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Regulation of stress-induced inositol metabolism in plants: a phylogenetic search for conserved cis elements

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Journal of Plant Biochemistry and Biotechnology Aims and scope Submit manuscript


Inositol and its’ metabolic derivatives such as galactinol, raffinose, methylated inositols etc. are well known significant osmoprotectants produced in response to various abiotic stresses in plants. The present work focuses on the importance of phylogenetic analysis in search of a presumptive ‘master switch’ involved in inducing a set of stress-responsive coregulated genes in the pathways involved in inositol synthesis and its further metabolism. It can be reasonably assumed that the entire network of genes induced under a particular stress is governed by a few common stress-responsive transcription factor binding sites or cis elements in their respective promoters. A phylogenetic analysis of such regulatory regions of the coregulated genes participating in entire inositol metabolic pathway throughout evolution, can form a novel approach in recognizing the conserved stress-regulatory signature(s) or ‘master switch(es)’ regulating this important pathway under the stress impact.

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Ino1 or MIPS:

L-myo-inositol-1-phosphate synthase


Inositol methyl transferase


Galactinol synthase


Raffinose synthase


Stachyose synthase


Phospholipase C


Myo-inositol oxygenase


Inositol hexakisphosphate kinase


Cis-acting regulatory elements


Transcription factor


Transcription factor binding site


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ALM is currently an INSA Senior Scientist, while PB was supported by Institutional Research Associate fellowship


No specific funds were utilized for this work.

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ALM and PB conceptualized the idea primarily based on the previous work done in this laboratory and designed the outline of the review. PB conducted all the required supporting search, performed the bioinformatic analysis and wrote the draft manuscript. ALM reviewed and following thorough discussions finalized the same.

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Correspondence to Arun Lahiri Majumder.

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eFP data showing the genes with high inducibility under abiotic stresses- salt, drought and cold (retrieved from BAR databases for Arabidopsis and rice). Data for Arabidopsis were based on 0, 3, 6, 12 and 24 hrs of treatment for shoot and root, separately. Rice data available were of 3hrs post treatment (TIF 920 kb)

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Basak, P., Majumder, A.L. Regulation of stress-induced inositol metabolism in plants: a phylogenetic search for conserved cis elements. J. Plant Biochem. Biotechnol. 30, 756–778 (2021).

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