–2224Google Scholar
  89. Grieve PA, Kitchen BJ (1985) Proteolysis in milk: the significance of proteinases originating from milk leucocytes and a comparison of the action of leucocyte, bacterial and natural milk proteinases on casein. J Dairy Res 52:101–112Google Scholar
  90. Grohn YT, Wilson DJ, Gonzalez RN, Hertl JA, Schulte H, Bennett G, Schukken YH (2004) Effect of pathogen-specific clinical mastitis on milk yield in dairy cows. J Dairy Sci 87:3358–3374Google Scholar
  91. Gunther J, Koczan D, Yang W, Nurnberg G, Repsilber D, Schuberth HJ, Park Z, Maqbool N, Molenaar A, Seyfert HM (2009) Assessment of the immune capacity of mammary epithelial cells: comparison with mammary tissue after challenge with Escherichia coli. Vet Res 40:31–45Google Scholar
  92. Haddadi K, Moussaoui F, Hebia I, Laurent F, Le Roux Y (2005) E.coli proteolytic activity in milk and casein breakdown. Reprod Nutr Dev 45:485–496Google Scholar
  93. Haddadi K, Prin-Mathieu C, Moussaoui F, Faure GC, Vangroenweghe F, Burvenich C, Le Roux Y (2006) Polymorphonuclear neutrophils and Escherichia coli proteases involved in proteolysis of casein during experimental E. coli mastitis. Int Dairy J 16:639–647Google Scholar
  94. Haenlein GF, Schultz LH, Zikakis JP (1973) Composition of proteins in milk with varying leucocyte contents. J Dairy Sci 56:1017–1024Google Scholar
  95. Hagiwara K, Yamanaka H, Hisaeda K, Taharaguchi S, Kirisawa R, Iwai H (2001) Concentrations of IL-6 in serum and whey from healthy and mastitic cows. Vet Res Commun 25:99–108Google Scholar
  96. Hagiwara S, Kawai K, Anri A, Nagahata H (2003) Lactoferrin concentrations in milk from normal and subclinical mastitic cows. J Vet Med Sci 65:319–323Google Scholar
  97. Hagnestam C, Emanuelson U, Berglund B (2007) Yield losses associated with clinical mastitis occurring in different weeks of lactation. J Dairy Sci 90:2260–2270Google Scholar
  98. Halasa T, Nielen M, Huirne RBM, Hogeveen H (2009) Stochastic bio-economic model of bovine intramammary infection. Livest Sci 124:295–305Google Scholar
  99. Harmon RJ, Schanbacher FL, Ferguson LC, Smith KL (1976) Changes in lactoferrin, immunoglobulin G, bovine serum albumin, and alpha-lactalbumin during acute experimental and natural coliform mastitis in cows. Infect Immun 13:533–542Google Scholar
  100. Hettinga KA, van Valenberg HJF, Lam TJGM, van Hooijdonk ACM (2009) The origin of the volatile metabolites found in mastitis milk. Vet Microbiol 137:384–387Google Scholar
  101. Hirano R, Hirano M, Oooka M, Dosako S, Nakajima I, Igoshi K (1998) Lactoperoxidase effects on rheological properties of yogurt. J Food Sci 63:35–38Google Scholar
  102. Hiss S, Meyer T, Sauerwein H (2008) Lactoferrin concentrations in goat milk throughout lactation. Small Rumin Res 80:87–90Google Scholar
  103. Hodgkinson A, Ross K, Fahey S, Prosser C (2008) Quantification of lactoferrin in milk from New Zealand dairy goats. In: Proceedings of the New Zealand Society of Animal Production 68th Conference, Brisbane, Australia, 24-6-2008, 166–169Google Scholar
  104. Hogarth CJ, Fitzpatrick JL, Nolan AM, Young FJ, Pitt A, Eckersall PD (2004) Differential protein composition of bovine whey: a comparison of whey from healthy animals and from those with clinical mastitis. Proteomics 4:2094–2100Google Scholar
  105. Hortet P, Seegers H (1998) Calculated milk production losses associated with elevated somatic cell counts in dairy cows: review and critical discussion. Vet Res 29:497–510Google Scholar
  106. Hurley WL, Aslam M, Hegarty HM, Morkoc A (1994) Synthesis of lactoferrin and casein by explants of bovine mammary tissue. Cell Biol Int 18:629–637Google Scholar
  107. Hurley MJ, Larsen LB, Kelly AL, McSweeney PLH (2000) The milk acid proteinase cathepsin D: a review. Int Dairy J 10:673–681Google Scholar
  108. Ip MM, Shoemaker SF, Darcy KM (1992) Regulation of rat mammary epithelial cell proliferation and differentiation by tumor necrosis factor-alpha. Endocrinology 130:2833–2844Google Scholar
  109. Jaeggi JJ, Govindasamy-Lucey S, Berger YM, Johnson ME, McKusick BC, Thomas DL, Wendorff WL (2003) Hard ewe’s milk cheese manufactured from milk of three different groups of somatic cell counts. J Dairy Sci 86:3082–3089Google Scholar
  110. Janota BL, Glabowna M (1982) Atomic absorption spectrophotometry of milk for prognosis of mastitis. Milchwissenschaft 37:13–16Google Scholar
  111. Jaubert G, Gay jacquin, Perrin G (1996) Somatic cell counts and biochemical and technological characteristics of goat milk. In: The International Symposium on Somatic Cells and Milk of Small Ruminants, Bella, italy, 25-9-1996, 263–268Google Scholar
  112. Kalit S, Havranek JL, Kaps M (2002) Plasminogen activation and somatic cell count (SCC) in cheese milk: influence on Podravec cheese ripening. Milchwissenschaft 57:380–382Google Scholar
  113. Kaminogawa S, Yamauchi K, Miyazawa S, Koga Y (1980) Degradation of casein components by acid protease of bovine-milk. J Dairy Sci 63:701–704Google Scholar
