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Saffron (Crocus sativus L.): gold of the spices—a comprehensive review

Horticulture, Environment, and Biotechnology volume 62, pages 661–677 (2021)Cite this article

Abstract

Saffron (Crocus sativus L.) is a monocotyledonous herbaceous triploid plant that produces the most expensive spice in the world. Its main constituents, crocin, picrocrocin, and safranal, are responsible for color, taste, and aroma, respectively. The saffron plant produces a red-colored spice that is important in pharmaceutics, cosmetics, perfumery, and textile dye-producing industries. Iran produces almost 90% of the total world production. The saffron market is expected to grow by 12.09% in the forecast period 2020 to 2027. This paper reviews the current knowledge about the taxonomy, geographical distribution, reproductive biology, chemical composition, therapeutic and traditional uses, and agro-technology of the world’s most expensive spice crop, saffron.

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References

  • Abdullaev FI, Frenkel GD (1992) Effect of saffron on cell colony formation and cellular nucleic acid and protein synthesis. BioFactors 3(3):201–204

    CAS  PubMed  Google Scholar 

  • Acar B, Sadikoglu H, Ozkaymak M (2011) Freeze drying of saffron (Crocus sativus L.). Dry Technol 29:1622–1627. https://doi.org/10.1080/07373937.2011.590263

    Article  CAS  Google Scholar 

  • Akhondzadeh S, Shafiee Sabet M, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SS, Yousefi MH, Alimardani R, Jamshidi A, Rezazadeh SA, Yousefi A, Zare F, Moradi A, Vossoughi A (2010) A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease. Psychopharmacology 207:637–643. https://doi.org/10.1007/s00213-009-1706-1

    Article  CAS  PubMed  Google Scholar 

  • Ali A, Hakim IA (2017) An overview of the production practices and trade mechanism of saffron in Kashmir Valley (India): issues and challenges. Pac Bus Rev Int 10:97–106

    CAS  Google Scholar 

  • Alidadi H, Saffari AR, Peiravi R (2013) Effects of biofertilizers effects of compost, vermicompost and sulfur compost on yield of saffron. World Appl Sci J 21:1386–1390

    CAS  Google Scholar 

  • Alonso GL, Salinas MR, Garijo J, Sanchez-Fernandez MA (2001) Composition of crocin and picrocrocin from Spanish saffron (Crocus sativus L.). J Food Qual 24:219–233

    Article  CAS  Google Scholar 

  • Alonso GL, Zalacain A, Carmona M (2012) Saffron. In: Peter KV (ed) Handbook of herbs and spices, vol 1, 2nd edn. Woodhead Publishing, Cambridge, pp 469–498. https://doi.org/10.1533/9780857095671.469

    Chapter  Google Scholar 

  • Andabjadid SS, Eslam BP, Bakhtavari ARS, Mohammadi H (2015) Effects of corm size and plant density on saffron (Crocus sativus L.) yield and its components. Int J Agron Agril Res 6:20–26

    Google Scholar 

  • Anonymous (2019) https://www.tpci.in/blogs/product-profile-saffron/. Accessed 19 Jan 2020

  • Assimopoulou AN, Sinakos Z, Papageorgiou VP (2005) Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phyther Res 19:997–1000. https://doi.org/10.1002/ptr.1749

    Article  CAS  Google Scholar 

  • Aung HH, Wang CZ, Ni M, Fishbein A, Mehendale SR, Xie JT, Shoyama CY, Yuan CS (2007) Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells. Exp Oncol 29:175–180

    CAS  PubMed  PubMed Central  Google Scholar 

  • Aytekin A, Acikgoz AO (2008) Hormone and microorganism treatments in the cultivation of saffron (Crocus Sativus L.) plants. Molecules 13:1135–1147. https://doi.org/10.3390/molecules13051135

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Babaei S, Talebi M, Bahar M (2014) Developing an SCAR and ITS reliable multiplex PCR-based assay forsafflower adulterant detection in saffron samples. Food Control 35:323–328. https://doi.org/10.1016/j.foodcont.2013.07.019

    Article  CAS  Google Scholar 

  • Badie Bostan H, Mehri S, Hosseinzadeh H (2017) Toxicology effects of saffron and its constituents: a review. Iran J Basic Med Sci 20:110–121. https://doi.org/10.22038/ijbms.2017.8230

    Article  Google Scholar 

  • Bathaie SZ, Farajzade A, Hoshyar R (2014) A review of the chemistry and uses of crocins and crocetin, the carotenoid natural dyes in saffron, with particular emphasis on applications as colorants including their use as biological stains. Biotech Histochem 89:401–411. https://doi.org/10.3109/10520295.2014.890741

