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The effect of resveratrol administration in irradiated mice on the induction of micronuclei in bone marrow

  • Original Research
  • Published:
Journal of Radiation Oncology

Abstract

Objective

Resveratrol (RSV) a medicinal polyphenol is synthesized by many plants in response to injury, infection, stress, and ultraviolet (UV) irradiation, present in the grapes, nuts, fruits, and wine.

Methods

In this study, we have investigated the antioxidant ability of RSV and its activity in the protection of radiation-induced DNA injury in X-radiated mice. The antioxidant strength of RSV was evaluated by the study of the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging properties.

Results

Our results demonstrated that RSV shows strong antioxidant activity by this assay. When mice were exposed to 2 Gy X-radiation, there was an increase in the total MnPCE value and a decrease in the ratio [PCEs/ (PCEs + NCEs)] of bone marrow cells. RSV (50 mg/kg) pretreatment remarkably decreased the total MnPCE value and increased the ratio [PCEs/ (PCEs + NCEs)] in irradiated mice.

Conclusions

These results propose that RSV protects X-radiation-induced DNA damage in mice bone marrow cells, which may be related to its antioxidant activity.

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Authors and Affiliations

  1. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Hezar Jerib Avenue, Isfahan, Iran

    Farideh Koohian, Ahmad Shanei & Daryoush Shahbazi-Gahrouei

  2. Department of Parasitology & Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    Seyed Hossein Hejazi

  3. Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

    Amirhossein Ahmadi

  4. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    Mohammadreza Sharifi

Authors
  1. Farideh Koohian
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  2. Ahmad Shanei
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  3. Daryoush Shahbazi-Gahrouei
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  4. Seyed Hossein Hejazi
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  5. Amirhossein Ahmadi
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  6. Mohammadreza Sharifi
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Corresponding author

Correspondence to Ahmad Shanei.

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Funding

The work was supported by a grant number 394667 from Isfahan University of Medical Sciences (IRAN).

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

All human and animal studies have been approved by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Statement of informed consent was not applicable since the manuscript does not contain any patient data.

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Koohian, F., Shanei, A., Shahbazi-Gahrouei, D. et al. The effect of resveratrol administration in irradiated mice on the induction of micronuclei in bone marrow. J Radiat Oncol 6, 423–427 (2017). https://doi.org/10.1007/s13566-017-0324-5

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  • DOI: https://doi.org/10.1007/s13566-017-0324-5

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