Low-dose total body irradiation: an overlooked cancer immunotherapy technique
Low-dose total body irradiation (LD-TBI) has been shown to be an effective therapy for patients with hematologic malignancies. The application of this method has fallen out of favor as newer systemic therapies have been developed. Nevertheless, for management of many of these hematologic malignancies, no prospective randomized trial has shown that any other treatment is unequivocally superior to LD-TBI. The precise mechanism of action is uncertain but it is believed by some to be at least partly immunologically mediated. In this review, we shall discuss the clinical data on this method along with some new potential applications. We also discuss some of the potential immunological mechanisms behind LD-TBI and consider future possibilities.
KeywordsTBI Total body irradiation Cancer immunotherapy
Compliance with ethical standards
No funding was received for this study.
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
This article does not contain any studies with human participants performed by any of the authors.
Statement of informed consent was not applicable since the manuscript does not contain any patient data.
- 4.Chaffey JT, Rosenthal DS, Pinkus F, Hellman S (1975) Advanced lymphosarcoma treated by total body irradiation. Br J Cancer 31(SUPPL 2):441–449Google Scholar
- 5.Hoppe RT, Kushlan P, Kaplan HS, Rosenberg SA, Brown BW (1981) The treatment of advanced stage favorable histology non-Hodgkin’s lymphoma: a preliminary report of a randomized trial comparing single agent chemotherapy, combination chemotherapy, and whole body irradiation. Blood 58:592–598PubMedGoogle Scholar
- 17.Cuttler JM, Pollycove M (2003) Can cancer be treated with low doses of radiation? J Am Phys Surg 8:108–111Google Scholar
- 19.Song KH, Kim MH, Kang SM et al (2015) Analysis of immune cell populations and cytokine profiles in murine splenocytes exposed to whole-body low-dose irradiation. Int J Radiat Biol 23:1–9 [Epub ahead of print]Google Scholar
- 22.Welsh JS (2004) Waldenstrom’s Macroglobulinemia treated with fractionated low-dose total body irradiation. Case Rep Clin Pract Rev 5:CS425–CS431Google Scholar
- 25.Anonymous (1981) British National Lymphoma Investigation Report: a prospective comparison of combination chemotherapy with total body irradiation in the treatment of advanced non-Hodgkin’s lymphoma. Clin Oncol 7:193–200Google Scholar
- 32.Kollmannsberger C, Hartmann JT, Kanz L, Bokemeyer C (1998) Risk of secondary myeloid leukemia and myelodysplastic syndrome following standard-dose chemotherapy or high-dose chemotherapy with stem cell support in patients with potentially curable malignancies. J Cancer Res Clin Oncol 124(3–4):207–214CrossRefPubMedGoogle Scholar
- 47.Sakamoto K, Myogin M, Hosoi Y (1997) Fundamental and clinical studies on cancer control with total or upper half body irradiation. J Jpn Soc Ther Radiol Oncol 16:161–175Google Scholar