    Article  CAS  PubMed  Google Scholar 

  • Bayat M, Rahimi M, Ramezani M (2016) Determining the most effective traits to improve saffron (Crocus sativus L.) yield. Physiol Mol Biol Plants 22:153–161. https://doi.org/10.1007/s12298-016-0347-1

    Article  PubMed  PubMed Central  Google Scholar 

  • Behnia MR (2008) Effect of planting methods and corm density in saffron (Crocus sativus L.) yield in Damavand region. Pajouhesh-Va-Sazandegi 21:101–108

    Google Scholar 

  • Bhandari PR (2015) Crocus sativus L. (saffron) for cancer chemoprevention: a mini review. J Tradit Complement Med 5:81–87. https://doi.org/10.1016/j.jtcme.2014.10.009

    Article  PubMed  PubMed Central  Google Scholar 

  • Cagliani LR, Culeddu N, Chessa M, Consonni R (2015) NMR investigations for a quality assessment of Italian PDO saffron (Crocus sativus L.). Food Control 50:342–348. https://doi.org/10.1016/j.foodcont.2014.09.017

    Article  CAS  Google Scholar 

  • Caiola MG (2004) Saffron reproductive biology. Acta Hortic 650:25–37

    Article  Google Scholar 

  • Cardone L, Castronuovo D, Perniola M, Cicco N, Candido V (2020) Saffron (Crocus sativus L.), the king of spices: an overview. Sci Hortic 272:109560

    Article  CAS  Google Scholar 

  • Carmona M, Zalacain A, Sánchez AM, Novella JL, Alonso GL (2006) Crocetin esters, picrocrocin and its related compounds present in Crocus sativus stigmas and Gardenia jasminoides fruits. Tentative identification of seven new compounds by LC-ESI-MS. J Agric Food Chem 54:973–979. https://doi.org/10.1021/jf052297w

    Article  CAS  PubMed  Google Scholar 

  • Cavusoglu A (2010) The effects of cold storage of saffron (Crocus sativus L.) corms on morphology, stigma and corm yield. Afr J Agric Res 5:1812–1820

    Google Scholar 

  • Chaouqi S, Moratalla-Lopez N, Lage M, Lorenzo C, Alonso GL, Guedira T (2018) Effect of drying and storage process on Moroccan saffron quality. Food Biosci 22:146–153. https://doi.org/10.1016/j.fbio.2018.02.003

    Article  CAS  Google Scholar 

  • Chen Y, Zhang H, Tian X, Zhao C, Cai L, Liu Y et al (2008) Antioxidant potential of crocins and ethanol extracts of Gardenia jasminoides ELLIS and Crocus sativus L.: A relationship investigation between antioxidant activity and crocin contents. Food Chem. 109(3):484–492

    Article  CAS  Google Scholar 

  • Chen D, Xing B, Yi H, Li Y, Zheng B, Wang Y, Shao Q (2020) Effects of different drying methods on appearance, microstructure, bioactive compounds and aroma compounds of saffron (Crocus sativus L.). LWT 120:1–7. https://doi.org/10.1016/j.lwt.2019.108913

    Article  CAS  Google Scholar 

  • Cheng J, Jingjia S, Yuan W, Xiaodong H (2015) One kind of saffron shower gel and preparation method. China patent CN103263373B

  • Cirujeda A, Marí AI, Aibar J, Fenandez-Cavada S, Pardo G, Zaragoza C (2014) Experiments on mechanical weed control in saffron crops in Spain. J Plant Dis Prot 121:223–228. https://doi.org/10.1007/BF03356515

    Article  Google Scholar 

  • Dar MH, Groach R, Razvi SM, Singh N (2017) Saffron crop (golden crop) in modern sustainable agricultural system. Int J Res Appl Sci Eng Technol 5:247–259

    Article  Google Scholar 

  • Dastranj M, Sepaskhah AR (2019) Saffron response to irrigation regime, salinity and planting method. Sci Hortic 251:215–224

    Article  Google Scholar 

  • De Juan JA, Córcoles HL, Muñoz RM, Picornell MR (2009) Yield and yield components of saffron under different cropping systems. Ind Crops Prod 30(2):212–219

    Article  CAS  Google Scholar 

  • De Mesa NA, Munoz-Mingarro D, Pons EMB (2016) Biowaste saffron extracts as active ingredients of cosmetic products antioxidants. Spain patent ES2646415B1

  • Dhar AK, Mir GM (1997) Saffron in Kashmir-VI: a review of distribution and production. J Herbs Spices Med Plants 4:83–90. https://doi.org/10.1300/J044v04n04_09

    Article  Google Scholar 

  • Douglas MH, Smallfield BM, Wallace AR, McGimpsey JA (2014) Saffron (Crocus sativus L.): The effect of mother corm size on progeny multiplication, flower and stigma production. Sci Hortic 166:50–58

