Human Cell

, Volume 31, Issue 3, pp 268–270 | Cite as

Expression of miR-132 in Down syndrome subjects

  • Michele Salemi
  • Concetta Barone
  • Maria Grazia Salluzzo
  • Mariaconcetta Giambirtone
  • Federico Ridolfo
  • Corrado Romano
Letter to the Editor

Dear Sir,

Down syndrome (DS) is caused by the presence of three human chromosome 21 copies, this trisomy is the most frequent genetic etiology associated with a number of deleterious phenotypes in humans, where is included intellectual disability [1].

Gene expression plays a central role in neuronal plasticity and in dysfunction of the molecular events that can lead to severe neuronal disorders.

In addition, to coding transcripts (mRNAs), non-coding microRNAs (miRNAs) appear to play a role in these processes [2]. MiRNAs are short non-coding RNAs (∼ 22 nucleotide) that mediate post-transcriptional gene silencing [3]. MiRNAs play a role in early neuronal development and in neurodegenerative diseases [4].

Previous studies on DS mainly focused on human chromosome 21-derived miRNAs, and few studies focused in total miRNAs expression profile from human blood samples [5].

Many miRNAs were detected to have significantly different expression, which may be involved in DS variable phenotypes [6].


MiR-132 Intellectual disability Down syndrome mRNA expression 


Compliance with ethical standards

Conflict of interest

The authors report no declarations of interest.


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Copyright information

© Japan Human Cell Society and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Oasi Research Institute-IRCCSTroinaItaly
  2. 2.Department of Transfusional MedicineGeneral Hospital of TrevisoTrevisoItaly

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