Mitochondrial mRNA expression in fibroblasts of Down syndrome subjects
In Wong’s article it was highlighted that mitochondrial activity disregulation may affect early onset of Alzheimer’s in subjects with Down syndrome (DS) .
From this study, we have taken the lead to evaluate the expression of the various mitochondrial subunits in subjects with DS.
Trisomy 21 or Down syndrome is caused by the presence of three copies of the whole human chromosome (HC) 21, or of a HC21 restricted region, and is the most frequent genetic etiology of intellectual disability in humans . Adults with DS usually develop neuropathological changes typical of Alzheimer’s disease (AD) in the fifth decade of life and clinical features of AD are noted in 75% of such individuals over 60 years of age .
Altered mitochondrial activity has been associated with DS and AD pathogenesis [4, 5, 6]. Complex I is the first step in the electron transport chain of mitochondrial oxidative phosphorylation (OXPHOS) and is located within mitochondrial inner membrane, it accepts...
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Conflict of interest
The authors declare that they have no competing interests.