    Article  Google Scholar 

  • Emadi B (2009) Separating saffron flower parts using vertical air column. World Acad Sci Eng Technol 37:25–28

    Google Scholar 

  • Escribano J, Alonso GL, Coca-Prados M, Fernandez JA (1996) Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett 100:23–30. https://doi.org/10.1016/0304-3835(95)04067-6

    Article  CAS  PubMed  Google Scholar 

  • Falong L (2018) Treating method for corm of saffron. China patent CN108112296A

  • Feili HR, Aghaee EM, Taslimi A (2012) Study of chemical and microbiological properties of saffron dehydrated by using solar drying system. Int J Renew Energy Res 2:627–630. https://doi.org/10.20508/ijrer.89939

    Article  Google Scholar 

  • Fornasier VL, Protzner K, Zhang I, Mason L (1996) The prognostic significance of histomorphometry and immunohistochemistry in giant cell tumors of bone. Hum pathol 27(8):754–760

    Article  CAS  PubMed  Google Scholar 

  • Ganie MA, Nusrath A (2016) Marketing and trade mechanism of saffron (Crocus sativus) 7:55–62. https://doi.org/10.9790/5933-0705045562

  • Ghorbani R, Koocheki A (2017) Sustainable cultivation of saffron in Iran. In: Lichtfouse E (ed) Sustainable agriculture reviews, vol 25. Springer, Cham, pp 169–203

    Chapter  Google Scholar 

  • Golmohammadi F (2014) Saffron and its farming, economic importance, export, medicinal characteristics and various uses in South Khorasan Province-East of Iran. Int J Farm Allied Sci 3:566–596

    Google Scholar 

  • Gregory MJ, Menary RC, Davies NW (2005) Effect of drying temperature and air flow on the production and retention of secondary metabolites in saffron. J Agric Food Chem 53:5969–5975. https://doi.org/10.1021/jf047989j

    Article  CAS  PubMed  Google Scholar 

  • Gresta F, Lombardo GM, Siracusa L, Ruberto G (2008) Saffron, an alternative crop for sustainable agricultural systems. A review. Agron Sustain Dev 28:95–112. https://doi.org/10.1051/agro:2007030

    Article  CAS  Google Scholar 

  • Gresta F, Santonoceto C, Avola G (2016) Crop rotation as an effective strategy for saffron (Crocus sativus L.) cultivation. Sci Hortic (amst) 211:34–39. https://doi.org/10.1016/j.scienta.2016.08.007

    Article  Google Scholar 

  • Hajyzadeh M, Asil H, Yildirim MU, Sarihan EO, Ayanoglu F, Khawar KM (2017) Evaluating effects of corm circumference and storage temperatures on yield and yield components of saffron at different elevations. Acta Hortic 1184:39–46. https://doi.org/10.17660/ActaHortic.2017.1184.6

    Article  Google Scholar 

  • Hamid N, Kachroo J, Bhat A, Peer QJ (2017) An economic analysis of marketing and price spread of saffron in J&K State. J Pharmacogn Phytochem 6:1231–1239

    Google Scholar 

  • Heidarbeigi K, Mohtasebi SS, Foroughirad A, Ghasemi-Varnamkhasti M, Rafiee S, Rezaei K (2015) Detection of adulteration in saffron samples using electronic nose. Int J Food Prop 18:1391–1401. https://doi.org/10.1080/10942912.2014.915850

    Article  CAS  Google Scholar 

  • Hosseini A, Razavi BM, Hosseinzadeh H (2018) Saffron (Crocus sativus) petal as a new pharmacological target: a review. Iran J Basic Med Sci 21:1091–1099

    PubMed  PubMed Central  Google Scholar 

  • Hosseinzadeh H, Sadeghnia HR, Ghaeni FA, Motamedshariaty VS, Mohajeri SA (2012) Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats. Phyther Res 26:381–386. https://doi.org/10.1002/ptr.3566

    Article  CAS  Google Scholar 

  • Humphries J (1996) The essential saffron companion. Ten Speed Press, Berkeley, p 20

    Google Scholar 

  • Humphries J (1998) The essential saffron companion. Ten Speed Press

  • Husaini AM, Hassan B, Ghani MY, Teixeira da Silva JA, Kirmani NA (2010) Saffron (Crocus sativus Kashmirianus) cultivation in Kashmir: practices and problems. Funct Plant Sci Biotechnol 4:108–115

    Google Scholar 

  • Jami N, Rahimi A, Naghizadeh M, Sedaghati E (2020) Investigating the use of different levels of Mycorrhiza and Vermicompost on quantitative and qualitative yield of saffron (Crocus sativus L.). Sci Hortic (amst) 262:109027. https://doi.org/10.1016/j.scienta.2019.109027

