Résumé
L’encéphalite aiguë reste une cause fréquente d’admission en réanimation pédiatrique. Bien que la majorité soit d’origine infectieuse, les encéphalites non infectieuses restent mal connues, leur diagnostic et leur traitement souvent retardés. Nous présentons ici les principales causes d’encéphalites aiguës non infectieuses comme l’encéphalomyélite aiguë disséminée, l’encéphalite liée au syndrome d’activation macrophagique, l’encéphalopathie d’Hashimoto, les encéphalites antirécepteurs de l’acide N-méthyl-D-aspartique (NMDA) et les fever-infection related epilepsy syndrome (FIRES)/devastating epilepsy in school-age children (DESC) syndrome.
Abstract
Acute encephalitis remains a frequent cause of admission in paediatric intensive care units. Although most cases are due to infective causes, non-infectious acute encephalitis is less well known and its diagnosis and treatment are frequently delayed. Hereby we describe the main causes of non-infectious acute encephalitis including acute disseminated encephalomyelitis, macrophage activation syndrome related acute encephalitis, Hashimoto encephalitis, anti-N-Methyl-D-aspartate (NMDA) receptor encephalitis and fever-infection related epilepsy syndrome (FIRES)/devastating epilepsy in school-age children (DESC) syndrome.
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Références
Jmor F, Emsley HC, Fischer M, et al (2008) The incidence of acute encephalitis syndrome in Western industrialised and tropical countries. Virol J 5:134
Mailles A, Stahl JP (2009) Infectious encephalitis in france in 2007: a national prospective study. Clin Infect Dis 49:1838–1847
Mikaeloff Y, Adamsbaum C, Husson B, et al (2004) MRI prognostic factors for relapse after acute CNS inflammatory demyelination in childhood. Brain 127:1942–1947
Dale RC, Brilot F, Banwell B (2009)Pediatric central nervous system inflammatory demyelination: acute disseminated encephalomyelitis, clinically isolated syndromes, neuromyelitis optica, and multiple sclerosis. Curr Opin Neurol 22:233–240
Krupp LB, Banwell B, Tenembaum S (2007) Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurology 68:S7–S12
Mikaeloff Y, Caridade G, Husson B, et al (2007) Acute disseminated encephalomyelitis cohort study: prognostic factors for relapse. Eur J Paediatr Neurol 11:90–95
Feldmann J, Menasche G, Callebaut I, et al (2005) Severe and progressive encephalitis as a presenting manifestation of a novel missense perforin mutation and impaired cytolytic activity. Blood 105:2658–2663
Deiva K, Mahlaoui N, Beaudonnet F, et al (2012) CNS involvement at the onset of primary hemophagocytic lymphohistiocytosis. Neurology 78:1150–1156
Ferracci F, Bertiato G, Moretto G (2004) Hashimoto’s encephalopathy: epidemiologic data and pathogenetic considerations. J Neurol Sci 217:165–168
Florance NR, Davis RL, Lam C, et al (2009) Anti-N-methyl-Daspartate receptor (NMDAR) encephalitis in children and adolescents. Ann Neurol 66:11–18
Hughes EG, Peng X, Gleichman AJ, et al (2010) Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis. J Neurosci 30:5866–5875
Dalmau J, Gleichman AJ, Hughes EG, et al (2008) Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 7:1091–1098
Gabilondo I, Saiz A, Galan L, et al (2011) Analysis of relapses in anti-NMDAR encephalitis. Neurology 77:996–999
Mikaeloff Y, Jambaque I, Hertz-Pannier L, et al (2006) Devastating epileptic encephalopathy in school-aged children (DESC): a pseudo encephalitis. Epilepsy Res 69:67–79
Kramer U, Chi CS, Lin KL, et al (2011) Febrile infection-related epilepsy syndrome (FIRES): pathogenesis, treatment, and outcome: a multicenter study on 77 children. Epilepsia 52:1956–1965
Vezzani A, Conti M, De Luigi A, et al (1999) Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures. J Neurosci 19:5054–5065
Vezzani A, French J, Bartfai T, Baram TZ (2011) The role of inflammation in epilepsy. Nat Rev Neurol 7:31–40
Chevret L, Husson B, Nguefack S, et al (2008) Prolonged refractory status epilepticus with early and persistent restricted hippocampal signal MRI abnormality. J Neurol 255:112–116
Nabbout R, Mazzuca M, Hubert P, et al (2010) Efficacy of ketogenic diet in severe refractory status epilepticus initiating fever induced refractory epileptic encephalopathy in school age children (FIRES). Epilepsia 51:2033–2037
Sakuma H, Awaya Y, Shiomi M, et al (2010) Acute encephalitis with refractory, repetitive partial seizures (AERRPS): a peculiar form of childhood encephalitis. Acta Neurol Scand 121:251–256
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Cet article correspond à la conférence faite par l’auteur au congrès de la SRLF 2013 dans la session: Pathologies inflammatoires graves de l’enfant.
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Deiva, K., Chevret, L. & Tissieres, P. Les encéphalites non infectieuses en réanimation pédiatrique. Réanimation 22 (Suppl 2), 397–402 (2013). https://doi.org/10.1007/s13546-012-0625-z
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DOI: https://doi.org/10.1007/s13546-012-0625-z