  114. Karlsson A, Arvidson S (2002) Variation in extracellular protease production among clinical isolates of Staphylococcus aureus due to different levels of expression of the protease repressor sarA. Infect Immun 70:4239–4246Google Scholar
  115. Kawai K, Hagiwara S, Anri A, Nagahata H (1999) Lactoferrin concentration in milk of bovine clinical mastitis. Vet Res Commun 23:391–398Google Scholar
  116. Kelly AL, O’Flaherty F, Fox PF (2006) Indigenous proteolytic enzymes in milk: a brief overview of the present state of knowledge. Int Dairy J 16:563–572Google Scholar
  117. Kitchen BJ (1981) Review of the progress of Dairy Science: bovine mastitis:milk compositional cahnges and related diagnostic tests. J Dairy Res 48:167–188Google Scholar
  118. Kitchen BJ, Middleton G, Durward IG, Andrews RJ, Salmon MC (1980) Mastitis diagnostic tests to estimate mammary gland epithelial cell damage. J Dairy Sci 63:978–983Google Scholar
  119. Kitchen BJ, Middleton G, Kwee WS, Andrews RJ (1984) N-Acetyl-beta-d-glucosaminidase (NAGase) levels in bulk herd milk. J Dairy Res 51:227–232Google Scholar
  120. Klei L, Yun J, Sapru A, Lynch J, Barbano D, Sears P, Galton D (1998) Effects of milk somatic cell count on cottage cheese yield and quality. J Dairy Sci 81:1205–1213Google Scholar
  121. Komine K, Kuroishi T, Komine Y, Watanabe K, Kobayashi J, Yamaguchi T, Kamata S, Kumagai K (2004) Induction of nitric oxide production mediated by tumor necrosis factor alpha on staphylococcal enterotoxin C-stimulated bovine mammary gland cells. Clin Diagn Lab Immunol 11:203–210Google Scholar
  122. Kushibiki S, Hodate K, Shingu H, Obara Y, Touno E, Shinoda M, Yokomizo Y (2003) Metabolic and lactational responses during recombinant bovine tumor necrosis factor-α treatment in lactating cows. J Dairy Sci 86:819–827Google Scholar
  123. Kuusela P, Saksela O (1990) Binding and activation of plasminogen at the surface of Staphylococcus aureus—increase in affinity after conversion to the lys form of the ligand. Eur J Biochem 193:759–765Google Scholar
  124. Kuusela P, Ullberg M, Kronvall G, Tervo T, Tarkkanen A, Saksela O (1992) Surface-associated activation of plasminogen on gram-positive bacteria - effect of plasmin on the adherence of Staphylococcus aureus. Acta Ophthalmol 70:42–46Google Scholar
  125. Lahteenmaki K, Kuusela P, Korhonen TK (2001) Bacterial plasminogen activators and receptors. FEMS Microbiol Rev 25:531–552Google Scholar
  126. Larsen LB, Benfeldt C, Rasmussen LK, Petersen TE (1996) Bovine milk procathepsin D and cathepsin D: coagulation and milk protein degradation. J Dairy Res 63:119–130Google Scholar
  127. Larsen LB, Wium H, Benfeldt C, Heegaard CW, Ardo Y, Qvist KB, Petersen TE (2000) Bovine milk procathepsin D: presence and activity in heated milk and in extracts of rennet-free UF-Feta cheese. Int Dairy J 10:67–73Google Scholar
  128. Larsen LB, Rasmussen MD, Bjerring M, Nielsen JH (2004) Proteases and protein degradation in milk from cows infected with Streptococcus uberis. Int Dairy J 14:899–907Google Scholar
  129. Larsen LB, McSweeney PLH, Hayes MG, Andersen JB, Ingvartsen KL, Kelly AL (2006) Variation in activity and heterogeneity of bovine milk proteases with stage of lactation and somatic cell count. Int Dairy J 16:1–8Google Scholar
  130. Laurinaviciute V, Siugzdaite J, Urbsienne D (2004) Quality and composition of milk with different somatic cell count of two breeds of dairy goats. Med Weter 60:1137–1248Google Scholar
  131. Le Mens P, Dalmas S, Humbert G (1996) Relations entre l’activité de la N-acetyl-glucosaminidase (NAG-ase), le nombre de cellules,l’aptitude à la coagulation du lait et le statut infectieux mammairechez la chèvre, In: Proceedings of the International Symposium on Somatic Cells and Milk of Small Ruminants, Bella,Italy, 25-9-1996, 311–312Google Scholar
  132. Le Roux Y, Colin O, Laurent F (1995) Proteolysis in samples of quarter milk with varying somatic cell counts. 1. Comparison of some indicators of endogenous proteolysis in milk. J Dairy Sci 78:1289–1297Google Scholar
  133. Le Roux Y, Laurent F, Moussaoui F (2003) Polymorphonuclear proteolytic activity and milk composition change. Vet Res 34:629–645Google Scholar
  134. Leavitt BE, Oleary J, Harmon RJ, Hicks CL (1982) Effect of mastitis on cheese yield, milk-production, milk-composition and starter culture activity. J Food Prot 45:1176Google Scholar
  135. Lee SC, Yu JH, Back YJ, Yoon YC (1991) The influence of mastitis on the quality of raw milk and cheese. Kor J Dairy Sci 13:217–223Google Scholar
  136. Lee JW, Paape MJ, Zhao X (2003) Recombinant bovine soluble CD14 reduces severity of experimental Escherichia coli mastitis in mice. Vet Res 34:307–316Google Scholar
  137. Lee JW, Bannerman DD, Paape MJ, Huang MK, Zhao X (2006) Characterization of cytokine expression in milk somatic cells during intramammary infections with Escherichia coli or Staphylococcus aureus by real-time PCR. Vet Res 37:219–229Google Scholar
