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Zoledronate increases enrichment, activation and expansion of natural killer cells from umbilical cord blood

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References

  1. Kondo M, Sakuta K, Noguchi A, Ariyoshi N, Sato K, Sato S, Sato K, Hosoi A, Nakajima J, Yoshida Y, Shiraishi K, Nakagawa K, Kakimi K. Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy. Cytotherapy. 2008;10:842–56.

    Article  PubMed  CAS  Google Scholar 

  2. Kobayashi H, Tanaka Y. gammadelta T Cell Immunotherapy: a review Pharmaceuticals (Basel). 2015;8:40–61.

    Article  CAS  Google Scholar 

  3. Alnabhan R, Madrigal A, Saudemont A. Differential activation of cord blood and peripheral blood natural killer cells by cytokines. Cytotherapy. 2015;17:73–85.

    Article  PubMed  CAS  Google Scholar 

  4. Luevano M, Daryouzeh M, Alnabhan R, Querol S, Khakoo S, Madrigal A, Saudemont A. The unique profile of cord blood natural killer cells balances incomplete maturation and effective killing function upon activation. Hum Immunol. 2012;73:248–57.

    Article  PubMed  CAS  Google Scholar 

  5. Berglund S, Gaballa A, Sawaisorn P, Sundberg B, Uhlin M. Expansion of gammadelta T cells from cord blood: a therapeutical possibility. Stem Cells Int. 2018; 2018:8529104.

  6. Cany J, Dolstra H, Shah N. Umbilical cord blood-derived cellular products for cancer immunotherapy. Cytotherapy. 2015;17:739–48.

    Article  PubMed  Google Scholar 

  7. Shimasaki N, Coustan-Smith E, Kamiya T, Campana D. Expanded and armed natural killer cells for cancer treatment. Cytotherapy. 2016;18:1422–34.

    Article  PubMed  CAS  Google Scholar 

  8. Shaim H, Yvon E. Cord blood: a promising source of allogeneic natural killer cells for immunotherapy. Cytotherapy. 2015;17:1–2.

    Article  PubMed  Google Scholar 

  9. Mehta RS, Shpall EJ, Rezvani K. Cord blood as a source of natural killer cells. Front Med (Lausanne). 2015;2:93.

    Google Scholar 

  10. Xing D, Ramsay AG, Gribben JG, Decker WK, Burks JK, Munsell M, Li S, Robinson SN, Yang H, Steiner D, Shah N, McMannis JD, Champlin RE, Hosing C, Zweidler-McKay PA, Shpall EJ, Bollard CM. Cord blood natural killer cells exhibit impaired lytic immunological synapse formation that is reversed with IL-2 exvivo expansion. J Immunother. 2010;33:684–96.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Acknowledgements

This work was supported by the Natural Science Foundation of Inner Mongolia (No. 2017MS0314).

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Authors and Affiliations

  1. Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, China

    Zhijie Ma

  2. Center for Tissue Engineering and Technology of Inner Mongolia, Hohhot, Inner Mongolia, China

    Yunhong Wang & Xiaoyun Wu

  3. Beijing Jingmeng Stem Cell Technology Co., Ltd, Beijing, China

    Huiyan Kang & Xiaoyun Wu

  4. Beijing Institute of Life Science Translational Medicine Research Center, No. 5-2, Shangdi East Road, Beijing, China

    Xiaoyun Wu

Authors
  1. Zhijie Ma
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  2. Yunhong Wang
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  3. Huiyan Kang
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  4. Xiaoyun Wu
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Corresponding author

Correspondence to Xiaoyun Wu.

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Conflict of interest

A patent application for the composition for expanding NK cells and the use of them has been filed with Xiaoyun Wu as a first inventor. Other authors (ZJM and HYK) declare that they have no conflict of interest.

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Ma, Z., Wang, Y., Kang, H. et al. Zoledronate increases enrichment, activation and expansion of natural killer cells from umbilical cord blood. Human Cell 31, 310–312 (2018). https://doi.org/10.1007/s13577-018-0213-2

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  • DOI: https://doi.org/10.1007/s13577-018-0213-2

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