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Clinical outcomes following stereotactic body radiation therapy (SBRT) for non-resectable pancreatic adenocarcinoma

Journal of Radiation Oncology volume 6, pages 279–286 (2017)Cite this article

Abstract

Objectives

The purpose of this study was to report on progression-free survival (PFS), overall survival (OS), and related toxicities following stereotactic body radiation therapy (SBRT) for non-resectable pancreatic cancer (PCa).

Methods

The RSSearch® Patient Registry was screened for PCa patients treated with SBRT. The relationship between PFS, OS, and potential prognostic factors were evaluated using the Kaplan-Meier method and continuous log-rank analysis, and the correlation between treatment planning and toxicity incidence was examined by logistic regression.

Results

Sixty patients met inclusion criteria. Twenty-three patients (38.33%) had received adjuvant gemcitabine. Following SBRT, median PFS was 6.07 months (range: 2.33 - 34.4 months) and median OS was 8.55 months (range: 2.66 - 78.53 months). Single-fraction SBRT trended towards poorer median PFS (5.13 vs. 6.76 months; p = 0.0122) with no significant difference in median OS (10.3 vs. 7.17 months; p = 0.8896). PCas located in the head had a significantly higher median OS (9.58 months) as compared to those in the body (5.66 months; p = 0.0376). Adjuvant gemcitabine did not result in superior PFS (5.12 vs. 6.35 months; p = 0.52) or OS (8.67 vs. 7.07 months; p = 0.6010). Eight (13.3%) and six (10%) patients reported acute and late toxicities, respectively, that were all Grade 1 or 2. Single-fraction SBRT was associated with an increased risk of toxicity incidence (5/9 patients vs. 3/51 patients; p = 0.001).

Conclusion

SBRT was well-tolerated by PCa patients with fractionated SBRT trending towards superior PFS and less toxicity as compared to single-fraction SBRT.

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Acknowledgements

We would like to thank all of the participating physicians, patients, and administrators of the RSSearch Registry that made this study possible.

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Authors and Affiliations

  1. Marshall University Joan C. Edwards School of Medicine, Huntington, WV, 25705, USA

    Raj Singh, Hayden Ansinelli & Sanjeev Sharma

  2. St. Mary’s Medical Center, 2900 1st Avenue, Huntington, WV, 25702, USA

    Sanjeev Sharma

Authors
  1. Raj Singh
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  2. Hayden Ansinelli
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  3. Sanjeev Sharma
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Corresponding author

Correspondence to Raj Singh.

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No funding was received for this study.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Singh, R., Ansinelli, H. & Sharma, S. Clinical outcomes following stereotactic body radiation therapy (SBRT) for non-resectable pancreatic adenocarcinoma. J Radiat Oncol 6, 279–286 (2017). https://doi.org/10.1007/s13566-017-0313-8

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  • DOI: https://doi.org/10.1007/s13566-017-0313-8

Keywords

  • Pancreatic adenocarcinoma
  • Radiotherapy
  • SBRT
  • Registry