    Article  CAS  Google Scholar 

  • Jan S, Wani AA, Kamili AN, Kashtwari M (2014) Distribution, chemical composition and medicinal importance of saffron (Crocus sativus L.). Afr J Plant Sci 8:537–545

    Google Scholar 

  • Kabiri M, Rezadoost H, Ghassempour A (2017) A comparative quality study of saffron constituents through HPLC and HPTLC methods followed by isolation of crocins and picrocrocin. LWT 84:1–9

    Article  CAS  Google Scholar 

  • Kafi M, Showket T (2007) A comparative study of saffron agronomy and production systems of Khorasan (Iran) and Kashmir (India). Acta Hortic 739:123–132. https://doi.org/10.17660/ActaHortic.2007.739.16

    Article  Google Scholar 

  • Kafi M, Kamili AN, Husaini AM, Ozturk M, Altay V (2018) An expensive spice saffron (Crocus sativus L.): a case study from Kashmir, Iran, and Turkey. In: Ozturk M, Hakeem K, Ashraf M, Ahmad M (eds) Global perspectives on underutilized crops. Springer, Cham, pp 109–149

    Chapter  Google Scholar 

  • Khan MA, Naseer S, Nagoo S, Nehvi FA (2011) Behaviour of saffron (Crocus sativus L.) corms for daughter corm production. J Phytol 3:47–49

    Google Scholar 

  • Kheirandish M, Gowda MVS (2012) Marketing efficiency and price spread for saffron in Iran. Trends Agric Econ 5:23–30

    Article  Google Scholar 

  • Khoshsang H, Ghaffarinejad A (2018) Rapid removal of lead (II) ions from aqueous solutions by saffron flower waste as a green biosorbent. J Environ Chem Eng 6:6021–6027. https://doi.org/10.1016/j.jece.2018.09.020

    Article  CAS  Google Scholar 

  • Khosravi M, (2005) Agroecological and economic prospects for intercropping cumin with saffron and annual crops. MSc. thesis, Ferdowsi University of Mashhad, Iran

  • Koocheki AA (2003) Indigenous knowledge in agriculture with particular reference to saffron production in Iran. In: International symposium on saffron biology and biotechnology, vol 650, pp 175–182

  • Koocheki A, Alizadeh A, Ganjali A (2010) The effect of increased temperature on flowering behaviour of saffron (Crocus sativus L.). Iran J Food Crop Res 8:324–335. https://www.sid.ir/en/journal/ViewPaper.aspx?ID=220320

  • Koocheki A, Seyyedi SM, Eyni MJ (2014) Irrigation levels and dense planting affect flower yield and phosphorus concentration of saffron corms under semi-arid region of Mashhad. Northeast Iran Sci Hortic (amst) 180:147–155. https://doi.org/10.1016/j.scienta.2014.10.031

    Article  CAS  Google Scholar 

  • Koocheki A, Rezvani MP, Fallahi HR (2016) Effects of planting dates, irrigation management and cover crops on growth and yield of saffron (Crocus sativus L.). Agroecology 8:435–451. https://www.sid.ir/en/Journal/ViewPaper.aspx?ID=545220

  • Kumar ASS (2017) Methods for recombinant production of saffron compounds 1. US patent US20170067063A1

  • Kumar R, Sharma OC (2017) Saffron (Crocus sativus L.) growth and yield as influenced by organic farming practices. J Agric Ecol 4:25–32

    Google Scholar 

  • Kumar R, Singh V, Devi K, Sharma M, Singh MK, Ahuja PS (2009) State of art of saffron (Crocus sativus L.) agronomy: a comprehensive review. Food Rev Int 25(1):44–85. https://doi.org/10.1080/87559120802458503

    Article  Google Scholar 

  • Lage M, Cantrell CL (2009) Quantification of saffron (Crocus sativus L.) metabolites crocins, picrocrocin and safranal for quality determination of the spice grown under different environmental Moroccan conditions. Sci hortic 121(3):366–373

    Article  CAS  Google Scholar 

  • Leone S, Recinella L, Chiavaroli A, Orlando G, Ferrante C, Leporini L, Brunetti L, Menghini L (2018) Phytotherapic use of the Crocus sativus L. (Saffron) and its potential applications: a brief overview. Phyther Res 32:2364–2375. https://doi.org/10.1002/ptr.6181

    Article  CAS  Google Scholar 

  • Levine DS, Surawicz CM, Ajer TN, Dean PJ, Rubin CE (1988) Diffuse excess mucosal collagen in rectal biopsies facilitates differential diagnosis of solitary rectal ulcer syndrome from other inflammatory bowel diseases. Dig dis sci 33(11):1345–1352

