Skip to main content
SpringerLink
Log in

Analysis of force acting on the non-spherical particle near a wall

  • Original Article
  • Published:
Biomedical Engineering Letters Aims and scope Submit manuscript

Abstract

Purpose

To investigate the non-spherical particle dynamics near a wall in a vasculature, it is required that detailed force with respect to the particle angle and separation distance. The prismatic particles with different cross sections are employed to study the forces on the particle in linear shear flow.

Methods

The force on the particle at the proximity of the wall in linear shear flow is evaluated. Fluid dynamics simulation is performed by using Fluent software. To investigate the effect of particle non-sphericity, triangular, rectangular and hexagonal prisms are considered.

Results

As the particle places close to the wall, the interaction between particle and wall increase. Due to the particle nonsphericity, the periodic force fluctuation is observed and this feature is important as the particle approaches to the wall. The number of apex of the cross sectional geometry is significant on the force on the particle by fluid.

Conclusions

The interaction between particle and the wall induces force imbalance so that it is predicted that the particle geometry will influence on the particle dynamics in the vascular flow. The particle cross sectional shape and particle non-sphericity are important factors in designing particlebased drug delivery system.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Champion JA, Katare YK, Mitragotri S. Making polymeric micro- and nanoparticles of complex shapes. Proc Natl Acad Sci USA. 2007; 104(29):11901–4.

    Article  Google Scholar 

  2. Gratton SE, Pohlhaus PD, Lee J, Guo J, Cho MJ, Desimone JM. Nanofabricated particles for engineered drug therapies: a preliminary biodistribution study of PRINT nanoparticles. J Control Release. 2007; 121(1):2–10.

    Google Scholar 

  3. Piao Y, Jang Y, Shokouhimehr M, Lee IS, Hyeon T. Facile aqueous-phase synthesis of uniform palladium nanoparticles of various shapes and sizes. Small. 2007; 3(2):255–60.

    Article  Google Scholar 

  4. Tasciotti E, Liu X, Bhavane R, Plant K, Leonard AD, Price BK, Cheng MM, Decuzzi P, Tour JM, Robertson F, Ferrari M. Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. Nat Nanotechnol. 2008; 3:151–7.

    Article  Google Scholar 

  5. Ferrari M. Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer. 2005; 5(3):161–71.

    Article  Google Scholar 

  6. Decuzzi P, Pasqualini R, Arap W, Ferrari M. Intravascular Delivery of Particulate Systems: Does Geometry Really Matter? Pharm Res. 2009; 26(1):235–43.

    Article  Google Scholar 

  7. Goldman AJ, Cox RG, Brenner H. Slow viscous motion of a sphere parallel to a plane wall - I Motion in a quiescent fluid. Chem Eng Sci. 1967; 22(4):637–51.

    Article  Google Scholar 

  8. Goldman AJ, Cox RG, Brenner H. Slow viscous motion of a sphere parallel to a plane wall - II Couette flow. Chem Eng Sci. 1967; 22(4):653–60.

    Article  Google Scholar 

  9. Jeffery GB. The motion of ellipsoidal particles immersed in a viscous fluid. Proc R Soc Lond A. 1922; 102(715):161–79.

    Article  MATH  Google Scholar 

  10. Gavze E, Shapiro M. Particles in a shear flow near a solid wall: effect of nonsphericity on forces and velocities. Int J Multiphase Flow. 1997; 23(1):155–82.

    Article  MATH  Google Scholar 

  11. Gavze E, Shapiro M. Motion of inertial spheroidal particles in a shear flow near a solid wall with special application to aerosol transport in microgravity. J Fluid Mech. 1998; 371:59–79.

    Article  MATH  Google Scholar 

  12. Broday D, Fichman M, Shapiro M, Gutfinger C. Motion of spheroidal particles in vertical shear flows. Phys Fluids. 1998; 10(1):80–100.

    Article  MathSciNet  MATH  Google Scholar 

  13. Lee SY, Ferrari M, Decuzzi P. Design of bio-mimetic particles with enhanced vascular interaction. J Biomech. 2009; 42(12):1885–90.

    Article  Google Scholar 

  14. Lee SY, Ferrari M, Decuzzi P. Shaping nano-/micro-particles for enhanced vascular interaction in laminar flows. Nanotechnology. 2009; doi: 10.1088/0957-4484/20/49/495101.

    Google Scholar 

  15. Decuzzi P, Ferrari M. The adhesive strength of non-spherical particles mediated by specific interactions. Biomaterials. 2006; 27(30):5307–14.

    Article  Google Scholar 

  16. Decuzzi P, Ferrari M. Design maps for nanoparticles targeting the diseased microvasculature. Biomaterials. 2008; 29(3):377–84.

    Article  Google Scholar 

  17. Gentile F, Chiappini C, Fine D, Bhavane RC, Peluccio MS, Cheng MM, Liu X, Ferrari M, Decuzzi P. The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows. J Biomech. 2008; 41(10):2312–8.

    Article  Google Scholar 

  18. Adriani G, de Tullio MD, Ferrari M, Hussain F, Pascazio G, Liu X, Decuzzi P. The preferential targeting of the diseased microvasculature by disk-like particles. Biomaterials. 2012; 33(22):5504–13.

    Article  Google Scholar 

  19. Lee SY, Zaske AM, Novellino T, Danila D, Ferrari M, Conyers J, Decuzzi P. Probing the mechanical properties of TNF-alpha stimulated endothelial cell with atomic force microscopy. Int J Nanomedicine. 2011; 6:179–95.

    Article  Google Scholar 

  20. Boso DP, Lee SY, Ferrari M, Schrefler BA, Decuzzi P. Optimizing particle size for targeting diseased microvasculature: from experiments to artificial neural networks. Int J Nanomedicine. 2011; 6:1517–26.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biomedical Engineering, Yonsei University, Wonju, Kangwon, Republic of Korea

    Sei Young Lee & Ji Yeon Hyun

Authors
  1. Sei Young Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ji Yeon Hyun
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sei Young Lee.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lee, S.Y., Hyun, J.Y. Analysis of force acting on the non-spherical particle near a wall. Biomed. Eng. Lett. 5, 289–295 (2015). https://doi.org/10.1007/s13534-015-0205-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13534-015-0205-z

Keywords

Search

Navigation