  138. Lehtolainen T, Rontved C, Pyorala S (2004) Serum amyloid A and TNF alpha in serum and milk during experimental endotoxin mastitis. Vet Res 35:651–659Google Scholar
  139. Leitner G, Chaffer M, Caraso Y, Ezra E, Kababea D, Winkler M, Glickman A, Saran A (2003) Udder infection and milk somatic cell count, NAGase activity and milk composition-fat, protein and lactose-in Israeli-Assaf and Awassi sheep. Small Rumin Res 49:157–164Google Scholar
  140. Leitner G, Chaffer M, Shamay A, Shapiro F, Merin U, Ezra E, Saran A, Silanikove N (2004a) Changes in milk composition as affected by subclinical mastitis in sheep. J Dairy Sci 87:46–52Google Scholar
  141. Leitner G, Merin U, Silanikove N (2004b) Changes in milk composition as affected by subclinical mastitis in goats. J Dairy Sci 87:1719–1726Google Scholar
  142. Leitner G, Merin U, Silanikove N, Ezra E, Chaffer M, Gollop N, Winkler M, Glickman A, Saran A (2004c) Effect of subclinical intramammary infection on somatic cell counts, NAGase activity and gross composition of goats’ milk. J Dairy Res 71:311–315Google Scholar
  143. Leitner G, Krifucks O, Merin U, Lavi Y, Silanikove N (2006) Interactions between bacteria type, proteolysis of casein and physico-chemical properties of bovine milk. Int Dairy J 16:648–654Google Scholar
  144. Lemieux L, Simard RE (1994) Astringency, a textural defect in dairy-products. Lait 74:217–240Google Scholar
  145. Lincoln RA, Leigh JA (1998) Characterization of the interaction of bovine plasmin with Streptococcus uberis. J Appl Microbiol 84:1104–1110Google Scholar
  146. Long E, Capuco AV, Wood DL, Sonstegard T, Tomita G, Paape MJ, Zhao X (2001) Escherichia coli induces apoptosis and proliferation of mammary cells. Cell Death Differ 8:808–816Google Scholar
  147. Lucas PS (1962) What causes a spongy formation in cottage cheese? Am Milk Rev 24:74Google Scholar
  148. Lucey S, Rowlands GJ, Russell AM (1986) Short-term associations between disease and milk yield of dairy cows. J Dairy Res 53:7–15Google Scholar
  149. Lutzow YC, Donaldson L, Gray CP, Vuocolo T, Pearson RD, Reverter A, Byrne KA, Sheehy PA, Windon R, Tellam RL (2008) Identification of immune genes and proteins involved in the response of bovine mammary tissue to Staphylococcus aureus infection. BMC Vet Res 4:18Google Scholar
  150. Ma Y, Ryan C, Barbano DM, Galton DM, Rudan MA, Boor KJ (2000) Effects of somatic cell count on quality and shelf-life of pasteurized fluid milk. J Dairy Sci 83:264–274Google Scholar
  151. Manser PA (1986) Prevalence, causes and laboratory diagnosis of subclinical mastitis in the goat. Vet Rec 118:552–554Google Scholar
  152. Marino R, Considine T, Sevi A, McSweeney PLH, Kelly AL (2005) Contribution of proteolytic activity associated with somatic cells in milk to cheese ripening. Int Dairy J 15:1026–1033Google Scholar
  153. Mazal G, Vianna PCB, Santos MV, Gigante ML (2007) Effect of somatic cell count on Prato cheese composition. J Dairy Sci 90:630–636Google Scholar
  154. McSweeney PLH, Walsh EM, Fox PF, Cogan TM, Drinan FD, Castelo-Gonzalez M (1994) A procedure for the manufacture of cheddar cheese under controlled bacteriological conditions and the effect of adjunct lactobacilli on cheese quality. Ir J Agric Food Res 33:183–192Google Scholar
  155. McSweeney PLH, Fox PF, Olson NF (1995) Proteolysis of bovine caseins by cathepsin-D—preliminary-observations and comparison with chymosin. Int Dairy J 5:321–336Google Scholar
  156. Mebmer UK, Briner VA, Pfeilschifter J (1999) Tumor necrosis factor-a and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells. Kidney Int 55:2322–2337Google Scholar
  157. Merin U, Fleminger G, Komanovsky J, Silanikove N, Bernstein S, Leitner G (2008) Subclinical udder infection with Streptococcus dysgalactiae impairs milk coagulation properties: the emerging role of proteose peptones. Dairy Sci Technol 88:407–419Google Scholar
  158. Michelutti I, Le Roux Y, Rainard P, Poutrel B, Laurent F (1999) Sequential changes in milk protein composition after experimental Escherichia coli mastitis. Lait 79:535–549Google Scholar
  159. Miedzobrodzki J, Naidu AS, Watts JL, Ciborowski P, Palm K, Wadstrom T (1989) Effect of milk on fibronectin and collagen type I binding to Staphylococcus aureus and coagulase-negative staphylococci isolated from bovine mastitis. J Clin Microbiol 27:540–544Google Scholar
  160. Miller RH, Emanuelsson U, Persson E, Brolund E, Philipsson L, Funke H (1983) Relationships of milk somatic cell counts to daily milk yield and composition. Acta Agric Scand 33:209–223Google Scholar
  161. Mitchell GE, Rogers SA, Houlihan DB, Tucker VC, Kitchen BJ (1986) The relationshiop between somatic cell count, composition and manufacturing properties of bulk milk. 1. Composition of farm bulk milk. Aust J Dairy Technol 41:9–12Google Scholar