    Article  CAS  PubMed  Google Scholar 

  • Maggi L, Carmona M, Zalacain A, Kanakis CD, Anastasaki E, Tarantilis PA, Polissiou MG, Alonso GL (2010) Changes in saffron volatile profile according to its storage time. Food Res Int 43:1329–1334. https://doi.org/10.1016/j.foodres.2010.03.025

    Article  CAS  Google Scholar 

  • Maggi MA, Bisti S, Picco C (2020) Saffron: chemical composition and neuroprotective activity. Molecules 25:1–15

    Article  CAS  Google Scholar 

  • Mahmood P (2017) A composition comprising resveratrol and saffron. United Kingdom patent GB2498660B

  • Melnyk JP, Wang S, Marcone MF (2010) Chemical and biological properties of the world’s most expensive spice: saffron. Food Res Int 43:1981–1989. https://doi.org/10.1016/j.foodres.2010.07.033

    Article  CAS  Google Scholar 

  • Menghini L, Leporini L, Vecchiotti G, Locatelli M, Carradori S, Ferrante C, Zengin G, Recinella L, Chiavaroli A, Leone S, Brunetti L, Orlando G (2018) Crocus sativus L. stigmas and byproducts: qualitative fingerprint, antioxidant potentials and enzyme inhibitory activities. Food Res Int 109:91–98. https://doi.org/10.1016/j.foodres.2018.04.028

    Article  CAS  PubMed  Google Scholar 

  • Menia M, Iqbal S, Zahida R, Tahir S, Rh K, Aa S (2018) Production technology of saffron for enhancing productivity. J Pharmacogn Phytochem 7:1033–1039

    Google Scholar 

  • Milajerdi A, Djafarian K, Hosseini B (2016) The toxicity of saffron (Crocus sativus L.) and its constituents against normal and cancer cells. J Nutr Intermed Metab 3:23–32. https://doi.org/10.1016/j.jnim.2015.12.332

    Article  Google Scholar 

  • Mir MA, Nehvi FA, Agarwal SG (2008) Post harvest processing and value addition. In: Nehvi FA, Wani SA (eds) Saffron Prod. Jammu Kashmir, Dir. Ext. Educ. SKUAST-K, India, pp 242–255

  • Mirsafi ZS, Sepaskhah AR, Ahmadi SH, Kamgar-Haghighi AA (2016) Assessment of AquaCrop model for simulating growth and yield of saffron (Crocus sativus L.). Sci Hortic 211:343–351

    Article  Google Scholar 

  • Mohammad AAA, Rezvani MP, Fallahi J (2011) Effects of planting pattern and the first irrigation date on growth and yield of saffron (Crocus sativus L.). Agroecology 3:83–93

    Google Scholar 

  • Mohammad M, Amiri ME, Sharghi Y (2012) Respond of saffron (Crocus sativus L.) to animal manure application. J Med Plants Res 6:1323–1326

    Article  Google Scholar 

  • Molina RV, Renau-Morata B, Nebauer SG, Garcia-Luis A, Guardiola JL (2010) Greenhouse saffron culture-temperature effects on flower emergence and vegetative growth of the plants. Acta Hortic 850:91–94

    Article  Google Scholar 

  • Montoro P, Maldini M, Luciani L, Tuberoso CIG, Congiu F, Pizza C (2012) Radical scavenging activity and LC-MS metabolic profiling of petals, stamens, and flowers of Crocus sativus L. J Food Sci 77:1–8. https://doi.org/10.1111/j.1750-3841.2012.02803.x

    Article  CAS  Google Scholar 

  • Mosaferi ZH (2001) Effects of different irrigation regimes on saffron yield. MSc. thesis, Ferdowsi University of Mashhad, Iran

  • Mousavi SZ, Bathaie SZ (2011) Historical uses of saffron: identifying potential new avenues for modern research. Avicenna J Phytomed 1:57–66

    Google Scholar 

  • Munshi AM, Wani SA, Tak GM (2001) Improved cultivation practices for saffron. In: Proceedings of seminar-cum-workshop on saffron (Crocus Sativus), pp 83–88

  • Mushtaq A, Gul Z, Mehfuza H, Ameeque A, Dar NA, Dar ZA (2014) Saffron (Crocus sativus L.) in the light of biotechnological approaches: a review. Sci Res Essays 9:13–18. https://doi.org/10.5897/sre2013.5773

    Article  Google Scholar 

  • Nehvi FA (2010) Forthcoming challenges for improving saffron farming systems in Kashmir. Acta Hortic 850:281–286. https://doi.org/10.17660/ActaHortic.2010.850.48

    Article  Google Scholar 

  • Nehvi FA, Makhdoomi MI (2007) Importance of irrigation in saffron production. Indian Farm 59:15–16

