Expression of miR-132 in Down syndrome subjects
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Down syndrome (DS) is caused by the presence of three human chromosome 21 copies, this trisomy is the most frequent genetic etiology associated with a number of deleterious phenotypes in humans, where is included intellectual disability .
Gene expression plays a central role in neuronal plasticity and in dysfunction of the molecular events that can lead to severe neuronal disorders.
In addition, to coding transcripts (mRNAs), non-coding microRNAs (miRNAs) appear to play a role in these processes . MiRNAs are short non-coding RNAs (∼ 22 nucleotide) that mediate post-transcriptional gene silencing . MiRNAs play a role in early neuronal development and in neurodegenerative diseases .
Previous studies on DS mainly focused on human chromosome 21-derived miRNAs, and few studies focused in total miRNAs expression profile from human blood samples .
Many miRNAs were detected to have significantly different expression, which may be involved in DS variable phenotypes .
KeywordsMiR-132 Intellectual disability Down syndrome mRNA expression
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The authors report no declarations of interest.
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