  162. Moir E, Booth NA, Bennett B, Robbie BA (2001) Polymorphonuclear leukocytes mediate endogenous thrombus lysis via a uPA-dependent mechanism. Brit J Haematol 113:72–80Google Scholar
  163. Morgan F, Gaspard CE (1999) Influence des cellules somatiques sur les qualités technologiques du lait de chèvre et sur les caractéristiques des fromages de chèvre, in: 6èmes journées Rencontres Recherches Ruminants, Paris, France, p 317Google Scholar
  164. Moussaoui F, Michelutti I, Le Roux Y, Laurent F (2002) Mechanisms involved in milk endogenous proteolysis induced by a lipopolysaccharide experimental mastitis. J Dairy Sci 85:2562–2570Google Scholar
  165. Moussaoui F, Laurent F, Girardet JM, Humbert G, Gaillard JL, Le Roux Y (2003) Characterization and proteolytic origins of specific peptides appearing during lipopolysaccharide experimental mastitis. J Dairy Sci 86:1163–1170Google Scholar
  166. Moussaoui F, Vangroenweghe F, Haddadi K, Le Roux Y, Laurent F, Duchateau L, Burvenich C (2004) Proteolysis in milk during experimental Escherichia coli mastitis. J Dairy Sci 87:2923–2931Google Scholar
  167. Muir DD (1996) The shelf-life of dairy products.1. Factors influencing raw milk and fresh products. J Soc Dairy Technol 49:24–32Google Scholar
  168. Munro GL, Grieve PA, Kitchen BJ (1984) Effects of mastitis on milk yield, milk composition, processing properties and yield and quality of milk products. Aust J Dairy Technol 39:7–16Google Scholar
  169. Murphy SC, Cranker K, Senyk GF, Barbano DM, Saeman AI, Galton DM (1989) Influence of bovine mastitis on lipolysis ond proteolysis in milk. J Dairy Sci 72:620–626Google Scholar
  170. Nabhan MA, Girardet JM, Campagna S, Gaillard JL, Le Roux Y (2004) Isolation and characterization of copolymers of β-lactoglobulin, α-lactalbumin, κ-casein, and α(S1)-casein generated by pressurization and thermal treatment of raw milk. J Dairy Sci 87:3614–3622Google Scholar
  171. Nakajima Y, Mikami O, Yoshioka M, Motoi Y, Ito T, Ishikawa Y, Fuse M, Nakano K, Yasukawa K (1997) Elevated levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) activities in the sera and milk of cows with naturally occurring coliform mastitis. Res Vet Sci 62:297–298Google Scholar
  172. Napoli A, Aiello D, Di Donna L, Prendushi H, Sindona G (2007) Exploitation of endogenous protease activity in raw mastitic milk by MALDI-TOF/TOF. Anal Chem 79:5941–5948Google Scholar
  173. Neviani EM, Tarelli GT, Divizia R (1996) Lysozyme resistance of lactic acid bacteria. Latte 3:90–91Google Scholar
  174. Nudda A, Feligini M, Battacone G, Macciota NPP, Pulina G (2003) Effects of lactation stage, parity, β-lactoglobulin genotype and milk SCC on whey protein composition in Sarda dairy ewes. Ital J Anim Sci 2:29–39Google Scholar
  175. O’Brien B, Meaney WJ, McDonagh D, Kelly A (2001) Influence of somatic cell count and storage interval on composition and processing characteristics of milk from cows in late lactation. Aust J Dairy Technol 56:213–218Google Scholar
  176. O’Driscoll BM, Rattray FP, McSweeney PLH, Kelly AL (1999) Protease activities in raw milk determined using a synthetic heptapeptide substrate. J Food Sci 64:606–611Google Scholar
  177. O’Farell P, Sheenan JJ, Wilkinson MG, Harrington D, Kelly AL (2002) Influence of addition of plasmin or mastitic milk to cheese milk on quality of smear-ripened cheese. Lait 82:305–316Google Scholar
  178. Ogola H, Shitandi A, Nanua J (2007) Effect of mastitis on raw milk compositional quality. J Vet Sci 8:237–242Google Scholar
  179. Ohtsuka H, Kudo K, Mori K, Nagai F, Hatsugaya A, Tajima M, Tamura K, Hoshi F, Koiwa M, Kawamura S (2001) Acute phase response in naturally occurring coliform mastitis. J Vet Med Sci 63:675–678Google Scholar
  180. Oliveira CAF, Fernandes AM, Neto OCC, Fonseca LFL, Silva EOT, Balian SC (2002) Composition and sensory evaluation of whole yogurt produced from milk with different somatic cell counts. Aust J Dairy Technol 57:192–196Google Scholar
  181. Ollivier-Bousquet M (1998) Transferrin and prolactin transcytosis in the lactating mammary epithelial cell. J Mammary Gland Biol Neoplasia 3:303–313Google Scholar
  182. Opdenakker G, van den Steen PE, van Damme J (2001) Gelatinase B: a tuner and amplifier of immune functions. Trends Immunol 22:571–579Google Scholar
  183. Ostdal H, Bjerrum MJ, Pedersen JA, Andersen HJ (2000) Lactoperoxidase-induced protein oxidation in milk. J Agric Food Chem 48:3939–3944Google Scholar
  184. Ostergaard S, Grohn YT (1999) Effects of diseases on test day milk yield and body weight of dairy cows from Danish research herds. J Dairy Sci 82:1188–1201Google Scholar
  185. Othmane MH, Carriedo JA, De la Fuente LF, San Primitivio F (2002) Factors affecting test-day milk composition in dairy ewes, and relationships amongst various milk components. J Dairy Res 69:53–62Google Scholar