    Google Scholar 

  • Nehvi FA, Ghani MY, Dar SA, Allaie BA (2008) Saffron production technology. In: Nehvi FA, Wani SA (eds) Saffron Prod. Jammu Kashmir, Dir. Ext. Educ. SKUAST-K, India, pp 114–141

  • Ohba T, Ishisaka M, Tsujii S, Tsuruma K, Shimazawa M, Kubo K, Umigai N, Iwawaki T, Hara H (2016) Crocetin protects ultraviolet A-induced oxidative stress and cell death in skin in vitro and in vivo. Eur J Pharmacol 789:244–253. https://doi.org/10.1016/j.ejphar.2016.07.036

    Article  CAS  PubMed  Google Scholar 

  • Omidi H, Naghdibadi HA, Golzad A, Torabi H, Fotookian MH (2009) Effects of chemical and biological nitrogen fertilizers on quantitative and qualitative yield of saffron (Crocus sativus L.). J Med Plants 9:98–109

    Google Scholar 

  • Papandreou MA, Kanakis CD, Polissiou MG, Efthimiopoulos S, Cordopatis P, Margarity M, Lamari FN (2006) Inhibitory activity on amyloid-β aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents. J Agric Food Chem 54:8762–8768. https://doi.org/10.1021/jf061932a

    Article  CAS  PubMed  Google Scholar 

  • Parizad S, Dizadji A, Habibi MK, Winter S, Kalantari S, Movi S, Lorenzo Tendero C, Alonso GL, Moratalla-Lopez N (2019) The effects of geographical origin and virus infection on the saffron (Crocus sativus L.) quality. Food Chem 295:387–394. https://doi.org/10.1016/j.foodchem.2019.05.116

    Article  CAS  PubMed  Google Scholar 

  • Pazoki A, Kariminejad M, Targhi AF (2013) Effect of planting patterns on yield and some agronomical traits in saffron (Crocus sativus L.) under different irrigation intervals in Shahr-e-Rey Region. Int J farm Allied Sci 2(S2):1363–1368

    Google Scholar 

  • Petrakis EA, Polissiou MG (2017) Assessing saffron (Crocus sativus L.) adulteration with plant-derived adulterants by diffuse reflectance infrared Fourier transform spectroscopy coupled with chemometrics. Talanta 162:558–566. https://doi.org/10.1016/j.talanta.2016.10.072

    Article  CAS  PubMed  Google Scholar 

  • Petrakis EA, Cagliani LR, Polissiou MG, Consonni R (2015) Evaluation of saffron (Crocus sativus L.) adulteration with plant adulterants by 1H NMR metabolite fingerprinting. Food Chem 173:890–896. https://doi.org/10.1016/j.foodchem.2014.10.107

    Article  CAS  PubMed  Google Scholar 

  • Pitsikas N (2016) Constituents of saffron (Crocus sativus L.) as potential candidates for the treatment of anxiety disorders and schizophrenia. Molecules 21:303–314. https://doi.org/10.3390/molecules21030303

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pitsikas N, Boultadakis A, Georgiadou G, Tarantilis PA, Sakellaridis N (2008) Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety. Phytomedicine 15:1135–1139. https://doi.org/10.1016/j.phymed.2008.06.005

    Article  CAS  PubMed  Google Scholar 

  • Qadri B (2018) Examining saffron income and choice of marketing channel connection. Agric Water Manag 7:25–30

    Google Scholar 

  • Qibin L (2015) Method of planting saffron crocus in Tibet region. China patent CN104584830A

  • Rahaiee S, Moini S, Hashemi M, Shojaosadati SA (2015) Evaluation of antioxidant activities of bioactive compounds and various extracts obtained from saffron (Crocus sativus L.): a review. J Food Sci Technol 52:1881–1888. https://doi.org/10.1007/s13197-013-1238-x

    Article  CAS  PubMed  Google Scholar 

  • Rahimi H, Shokrpour M, Tabrizi Raeini L, Esfandiari E (2017) A study on the effects of environmental factors on vegetative characteristics and corm yield of saffron (Crocus sativus). Iran J Hortic Sci 48:45–52

    Google Scholar 

  • Raja ASM, Pareek PK, Shakyawar DB, Wani SA, Nehvi FA, Sofi AH (2012) Extraction of natural dye from saffron flower waste and its application on pashmina fabric. Adv Appl Sci Res 3:156–161

    CAS  Google Scholar 

  • Razak SIA, Anwar Hamzah MS, Yee FC, Kadir MRA, Nayan NHM (2017) A review on medicinal properties of saffron toward major diseases. J Herbs Spices Med Plants 23:98–116. https://doi.org/10.1080/10496475.2016.1272522

