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Five-year results of post-prostatectomy patients administered a hydrogel rectal spacer implant in conjunction with dose escalated external beam radiation therapy

  • Original Research
  • Published:
Journal of Radiation Oncology

Abstract

Objective

This study reports on the 5-year biochemical-relapse free survival (bRFS), and late gastrointestinal (GI) and genitourinary (GU) toxicities of patients who underwent a prostatectomy and received high dose (> 72 Gy) radiation therapy with an absorbable polyethylene glycol (PEG) rectal spacer implant.

Methods

From January 2010 to October 2013, 21 radical prostatectomy patients received a PEG spacer. GI and GU toxicities were scored using the National Cancer Center Institute Common Terminology Criteria for Adverse Events v4.0 grading scheme. bRFS was tallied and segregated into risk groups according to the National Cancer Comprehensive Network (NCCN) guidelines version 1.2016. Cox regression multivariate analysis was performed to elicit disease risk factors.

Results

The mean follow-up time was 59 months (SD 12, range 40–97). Our GI toxicities for acute, 3 months, and after 6 months are as follows: grade 0 (57%, 86%, 86%), grade 1 (43%, 14%, 14%), and grade 2 (0%, 0%, 5%). Our GU toxicities for acute, 3 months, and after 6 months are as follows: grade 0 (43%, 48%, 62%), grade 1 (48%, 43%, 24%), and grade 2 (10%, 5%, 14%). There were no late grade 3 GI/GU toxicities. The 5-year overall bRFS rate was 62.2% (95% CI 42.6–90.9%, SE 12.0%). Multivariate logistic regression analysis revealed positive surgical resection margins to be predictive (p = 0.00037) for decreased biochemical control.

Conclusion

Hydrogel rectal spacer implants in patients who previously had a prostatectomy is well tolerated long term with reduced incidence of GI and GU toxicities, and bRFS rates consistent with previous reports in the literature.

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Author information

Author notes

  1. Brandon M. Lehrich and H. Michael Moyses contributed equally to this work.

Authors and Affiliations

  1. Department of Radiation Oncology, Cancer Center of Irvine, 16100 Sand Canyon Ste #130, Irvine, CA, 92618, USA

    Brandon M. Lehrich, H. Michael Moyses, John Ravera, Jeffrey Yoshida, Robert Torrey, Ruben Baghdassarian, Michael Gazzaniga, Alan Weinberg, Cu Phan, Stuart Chalfin, Lucy Barnes, Albert Mesa & Kenneth Tokita

Authors
  1. Brandon M. Lehrich
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  2. H. Michael Moyses
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  3. John Ravera
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  4. Jeffrey Yoshida
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  7. Michael Gazzaniga
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  11. Lucy Barnes
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  13. Kenneth Tokita
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Contributions

(i) Conception and design: BML, HMM, KT; (ii) administrative support: HMM, KT; (iii) provision of study materials or patients: HMM, KT; (iv) collection and assembly of data: BML, HMM, LB, AM; (v) data analysis and interpretation: BML, HMM, LB, AM, KT; (vi) manuscript writing—original draft: BML; (vii) final approval of manuscript: all authors.

Corresponding author

Correspondence to Kenneth Tokita.

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Funding

A portion of the study was funded by the Medici Foundation (non-profit organization).

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Lehrich, B.M., Moyses, H.M., Ravera, J. et al. Five-year results of post-prostatectomy patients administered a hydrogel rectal spacer implant in conjunction with dose escalated external beam radiation therapy. J Radiat Oncol 8, 31–38 (2019). https://doi.org/10.1007/s13566-018-0369-0

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  • DOI: https://doi.org/10.1007/s13566-018-0369-0

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