  186. Ottogalli GA, Galli LL, Camaschella P (1983) Effect of lysozyme hydrochloride (Afilact) on lactic acid bacteria in whey starters for Grana cheese. Ind Latte 1983:43–48Google Scholar
  187. Ozer B, Grandison A, Robinson R, Atamer M (2003) Effects of lactoperoxidase and hydrogen peroxide on rheological properties of yoghurt. J Dairy Res 70:227–232Google Scholar
  188. Pancholi V, Fischetti VA (1998) α-enolase, a novel strong plasmin(ogen) binding protein on the surface of pathogenic streptococci. J Biol Chem 273:14503–14515Google Scholar
  189. Pasquini LU, Greppi GF, Ballou RD, Bremel RD (1996) Detection of proteolytic degradation of milk proteins and relationship with different levels of SCC in Italian goats. In: The International Symposium on Somatic Cells and Milk of Small Ruminants, Bella, Italy, 25-9-1996, pp 275–281Google Scholar
  190. Pasquini S, Peralta S, Missiaglia E, Carta L, Lemoine NR (2002) Prime-boost vaccines encoding an intracellular idiotype/GM-CSF fusion protein induce protective cell-mediated immunity in murine pre-B cell leukemia. Gene Ther 9:503–510Google Scholar
  191. Pellegrini O, Remeuf F, Rivemale M, Barillet F (1997) Renneting properties of milk from individual ewes: influence of genetic and non-genetic variables, and relationship with physicochemical characteristics. J Dairy Res 64:355–366Google Scholar
  192. Pirisi A, Piredda G, Podda F, Pintus S (1996) Effect of somatic cell count on sheep milk composition and cheese-making properties. Somat Cells Milk Small Rumin 245–251Google Scholar
  193. Pirisi A, Piredda G, Corona M, Pes M, Pintus S, Ledda A (2000) Influence of somatic cell count on ewe’s milk composition, cheese yield and cheese quality. In: Proceedings of 6th Great lakes Dairy Sheep Symposium, Guelph, Canada, pp 47–59Google Scholar
  194. Pisoni G, Fusi E, Cheli F, Rebucci R, Moroni P, Balci A (2004a) Changes in milk composition in dairy goast as affected by subclinical infection with Staphylococcus aureus. In: Book of abstracts of The 8th International Conference on Goats, South Africa, 4-7-2004, p 63Google Scholar
  195. Pisoni G, Fusi E, Cheli F, Rebucci R, Moroni P, Baldi A (2004b) Mammary gland health status and plasmin–plasminogen systemin dairy goat. In: Book of Abstracts of the 8th InternationalConference on Goats, South Africa, 4-7-2004, p 90Google Scholar
  196. Pizzillo M, Cogliandro E, Rubino R, Fedele V (1996) Relationship between somatic cells and milk quality in different goat production systems. In: Proceedings of the International Symposium on Somatic Cells and Milk of Small Ruminants, Bella, Italy, 25-9-1996, pp 269–273Google Scholar
  197. Politis I, Ng-Kwai-Hang KF (1988a) Association between somatic cell count of milk and cheese yielding capacity. J Dairy Sci 71:1720–1727Google Scholar
  198. Politis I, Ng-Kwai-Hang KF (1988b) Effects of somatic cell count on milk composition and cheese making efficiency. J Dairy Sci 71:1711–1719Google Scholar
  199. Politis I, Hang KFNK, Giroux RN (1989a) Environmental-factors affecting plasmin activity in milk. J Dairy Sci 72:1713–1718Google Scholar
  200. Politis I, Lachance E, Block E, Turner JD (1989b) Plasmin and plasminogen in bovine milk: a relationship with involution? J Dairy Sci 72:900–906Google Scholar
  201. Politis I, Zhao X, McBride BW, Burton JH, Turner JD (1991) Plasminogen activator production by bovine milk macrophages and blood monocytes. Am J Vet Res 52:1208–1213Google Scholar
  202. Poutrel B, Caffin JP, Rainard P (1983) Physiological and pathological factors influencing bovine serum albumin content of milk. J Dairy Sci 66:535–541Google Scholar
  203. Prin-Mathieu C, Le Roux Y, Faure GC, Laurent F, Bene MC, Moussaoui F (2002) Enzymatic activities of bovine peripheral blood leukocytes and milk polymorphonuclear neutrophils during intramammary inflammation caused by lipopolysaccharide. Clin Diagn Lab Immunol 9:812–817Google Scholar
  204. Pyörälä S (2003) Indicators of inflammation in the diagnosis of mastitis. Vet Res 34:565–578Google Scholar
  205. Rainard P, Caffin JP (1983) Sequential-changes in serum-albumin, immunoglobulin (Igg1, Igg2, Igm) and lactoferrin concentrations in milk following infusion of Escherichia coli into the udder of immunized and unimmunized cows. Ann Rech Vét 14:271–279Google Scholar
  206. Rainard P, Riollet C (2006) Innate immunity of the bovine mammary gland. Vet Res 37:369–400Google Scholar
  207. Rainard P, Poutrel B, Caffin JP (1982) Lactoferrin and transferrin in bovine milk in relation to certain physiological and pathological factors. Ann Rech Vét 13:321–328Google Scholar
  208. Rajala-Schultz PJ, Grohn YT, McCulloch CE, Guard CL (1999) Effects of clinical mastitis on milk yield in dairy cows. J Dairy Sci 82:1213–1220Google Scholar
  209. Rambeaud M, Almeida RA, Pighetti GM, Oliver SP (2003) Dynamics of leukocytes and cytokines during experimentally induced Streptococcus uberis mastitis. Vet Immunol Immunopathol 96:193–205Google Scholar
