Abstract
Introduction
The pathogenesis of circumscribed palmar hypokeratosis (CPH) is still controversial, and to date there is no treatment of choice.
Methods
We report on a patient with CPH responding to treatment with fluorouracil cream.
Results
The clinical course and histopathological features in our observation point towards the possibility of an underlying squamous cell carcinoma in situ presenting as CPH.
Conclusion
We suggest that fluorouracil cream treatment should be considered as a therapeutic option in cases of CPH.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Pérez A, Rütten A, Gold R, et al. Circumscribed palmar or plantar hypokeratosis: a distinctive epidermal malformation of the palms and soles. J Am Acad Dermatol. 2002;47:21–27.
Obermoser G, Zelger B. “Multifocal” circumscribed palmar hypokeratosis: malformation or not? J Am Acad Dermatol. 2003;49:1197–1198.
Resnik K, DiLeonardo M. Circumscribed palmar hypokeratosis. New observations. Am J Dermatopathol. 2006;28:112–116.
Ishiko A, Dekio I, Fujimoto A, et al. Abnormal keratin expression in circumscribed palmar hypokeratosis. J Am Acad Dermatol. 2007;57:285–291.
Barry CI, Glusac EJ, Kashgarian M, Gwin K, McNiff JM. Circumscribed palmar hypokeratosis: two cases and a review of the literature. J Cutan Pathol. 2008;35:484–487.
Tanioka M, Miyagawa-Hayashino A, Manabe T, Toichi E, Miyachi Y, Takahashi K. Circumscribed palmo-plantar hypokeratosis: a disease with two subtypes. J Invest Dermatol. 2009;129:1045–1047.
Boffa MJ, Degaetano JS. Circumscribed palmar hypokeratosis: successful treatment with cryotherapy. J Eur Acad Dermatol Venereol. 2007;21:420–421.
Mensing CH, Schleusner VH, Sander CA, Mensing H. Circumscribed palmar or plantar hypokeratosis. Two cases of a recently described entity of unknown origin. Am J Dermatopathol. 2005;27:247–249.
Urbina F, Misad C, Gonzalez S. Circumscribed palmar hypokeratosis: clinical evolution and ultrastructural study after prolonged treatment with topical calcipotriol. J Eur Acad Dermatol Venereol. 2005;19:491–494.
Berk DR, Böer A, Bauschard FD, Hurt MA, Santa-Cruz DJ, Eisen AZ. Circumscribed acral hypokeratosis. J Am Acad Dermatol. 2007;57:292–296.
Kanitakis J, Lora V, Balme B, Roby J. Premalignant circumscribed palmar hypokeratosis: A new form of circumscribed palmar hypokeratosis? Case report and literature review. Dermatology. 2010;220:143–146.
Benoit S, Seitz CS, Hamm H, Vetter-Kauczok CS, Bröcker E-B. Circumscribed palmar hypokeratosis: partial remission by photodynamic therapy. Br J Dermatol. 2007;157:804–806.
Author information
Authors and Affiliations
Corresponding author
Additional information
To view enhanced content go to www.dermtherapy-open.com
This article is published with open access at Springerlink.com
Rights and permissions
Open Access This is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/2.0), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
About this article
Cite this article
Wilk, M., Zelger, B.G. & Zelger, B. Circumscribed palmar hypokeratosis: Successful treatment with fluorouracil cream. Dermatol Ther 1, 11–14 (2011). https://doi.org/10.1007/s13555-011-0002-2
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13555-011-0002-2