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Forming vascular networks within functional cardiac tissue constructs

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Abstract

Over the years much has been attempted to generate engineered cardiac tissue. One approach is culturing cells within engineered biodegradable scaffolds to provide temporary elastic support and to replace the necrotic cardiomyocytes. In particular, these engineered tissue construct have been of great interest as an implantable patch over a region of the myocardial infarct to stimulate the formation of micro-vessel growth and thus increase blood flow through the myocardium. For the successful revascularization after myocardial infarction, vascularization within three-dimensional engineered cardiac tissue construct has become important for stimulating the formation of a mature microvascular network. In this review, various approaches and recent advances in vascularization of engineered cardiac patch are highlighted and discussed.

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Authors and Affiliations

  1. College of Life Sciences and Biotechnology, Korea University, 5-Ka, Anam-Dong, Sungbuk-Ku, Seoul, 136-701, Korea

    Hanna Lee

  2. College of Animal Bioscience and Technology, Department of Bioindustrial Technologies, Konkuk University, Hwayang-dong, Kwangjin-gu, Seoul, 143-701, Korea

    Hojae Bae

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Correspondence to Hojae Bae.

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Lee, H., Bae, H. Forming vascular networks within functional cardiac tissue constructs. Biomed. Eng. Lett. 3, 138–143 (2013). https://doi.org/10.1007/s13534-013-0106-y

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  • DOI: https://doi.org/10.1007/s13534-013-0106-y

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