  210. Randolph HE, Erwin RE (1974) Influence of mastitis on properties of milk. X. Fatty acid composition. J Dairy Sci 57:865–868Google Scholar
  211. Raulo SM, Sorsa T, Tervahartiala T, Latvanen T, Pirila E, Hirvonen J, Maisi P (2002) Increase in milk metalloproteinase activity and vascular permeability in bovine endotoxin-induced and naturally occurring Escherichia coli mastitis. Vet Immunol Immunopathol 85:137–145Google Scholar
  212. Raynal-Ljutovac K, Gaborit P, Lauret A (2005) The relationship between quality criteria of goat milk, its technological properties and the quality of the final products. Small Rumin Res 60:167–177Google Scholar
  213. Raynal-Ljutovac K, Pirisi A, De Cremoux R, Gonzalo C (2007) Somatic cells of goat and sheep milk: analytical, sanitary, productive and technological aspects. Small Rumin Res 68:126–144Google Scholar
  214. Reed SB, Wesson CA, Liou LE, Trumble WR, Schlievert PM, Bohach GA, Bayles KW (2001) Molecular characterization of a novel Staphylococcus aureus serine protease operon. Infect Immun 69:1521–1527Google Scholar
  215. Rejman JJ, Turner JD, Oliver SP (1993) Influence of recombinant bovine cytokines on proliferation of a bovine mammary epithelial cell line. Cell Biol Int 17:619–621Google Scholar
  216. Revilla I, Rodriguez-Nogales JM, Vivar-Quintana AM (2007) Proteolysis and texture of hard ewes’ milk cheese during ripening as affected by somatic cell counts. J Dairy Res 74:127–136Google Scholar
  217. Revilla I, Rodriguez-Nogales JM, Vivar-Quintana AM (2009) Effect of somatic cell counts on ewes’ milk protein profile and cheese-making properties in different sheep breeds reared in Spain. J Dairy Res 76:210–215Google Scholar
  218. Riollet C, Rainard P, Poutrel B (2000) Differential induction of complement fragment C5a and inflammatory cytokines during intramammary infections with Escherichia coli and Staphylococcus aureus. Clin Diagn Lab Immunol 7:161–167Google Scholar
  219. Rogers SA, Mitchell GE (1994) The relationship between somatic-cell count, composition and manufacturing properties of bulk milk: cheddar cheese and skim-milk yogurt. Aust J Dairy Technol 49:70–74Google Scholar
  220. Rogers SA, Mitchell GE, Bartley JP (1989a) The relationship between somatic cell count, composition and manufacturing properties of bulk milk. 4. Non-protein constituents. Aust J Dairy Technol 44:53–56Google Scholar
  221. Rogers SA, Slattery SL, Mitchell GE, Hirst PA, Grieve PA (1989b) The relationship between somatic cell count, composition and manufacturing properties of bulk milk. 3.Individual proteins. Aust J Dairy Technol 44:49–52Google Scholar
  222. Romero G, Sendra E, Muelas R, az-Sanchez JR (2010) Effect of electrical conductivity of goat’s milk on characteristics of fresh cheese. Milchwissenschaft 65:56–59Google Scholar
  223. Rosey EL, Lincoln RA, Ward PN, Yancey RJ, Leigh JA (1999) PauA: a novel plasminogen activator from Streptococcus uberis (vol 178, pg 27, 1999). FEMS Microbiol Lett 180:353Google Scholar
  224. Rouseff RL (1990) Bitterness in food products: an overview. In: Rousseff RL (ed) Bitterness in foods and beverages. Elsevier, Amsterdam, pp 1–14Google Scholar
  225. Saeman AI, Verdi RJ, Galton DM, Barbano DM (1988) Effect of mastitis on proteolytic activity in bovine-milk. J Dairy Sci 71:505–512Google Scholar
  226. Salih AM, Anderson M (1979) Observations on the influence of high cell count on lipolysis in bovine milk. J Dairy Res 46:453–462Google Scholar
  227. Salih MA, Sandine WE (1980) Lactic streptococcal agglutinins: a review. J Food Prot 43:856Google Scholar
  228. Salih MA, Sandine WE (1984) Rapid test for detecting lactic streptococcal agglutinins in cheese milk. J Dairy Sci 67:7–23Google Scholar
  229. Sanchez L, Lujan L, Oria R, Castillo H, Perez D, Ena JM, Calvo M (1992) Synthesis of lactoferrin and transport of transferrin in the lactating mammary-gland of sheep. J Dairy Sci 75:1257–1262Google Scholar
  230. Santos MV, Ma Y, Barbano DM (2003) Effect of somatic cell count on proteolysis and lipolysis in pasteurized fluid milk during shelf-life storage. J Dairy Sci 86:2491–2503Google Scholar
  231. Santos JE, Cerri RL, Ballou MA, Higginbotham GE, Kirk JH (2004) Effect of timing of first clinical mastitis occurrence on lactational and reproductive performance of Holstein dairy cows. Anim Reprod Sci 80:31–45Google Scholar
  232. Schalm OW, Carroll EJ, Jain NC (1971) Bovine mastitis. Lea &Febiger, PhiladelphiaGoogle Scholar
  233. Schanbacher FL, Smith KL (1975) Formation and role of unusual whey proteins and enzymes: relation to mammary function. J Dairy Sci 58:1048–1062Google Scholar
  234. Scharfen EC, Mills DA, Maga EA (2007) Use of human lysozyme transgenic goat milk in cheese making: effects on lactic acid bacteria performance. J Dairy Sci 90:4084–4091Google Scholar
