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Mitochondria — key roles in sepsis

Mitochondrie — rôles clés dans le sepsis

  • Enseignement Supérieur en Réanimation Fondamental
  • Published:
Réanimation

Abstract

The pathophysiological mechanisms underpinning the development of, and recovery from, sepsis-induced organ failure require further delineation. Mitochondrial dysfunction may well play a key role. This review will therefore consider mitochondria’s function in normal physiology, evidence linking bioenergetic alterations to organ dysfunction after severe and prolonged inflammation, and potential therapeutic strategies that may be applied.

Résumé

Au cours du sepsis, les mécanismes physiopathologiques sous-tendant le développement et la récupération des dysfonctions d’organe sont encore mal compris. La dysfonction mitochondriale pourrait jouer un rôle majeur. Cette mise au point décrit la physiologie normale des mitochondries, les arguments reliant l’altération bioénergétique mitochondriale aux dysfonctions d’organes après des périodes d’inflammation sévère et prolongée. Enfin, les perspectives thérapeutiques envisageables seront abordées.

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  1. Bloomsbury Institute of Intensive Care Medicine, Department of Medicine, University College London, London, UK

    S. Saeed & M. Singer

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  1. S. Saeed
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  2. M. Singer
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Correspondence to M. Singer.

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Cet article correspond à la conférence faite par l’auteur au congrès de la SRLF 2013 dans la session: Voies de recherche dans le sepsis.

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Saeed, S., Singer, M. Mitochondria — key roles in sepsis. Réanimation 22 (Suppl 2), 352–358 (2013). https://doi.org/10.1007/s13546-012-0638-7

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