Data availability
The data presented in this study is accessible via https://singlecell.broadinstitute.org.
References
El-Arabey AA, Abdalla M. Cardiovascular complications in the post-acute COVID-19 syndrome: a novel perspective down the road. Travel Med Infect Dis. 2022;49:102421. https://doi.org/10.1016/j.tmaid.2022.102421.
Castiello T, Georgiopoulos G, Finocchiaro G, Claudia M, Gianatti A, Delialis D, Aimo A, Prasad S. COVID-19 and myocarditis: a systematic review and overview of current challenges. Heart Fail Rev. 2022;27:251–61. https://doi.org/10.1007/s10741-021-10087-9.
Abumrad NA, Cabodevilla AG, Samovski D, Pietka T, Basu D, Goldberg IJ. Endothelial cell receptors in tissue lipid uptake and metabolism. Circ Res. 2021;128:433–50. https://doi.org/10.1161/circresaha.120.318003.
Yagyu H, Chen G, Yokoyama M, Hirata K, Augustus A, Kako Y, Seo T, Hu Y, Lutz EP, Merkel M, et al. Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy. J Clin Investig. 2003;111:419–26. https://doi.org/10.1172/jci16751.
Saxena U, Witte LD, Goldberg IJ. Release of endothelial cell lipoprotein lipase by plasma lipoproteins and free fatty acids. J Biol Chem. 1989;264:4349–55.
Young SG, Fong LG, Beigneux AP, Allan CM, He C, Jiang H, Nakajima K, Meiyappan M, Birrane G, Ploug M. GPIHBP1 and lipoprotein lipase, partners in plasma triglyceride metabolism. Cell Metab. 2019;30:51–65. https://doi.org/10.1016/j.cmet.2019.05.023.
Trent CM, Yu S, Hu Y, Skoller N, Huggins LA, Homma S, Goldberg IJ. Lipoprotein lipase activity is required for cardiac lipid droplet production. J Lipid Res. 2014;55:645–58. https://doi.org/10.1194/jlr.M043471.
Zhong P, Wang Z, Du Z. Serum triglyceride levels and related factors as prognostic indicators in COVID-19 patients: a retrospective study. Immun Inflamm Dis. 2021;9:1055–60. https://doi.org/10.1002/iid3.469.
Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe A, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, et al. A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2. BioRxiv Preprint Server Biol. 2021. https://doi.org/10.1101/2021.02.25.430130.
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AAE-A and ZG: designed the idea and writing the original draft preparation. MA: writing the original draft preparation and writing review and editing. All authors have read and agreed to the published version of the manuscript.
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Abdalla, M., El-Arabey, A.A. & Gai, Z. Interplay between LPL and GPIHBP1 in COVID-19 patients: a possible mechanism for post-recovery cardiomyopathy. Human Cell 36, 2270–2272 (2023). https://doi.org/10.1007/s13577-023-00953-z
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DOI: https://doi.org/10.1007/s13577-023-00953-z