Skip to main content
Log in

Development and clinical translation of photoacoustic mammography

  • Review Article
  • Published:
Biomedical Engineering Letters Aims and scope Submit manuscript

Abstract

To practically apply photoacoustic (PA) imaging technology in medicine, we have developed prototypes of a photoacoustic mammography (PAM) device to acquire images for diagnosing breast cancer in the Kyoto University/Canon joint research project (CK project supported by MEXT, Japan). First, the basic ability of the PAM system to visualize the network of blood vessels and the Hb saturation index was evaluated using a prototype of PAM that has a flat scanning detector and is capable of simultaneously acquiring photoacoustic (PA) and ultrasound images. Next, another prototype of a PAM device with hemispherical sensors was developed to improve the visibility of the 3D structure of vessels by reducing the limited view effect. In clinical examination of breast cancer cases, the PAM system allowed 3D visualization of fine vessel networks with a spatial resolution of a half-millimeter and enabled us to determine the features of tumor-related vascular structures in human breast cancer. In addition, the oxygen saturation status of Hb was visualized using two different wavelengths, enabling more precise characterization of the tumor microenvironment. Results of clinical evaluation using our developed prototype of a PAM device confirmed that PA imaging technology has the potential to promote early detection of breast cancer, and realization of its practical use is expected in the near future.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Kim C, Favazza C, Wang LV. In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths. Chem Rev. 2010;110:2756–82.

    Article  Google Scholar 

  2. Kim J, et al. Programmable real-time clinical photoacoustic and ultrasound imaging system. Sci Rep. 2016;6:35137.

    Article  Google Scholar 

  3. Pogue BW, et al. Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value. Philos Trans R Soc A. 2011;369:4531–57.

    Article  Google Scholar 

  4. Quarto G, et al. Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography. Biomed Opt Express. 2014;5:3684–8.

    Article  Google Scholar 

  5. Viacava P, et al. Angiogenesis and VEGF expression in pre-invasive lesions of the human breast. J Pathol. 2004;204:140–6.

    Article  Google Scholar 

  6. Makris A, et al. Reduction in angiogenesis after neoadjuvant chemoendocrine therapy in patients with operable breast carcinoma. Cancer. 1999;85:1996–2000.

    Article  Google Scholar 

  7. Milani M, Harris AL. Targeting tumour hypoxia in breast cancer. Eur J Cancer. 2008;44:2766–73.

    Article  Google Scholar 

  8. Kitai T, et al. Photoacoustic mammography: initial clinical results. Breast Cancer. 2014;21(2):146–53.

    Article  Google Scholar 

  9. Fakhrejahani E, et al. Clinical report on the first prototype of a photoacoustic tomography system with dual illumination for breast cancer imaging. PLoS ONE. 2015;10:e0142287.

    Article  Google Scholar 

  10. Asao Y, et al. Photoacoustic mammography capable of simultaneously acquiring photoacoustic and ultrasound images. J Biomed Opt. 2016;21(11):116009.

    Article  Google Scholar 

  11. Kruger RA, et al. Dedicated 3D photoacoustic breast imaging. Med Phys. 2013;40:113301.

    Article  Google Scholar 

  12. Toi M, et al. Visualization of tumor-related blood vessels in human breast by photoacoustic imaging system with a hemispherical detector array. Sci Rep. 2017;7:41970.

    Article  Google Scholar 

  13. Matsumoto Y, et al. Label-free photoacoustic imaging of human palmar vessels: a structural morphological analysis. Sci Rep. 2018;8:786.

    Article  Google Scholar 

  14. Zhang HF, et al. Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging. Nat Biotechnol. 2006;24(7):848.

    Article  Google Scholar 

  15. Wang X, et al. Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography. J Biomed Opt. 2006;11(2):024015.

    Article  MathSciNet  Google Scholar 

  16. Wygant O, et al. Integration of 2D CMUT arrays with front-end electronics for volumetric ultrasound imaging. IEEE Trans Ultrason Ferroelectr Freq Control. 2008;55:327–42.

    Article  Google Scholar 

  17. Fukutani K, et al. Characterization of photoacoustic tomography system with dual illumination. Proc SPIE. 2011;7899:78992J.

    Article  Google Scholar 

  18. Xu M, Wang LV. Universal back-projection algorithm for photoacoustic computed tomography. Phys Rev E. 2005. https://doi.org/10.1103/physreve.71.016706.

    Google Scholar 

  19. Sederberg TW. Free-form deformation of solid geometric models. Proc SIGGRAPH’86. 1986;20(4):151–60.

    Article  Google Scholar 

  20. Home page of the ImPACT program, Cabinet Office in Japan; http://www.jst.go.jp/impact/program/10.htm.

  21. Shiina T. Innovative photoacoustic imaging technology to support vascular health science. In: Proceedings of CLEO 2016, ATh4N.3; 2016.

  22. Meng J, Wang LV, Ying L, Liang D, Song L. Compressed-sensing photoacoustic computed tomography in vivo with partially known support. Opt Express. 2012;20(15):16510–23.

    Article  Google Scholar 

  23. Xia J, Danielli A, Liu Y, Wang L, Maslov K, Wang LV. Calibration-free quantification of absolute oxygen saturation based on the dynamics of photoacoustic signals. Opt Lett. 2013;38(15):2800–3.

    Article  Google Scholar 

Download references

Acknowledgements

The authors thank all members of the CK project at Kyoto University Hospital and Canon, Inc., for collaboration of PAM research and analyzing clinical data.

Funding

This study was funded by the CK project “Innovative Techno-hub for Integrated Medical Bio-imaging” supported by the Ministry of Education, Culture, Sports, Science, and Technology, Japan, and the ImPACT Program “Innovative visualization technology to create a new growth industry” supported by the Council for Science, Technology and Innovation, Cabinet Office, Japan.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tsuyoshi Shiina.

Ethics declarations

Conflict of interest

Takayuki Yagi is an employee of Canon Inc., Japan and temporarily transferred to the Japan Science and Technology Agency. Canon Inc. designed and invented the photoacoustic mammography system used in this study. The other authors have no conflict of interest.

Ethical approval

The present study was approved by the Ethics Committee of the Kyoto University Graduate School of Medicine. This study was conducted in accordance with the Declaration of Helsinki.

Informed consent

Written informed consent was obtained from all participants included in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shiina, T., Toi, M. & Yagi, T. Development and clinical translation of photoacoustic mammography. Biomed. Eng. Lett. 8, 157–165 (2018). https://doi.org/10.1007/s13534-018-0070-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13534-018-0070-7

Keywords

Navigation