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Therapeutic potential of miRNAs in placental extracellular vesicles in ovarian and endometrial cancer

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Abstract

There is a cross-link between the placenta and cancer development, as the placenta is grown as a highly invasive tumour-like organ. However, placental development is strictly controlled. Although the underlying mechanism of this control is largely unknown, it is now well-recognised that extracellular vesicles (EVs) released from the placenta play an important role in controlling placenta proliferation and invasion, as placental EVs have shown their effect on regulating maternal adaptation. Better understanding the tumour-like mechanism of the placenta could help to develop a therapeutic potential in cancers. In this study, by RNA sequencing of placental EVs, 20 highly expressed microRNAs (miRNAs) in placental EVs were selected and analysed for their functions on ovarian and endometrial cancer. There were up to seven enriched miRNAs, including miRNA-199a-3p, miRNA-143-3p, and miRNA-519a-5p in placental EVs showing effects on the inhibition of ovarian and endometrial cancer cell proliferation and migration, and promotion of cancer cell death, reported in the literature. Most of these miRNAs have been reported to be downregulated in ovarian and endometrial cancer. Transfection of ovarian and endometrial cancer cells with mimics of miRNA-199a-3p, miRNA-143-3p, and miRNA-519a-5p significantly reduced the cell viability. Our findings could provide strategies for using these naturally occurring miRNAs to develop a novel method to treat ovarian and endometrial cancer in the future.

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Data availability

The datasets used and/or analysed during the current study are available from the corresponding author upon reasonable request.

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Acknowledgements

This study was supported by the Outstanding Talent Project of Wuxi Health and Family Planning Commission of China (ZDRC023 to M Zhao) and the Outstanding Talent Project of Wuxi Maternity and Child Health Hospital affiliated with Nanjing Medical University. The authors would like to thank the women who donated the placentae for this study.

Funding

Wuxi Health and Family Planning Commission, Z202104, Min Zhao

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Author notes

  1. Yi Zhang and Yunhui Tang equally contributed to this study.

Authors and Affiliations

  1. Department of Obstetrics & Gynaecology, The University of Auckland, Auckland, New Zealand

    Yi Zhang, Xinyue Chen, Xinyi Sun & Qi Chen

  2. Department of Family Planning, The Hospital of Obstetrics & Gynaecology, Fudan University, Shanghai, China

    Yunhui Tang

  3. Department of Gynaecological Cancer, Wuxi School of Medicine, Wuxi Maternity and Child Health Hospital, Jiangnan University, Wuxi, Jiangsu, China

    Min Zhao

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  1. Yi Zhang
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Contributions

All authors were involved in the drafting, editing, and approval of the manuscript for publication. In addition to this, each author contributed to the following work: YZ, YW, XC, XS: data analysis. YT: sampling. MZ, YT, and QC: study design and completion of the final manuscript.

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Correspondence to Min Zhao.

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All authors have no conflict of interest to report.

Data loading information

The raw miRNA sequencing data included in this study have been uploaded to European Nucleotide Archive (accession number: PRJEB44935), visiting http://www.ebi.ac.uk/ena/data/view/PRJEB44935​ can directly link to the raw data. The raw mRNA sequencing data included in this study have been uploaded to the GEO database (accession number: GSE243543) with the link https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE243543.

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Zhang, Y., Tang, Y., Chen, X. et al. Therapeutic potential of miRNAs in placental extracellular vesicles in ovarian and endometrial cancer. Human Cell 37, 285–296 (2024). https://doi.org/10.1007/s13577-023-00986-4

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