    Article  CAS  Google Scholar 

  • Righi V, Parenti F, Tugnoli V, Schenetti L, Mucci A (2015) Crocus sativus petals: waste or valuable resource? The answer of high-resolution and high-resolution magic angle spinning nuclear magnetic resonance. J Agric Food Chem 63:8439–8444. https://doi.org/10.1021/acs.jafc.5b03284

    Article  CAS  PubMed  Google Scholar 

  • Salwee Y, Nehvi FA (2013) Saffron as a valuable spice: a comprehensive review. Afr J Agric Res 8:234–242

    Google Scholar 

  • Samarghandian S, Borji A (2014) Anticarcinogenic effect of saffron (Crocus sativus L.) and its ingredients. Pharmacogn Res 6:99–107. https://doi.org/10.4103/0974-8490.128963

    Article  Google Scholar 

  • Samarghandian S, Borji A, Farahmand SK, Afshari R, Davoodi S (2013) Crocus sativus L. (saffron) stigma aqueous extract induces apoptosis in alveolar human lung cancer cells through caspase-dependent pathways activation. Biomed Res Int 2013:1–12. https://doi.org/10.1155/2013/417928

    Article  Google Scholar 

  • Sameer SS, Bashir S, Nehvi FA, Iqbal AM, Naseer S, Nagoo SA, Dar NA (2018) Effect of biofertilizers, biological control agents and soil amendments on the control of saffron corm rot (Crocus sativus L.). Acta Hortic 1200:121–124

    Article  Google Scholar 

  • Sepaskhah ALIR, Kamgar HAA (2009) Saffron irrigation regime. Int J Plant Prod 3:1–16. https://www.sid.ir/en/Journal/ViewPaper.aspx?ID=175240

  • Serrano-Diaz J, Sanchez AM, Maggi L, Martinez-Tome M, Garcia-Diz L, Murcia MA, Alonso GL (2012) Increasing the applications of Crocus sativus flowers as natural antioxidants. J Food Sci 77:1162–1168. https://doi.org/10.1111/j.1750-3841.2012.02926.x

    Article  CAS  Google Scholar 

  • Serrano-Diaz J, Sanchez AM, Martinez-Tome M, Winterhalter P, Alonso GL (2014) Flavonoid determination in the quality control of floral bioresidues from Crocus sativus L. J Agric Food Chem 62(14):3125–3133

    Article  CAS  PubMed  Google Scholar 

  • Shahi T, Assadpour E, Jafari SM (2016) Main chemical compounds and pharmacological activities of stigmas and tepals of ‘red gold’; saffron. Trends Food Sci Technol 58:69–78. https://doi.org/10.1016/j.tifs.2016.10.010

    Article  CAS  Google Scholar 

  • Sharafzadeh S (2011) Saffron: a concise review of researches. Adv Environ Biol 5:1617–1622

    Google Scholar 

  • Shufeng L, Jingbin L, Yun G, Lei W, Hua L (2016) Portable saffron harvesting machine. China patent CN102860176B

  • Siracusa L, Napoli EM, Ruberto G, Gresta F, Lombardo GM (2010) Effect of corms storage conditions on quantitative and qualitative traits of saffron: an agro-chemical study. Acta Hortic 850:185–188. https://doi.org/10.17660/ActaHortic.2010.850.30

    Article  Google Scholar 

  • Srivastava R, Ahmed H, Dixit RK, Dharamveer Saraf SA (2010) Crocus sativus L.: a comprehensive review. Pharmacogn Rev 4:200–208. https://doi.org/10.4103/0973-7847.70919

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sudha JK, Patil AB, Aneesh SS, Bhise KS, Pradip BD, Sashikant AD (2015) Method for extracting saffron crocus essential oil. India patent IN2015MU01663A

  • Tammaro F (1990) Crocus sativus L.: environment, cultivation, morphometric characteristics, active principles, uses. In: Tammaro F, Marra L (eds) Proceedings of the international conference on saffron, pp 47–57

  • Trigoso CI, Stockert JC (1995) Fluorescence of the natural dye saffron: selective reaction with eosinophil leucocyte granules. Histochem Cell Biol 104:75–77. https://doi.org/10.1007/BF01464789

    Article  CAS  PubMed  Google Scholar 

  • United states department of agriculture (2020) Natural resources conservation service. Classification | USDA PLANTS. https://plants.usda.gov/java/ClassificationServlet?source=display&classid=CROCU. Accessed 1 Jan 2021

  • Usan (2013) Cultivation method of saffron. China patent CN103299795A

  • Varliklioz Er S, Eksi-Kocak H, Yetim H, Boyaci IH (2017) Novel spectroscopic method for determination and quantification of saffron adulteration. Food Anal Methods 10:1547–1555. https://doi.org/10.1007/s12161-016-0710-4

    Article  Google Scholar 

  • Wali, E., Datta, A., Shrestha, R. P., & Shrestha, S. (2016). Development of a land suitability model for saffron (Crocus sativus L.) cultivation in Khost Province of Afghanistan using GIS and AHP techniques. Arch Agron Soil sci, 62(7), 921–934.

