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Human Cell

, Volume 31, Issue 2, pp 179–181 | Cite as

Mitochondrial mRNA expression in fibroblasts of Down syndrome subjects

  • Michele Salemi
  • Mariaconcetta Giambirtone
  • Concetta Barone
  • Maria Grazia Salluzzo
  • Roberto Russo
  • Mariangela Lo Giudice
  • Salvatore Cutuli
  • Federico Ridolfo
  • Corrado Romano
Letter to the Editor

Dear Sir,

In Wong’s article it was highlighted that mitochondrial activity disregulation may affect early onset of Alzheimer’s in subjects with Down syndrome (DS) [1].

From this study, we have taken the lead to evaluate the expression of the various mitochondrial subunits in subjects with DS.

Trisomy 21 or Down syndrome is caused by the presence of three copies of the whole human chromosome (HC) 21, or of a HC21 restricted region, and is the most frequent genetic etiology of intellectual disability in humans [2]. Adults with DS usually develop neuropathological changes typical of Alzheimer’s disease (AD) in the fifth decade of life and clinical features of AD are noted in 75% of such individuals over 60 years of age [3].

Altered mitochondrial activity has been associated with DS and AD pathogenesis [4, 5, 6]. Complex I is the first step in the electron transport chain of mitochondrial oxidative phosphorylation (OXPHOS) and is located within mitochondrial inner membrane, it accepts...

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

References

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Copyright information

© Japan Human Cell Society and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Michele Salemi
    • 1
  • Mariaconcetta Giambirtone
    • 1
  • Concetta Barone
    • 1
  • Maria Grazia Salluzzo
    • 1
  • Roberto Russo
    • 1
  • Mariangela Lo Giudice
    • 1
  • Salvatore Cutuli
    • 1
  • Federico Ridolfo
    • 2
  • Corrado Romano
    • 1
  1. 1.Oasi Research Institute-IRCCSTroinaItaly
  2. 2.Department of Transfusion MedicineGeneral Hospital of Treviso, ULSS 2 Marca TrevigianaTrevisoItaly

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