  235. Schmedt Auf Der Gunne H, Tenhagen BA, Kutzer P, Forderung D, Heuwieser W (2002) Do lactoferrin, lysozyme and the lactoperoxidase-thiocyanate-hydrogen peroxide-system cause negative microbiological results in mastitis secretions? Dtsch Tierarztl Wochenschr 109:300–305Google Scholar
  236. Schmitz S, Pfaffl MW, Meyer HH, Bruckmaier RM (2004) Short-term changes of mRNA expression of various inflammatory factors and milk proteins in mammary tissue during LPS-induced mastitis. Domest Anim Endocrinol 26:111–126Google Scholar
  237. Schott G (1967) Is yogurt manufacture affected by milk from mastitic cows? Dairy Sci Abstr 29:408Google Scholar
  238. Schukken YH, Hertl J, Bar D, Bennett GJ, Gonzalez RN, Rauch BJ, Santisteban C, Schulte HF, Tauer L, Welcome FL, Grohn YT (2009) Effects of repeated gram-positive and gram-negative clinical mastitis episodes on milk yield loss in Holstein dairy cows. J Dairy Sci 92:3091–3105Google Scholar
  239. Seifu E, Buys EM, Donkin EF (2003) Effect of the lactoperoxidase system on the activity of mesophilic cheese starter cultures in goat milk. Int Dairy J 13:953–959Google Scholar
  240. Seifu E, Buys EM, Donkin EF (2005) Significance of the lactoperoxidase system in the dairy industry and its potential applications: a review. Trends Food Sci Technol 16:137–154Google Scholar
  241. Sharma KK, Randolph HE (1974) Influence of mastitis on properties of milk. 8. Distribution of soluble and micellar casein. J Dairy Sci 57:19–23Google Scholar
  242. Sheffield LG (1997) Mastitis increases growth factor messenger ribonucleic acid in bovine mammary glands. J Dairy Sci 80:2020–2024Google Scholar
  243. Shipe WF, Senyk GF (1981) Effects of processing conditions on lipolysis in milk. J Dairy Sci 64:2146–2149Google Scholar
  244. Shuster DE, Kehrli ME, Baumrucker CR (1995) Relationship of inflammatory cytokines, growth-hormone, and insulin-like growth-factor-I to reduced performance during infectious-disease. Proc Soc Exp Biol Med 210:140–149Google Scholar
  245. Shuster DE, Lee EK, Kehrli ME Jr (1996) Bacterial growth, inflammatory cytokine production, and neutrophil recruitment during coliform mastitis in cows within ten days after calving, compared with cows at midlactation. Am J Vet Res 57:1569–1575Google Scholar
  246. Shuster DE, Kehrli ME, Rainard P, Paape M (1997) Complement fragment C5a and inflammatory cytokines in neutrophil recruitment during intramammary infection with Escherichia coli. Infect Immun 65:3286–3292Google Scholar
  247. Singh LN, Ganguli NC (1975) Alterations in the micellar, soluble and other casein fractions in the Serum abnormal bovine milk secretions. Ind J Dairy Sci 28:151–158Google Scholar
  248. Singh K, Dobson J, Phyn C, Davis S, Farr V, Molenaar A (2006) Streptococcus uberis increases apoptosis of bovine mammary epithelial cells (MEC) and decreases integrin and focal adhesion kinase (FAK) mRNA expression. J Anim Sci 84:148Google Scholar
  249. Somers JM, O’Brien B, Meaney WJ, Kelly AL (2003) Heterogeneity of proteolytic enzyme activities in milk samples of different somatic cell count. J Dairy Res 70:45–50Google Scholar
  250. Sordillo LM, Nickerson SC, Akers RM (1989) Pathology of Staphylococcus aureus mastitis during lactogenesis: relationships with bovine mammary structure and function. J Dairy Sci 72:228–240Google Scholar
  251. Suzuki J, Katoh N (1990) Cysteine protease in bovine milk capable of hydrolyzing casein as the substrate and elevation of the activity during the course of mastitis. Jpn J Vet Sci 52:947–954Google Scholar
  252. Swanson KM, Stelwagen K, Dobson J, Henderson HV, Davis SR, Farr VC, Singh K (2009) Transcriptome profiling of Streptococcus uberis-induced mastitis reveals fundamental differences between immune gene expression in the mammary gland and in a primary cell culture model. J Dairy Sci 92:117–129Google Scholar
  253. Tallamy PT, Randolph HE (1970) Influence of mastitis on properties of milk. V. Total and free concentrations of major minerals in skimmilk. J Dairy Sci 53:1386–1388Google Scholar
  254. Tao WJ, Mallard B (2007) Differentially expressed genes associated with Staphylococcus aureus mastitis of Canadian Holstein cows. Vet Immunol Immunopathol 120:201–211Google Scholar
  255. Urech E, Puhan Z, Schallibaum M (1999) Changes in milk protein fraction as affected by subclinical mastitis. J Dairy Sci 82:2402–2411Google Scholar
  256. Vangroenweghe F, Rainard P, Paape M, Duchateau L, Burvenich C (2004) Increase of Escherichia coli inoculum doses induces faster innate immune response in primiparous cows. J Dairy Sci 87:4132–4144Google Scholar
  257. Vangroenweghe F, Duchateau L, Boutet P, Lekeux P, Rainard P, Paape MJ, Burvenich C (2005) Effect of carprofen treatment following experimentally induced Escherichia coli mastitis in primiparous cows. J Dairy Sci 88:2361–2376Google Scholar
  258. Vanselow J, Yang W, Herrmann J, Zerbe H, Schuberth HJ, Petzl W, Tomek W, Seyfert HM (2006) DNA-remethylation around a STAT5-binding enhancer in the α S1-casein promoter is associated with abrupt shutdown of α S1-casein synthesis during acute mastitis. J Mol Endocrinol 37:463–477Google Scholar
