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Human Cell

, Volume 31, Issue 3, pp 232–241 | Cite as

Long non-coding RNA (lncRNA) MAGI2-AS3 inhibits breast cancer cell growth by targeting the Fas/FasL signalling pathway

Research Article

Abstract

Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts shown to play important roles in tumourigenesis and tumour progression. Our study aimed to examine expression of the lncRNA MAGI2-AS3 in breast cancer and to explore its function in cancer cell growth. First, MAGI2-AS3 expression levels in clinical samples and cell lines were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The functional significance of MAGI2-AS3 in cancer cell proliferation and apoptosis was then examined in vitro. Our results showed MAGI2-AS3 to be down-regulated in breast cancer tissues compared to normal adjacent tissues. Moreover, MAGI2-AS3 markedly inhibited breast cancer cell growth and increased expression of Fas and Fas ligand (FasL). In conclusion, our data suggest that MAGI2-AS3 expression is decreased in breast cancer and that MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling. These results provide new insight into novel clinical treatments for breast cancer.

Keywords

lncRNA MAGI2-AS3 Breast cancer Proliferation Fas/FasL 

Notes

Acknowledgements

This work was supported by Grants from the National Natural Science Foundation of China (No. 81602330) and the Natural Scientific Foundation of Shandong Province (No. ZR2015PH056). We also thank professor Sun of Jiangsu University for providing all of the cell lines.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Japan Human Cell Society and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Yong Yang
    • 1
  • Hong Yang
    • 2
  • Miao Xu
    • 3
  • Haibin Zhang
    • 4
  • Mingtao Sun
    • 5
  • Peng Mu
    • 5
  • Tongbao Dong
    • 5
  • Shanmei Du
    • 5
  • Kui Liu
    • 6
  1. 1.Affiliated Hospital of Taishan Medical UniversityTai’anPeople’s Republic of China
  2. 2.Central Hospital of Tai’an CityTai’anPeople’s Republic of China
  3. 3.The Seventh People’s Hospital of ZiboZiboPeople’s Republic of China
  4. 4.Qingzhou People’s HospitalQingzhouPeople’s Republic of China
  5. 5.Zibo Vocational InstituteZiboPeople’s Republic of China
  6. 6.Center of Translational MedicineZibo Central HospitalZiboPeople’s Republic of China

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