    Article  CAS  Google Scholar 

  • Wang Y, Sun J, Liu C, Fang C (2014) Protective effects of crocetin pretreatment on myocardial injury in an ischemia/reperfusion rat model. Eur J Pharmacol 741:290–296. https://doi.org/10.1016/j.ejphar.2014.07.052

    Article  CAS  PubMed  Google Scholar 

  • Wei L (2013) Sinkiang saffron planting technology. China patent CN101904267B

  • Xiaodong Q, Chong Y, Jiang Fengqin (2015) Method for cultivating saffron buds. China patent CN103782790B

  • Yarami N, Sepaskhah AR (2015) Saffron response to irrigation water salinity, cow manure and planting method. Agric Water Manag 150:57–66

    Article  Google Scholar 

  • Yasmin S, Nehvi F (2018) Phenological growth stages of Saffron (Crocus sativus L.) under temperate conditions of Jammu and Kashmir-India. Int J Curr Microbiol App Sci 7:3797–3814

    Article  Google Scholar 

  • Ye H, Wei Z, Yawen J, Yanhai C (2015) Saffron corms propagation method. China patent CN104782368A

  • Yildirim MU, Asil H, Hajyzadeh M, Sarihan EO, Khawar KM (2017) Effect of changes in planting depths of saffron (Crocus sativus L.) corms and determining their agronomic characteristics under warm and temperate (Csa) climatic conditions of Turkish province of Hatay. Acta Hortic 1184:47–53. https://doi.org/10.17660/ActaHortic.2017.1184.7

    Article  Google Scholar 

  • Zahmati R, Shekari HA, Fotokian MH (2018) Growth and development of saffron (Crocus sativus L.) in response to temperature pre-treatment and environmental conditions. J Biosci Biotechnol 7:47–50

    Google Scholar 

  • Zare Hosseini H, Ghorbani R, Mohassel R, Hassan M, Rahimi H (2014) Effects of weed management strategies on weed density and biomass and saffron (Crocus sativus) yield. J Saffron Agron Technol 2:45–58

    Google Scholar 

  • Zeka K, Ruparelia KC, Continenza MA, Stagos D, Vegliò F, Arroo RRJ (2015) Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol. Fitoterapia 107:128–134. https://doi.org/10.1016/j.fitote.2015.05.014

    Article  CAS  PubMed  Google Scholar 

  • Zhang A, Shen Y, Cen M, Hong X, Shao Q, Chen Y, Zheng B (2019) Polysaccharide and crocin contents, and antioxidant activity of saffron from different origins. Ind Crops Prod 133:111–117. https://doi.org/10.1016/j.indcrop.2019.03.009

    Article  CAS  Google Scholar 

  • Zhiming Z (2014) Saffron crocus planting method. China patent CN103814734A

  • Ziying X, Qun L (2012) Saffron series of plant colorful hair dying cream. China patent CN102078276

  • Ziyu Z (2014) Method for extracting saffron crocus essential oil. China patent CN103805340A

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Acknowledgements

The authors are grateful to the Director, CSIR-IHBT, Palampur, for providing the necessary facilities during this study. The authors are thankful to Er Amit Kumar, Senior Principal Scientist, CSIR-IHBT for plotting the figure of saffron introduction. Financial assistance received under the project “Introduction of high value spice saffron (Crocus sativus L.) in un-explored areas (MLP 0127)” from the Council of Scientific and Industrial Research, New Delhi is acknowledged. This is CSIR-IHBT Manuscript Number 4666.

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Authors and Affiliations

  1. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

    Deepak Kothari & Rakesh Kumar

  2. Agrotechnology Division, CSIR-Institute of Himalayan Bioresource Technology, (Council of Scientific and Industrial Research), Post-Box No. 6, Palampur, HP, 176 061, India

    Deepak Kothari, Rajesh Thakur & Rakesh Kumar

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  1. Deepak Kothari
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Overall planning, guidance, paper editing was done by Dr. Rakesh Kumar. Deepak Kothari and Rajesh Thakur searched the literature and prepared the manuscript.

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Kothari, D., Thakur, R. & Kumar, R. Saffron (Crocus sativus L.): gold of the spices—a comprehensive review. Hortic. Environ. Biotechnol. 62, 661–677 (2021). https://doi.org/10.1007/s13580-021-00349-8

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