  259. Vautor E, Cockfield J, Le Marechal C, Le Loir Y, Chevalier M, Robinson DA, Thiery R, Lindsay J (2009) Difference in virulence between Staphylococcus aureus isolates causing gangrenous mastitis versus subclinical mastitis in a dairy sheep flock. Vet Res 40:56–67Google Scholar
  260. Verdi RJ, Barbano DM (1991) Effect of coagulants, somatic-cell enzymes, and extracellular bacterial enzymes on plasminogen activation. J Dairy Sci 74:772–782Google Scholar
  261. Verdi RJ, Barbano DM, Dellavalle ME, Senyk GF (1987) Variability in true protein, casein, nonprotein nitrogen, and proteolysis in high and low somatic cell milks. J Dairy Sci 70:230–242Google Scholar
  262. Vianna PCB, Mazal G, Santos MV, Bolini HMA, Gigante ML (2008) Microbial and sensory changes throughout the ripening of Prato cheese made from milk with different levels of somatic cells. J Dairy Sci 91:1743–1750Google Scholar
  263. Viguier C, Arora S, Gilmartin N, Welbeck K, O’Kennedy R (2009) Mastitis detection: current trends and future perspectives. Trends Biotechnol 27:486–493Google Scholar
  264. Vivar-Quintana AM, De la Mano EB, Revilla I (2006) Relationship between somatic cell counts and the properties of yoghurt made from ewes’ milk. Int Dairy J 16:262–267Google Scholar
  265. Waes G, Belleghem VM (1969) Influence de la mammite sur les propiétés technologiques et sur la qualité des produits laitiers. Lait 49:266–290Google Scholar
  266. Watanabe A, Yagi Y, Shiono H, Yokomizo Y (2000) Effect of intramammary infusion of tumour necrosis factor-alpha on milk protein composition and induction of acute-phase protein in the lactating cow. J Vet Med B Infect Dis Vet Public Health 47:653–662Google Scholar
  267. Watanabe A, Yagi Y, Shiono H, Yokomizo Y, Inumaru S (2008) Effects of intramammary infusions of interleukin-8 on milk protein composition and induction of acute-phase protein in cows during mammary involution. Can J Vet Res 72:291–296Google Scholar
  268. Weaver JC, Kroger M (1977) Protein, casein, and noncasein protein percentages in milk with high somatic cell counts. J Dairy Sci 60:878–881Google Scholar
  269. Wedholm A, Moller HS, Lindmark-Mansson H, Rasmussen MD, Andren A, Larsen LB (2008) Identification of peptides in milk as a result of proteolysis at different levels of somatic cell counts using LC MALDI MS/MS detection. J Dairy Res 75:76–83Google Scholar
  270. Wegner TN, Stull JW (1978) Relation between mastitis test score, mineral composition of milk, and blood electrolyte profiles in Holstein cows. J Dairy Sci 61:1755–1759Google Scholar
  271. Weinrauch Y, Zychlinsky A (1999) The induction of apoptosis by bacterial pathogens. Annu Rev Microbiol 53:155–187Google Scholar
  272. Wickstrom E, Persson-Waller K, Lindmark-Mansson H, Ostensson K, Sternesjo A (2009) Relationship between somatic cell count, polymorphonuclear leucocyte count and quality parameters in bovine bulk tank milk. J Dairy Res 76:195–201Google Scholar
  273. Wilson DJ, Gonzalez RN, Hertl J, Schulte HF, Bennett GJ, Schukken YH, Grohn YT (2004) Effect of clinical mastitis on the lactation curve: a mixed model estimation using daily milk weights. J Dairy Sci 87:2073–2084Google Scholar
  274. Winter P, Schilcher F, Fuchs K, Colditz IG (2003) Dynamics of experimentally induced Staphylococcus epidermidis mastitis in East Friesian milk ewes. J Dairy Res 70:157–164Google Scholar
  275. Ying CW, Wang HT, Hsu JT (2002) Relationship of somatic cell count, physical, chemical and enzymatic properties to the bacterial standard plate count in dairy goat milk. Livest Prod Sci 74:63–77Google Scholar
  276. Zavizion B, White JH, Bramley AJ (1997) Staphylococcus aureus stimulates urokinase-type plasminogen activator expression by bovine mammary cells. J Infect Dis 176:1637–1640Google Scholar
  277. Zeng SS, Escobar EN (1996) Factors affecting somatic cell count of goat milk throughout lactation: parity and milk production, in: The International Symposium on Somatic Cells and Milk of Small Ruminants, Bella, Italy, 25-9-1996, pp 157–160Google Scholar
  278. Zhang S, Maddox CW (2000) Cytotoxic activity of coagulase-negative staphylococci in bovine mastitis. Infect Immun 68:1102–1108Google Scholar
  279. Zhao X, Lacasse P (2008) Mammary tissue damage during bovine mastitis: causes and control. J Anim Sci 86:57–65Google Scholar

Copyright information

© INRA and Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Caroline Le Maréchal
    • 1
    • 2
    • 3
  • Richard Thiéry
    • 3
  • Eric Vautor
    • 4
  • Yves Le Loir
    • 1
    • 2
  1. 1.INRA, UMR1253 STLORennesFrance
  2. 2.Agrocampus Ouest, UMR1253 STLORennesFrance
  3. 3.ANSES, Laboratoire d’études et de recherches des ruminantsSophia-AntipolisFrance
  4. 4.Sophia-AntipolisFrance

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