Abstract
Objective
Cardiovascular diseases (CVD) are the primary cause of death worldwide. Therefore, this investigation aimed to evaluate the effect of arsenic exposure and genetic polymorphism (rs1800469) on cardiovascular risk biomarkers levels in a Mexican adult population.
Methods
Then, a cross-sectional study was completed, including 155 adults. Urinary arsenic (UAs) levels were analyzed as an exposure biomarker, and assessed cardiovascular risk biomarkers were: serum ADMA and FABP4 concentrations and atherogenic indices (Castelli risk index and atherogenic index of plasma). Gentrification of TGF-β C509T polymorphism (rs1800469) was determined by real-time polymerase chain reaction (PCR) using TaqMan probes.
Results
UAs levels ranged from 11.5 to 175 µg/g creatinine. The allele frequency for TGF-β C509T polymorphism was 0.37 and 0.63 for the C and T alleles, respectively. Mean serum ADMA and FABP4 levels were 1.35 ± 0.35 µmol/L and 22.0 ± 9.50 ng/mL, respectively. Also, statistically significant associations (p < 0.05) were detected between the exposure biomarker (UAs) and the cardiovascular risk biomarkers (ADMA and FABP4). Similarly, a strong relationship was detected between the TGF-β C509T polymorphism and assessed cardiovascular risk biomarkers (ADMA and FABP4). In addition, a gene-environmental interaction was found.
Conclusion
Our findings suggest a gene-environment interaction with an enhanced effect on CVD biomarkers.
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Acknowledgements
The authors show appreciation to all the people contributing to the research who facilitated us in conducting this study. Principally, we are grateful to the participants for their consent.
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Alejandra González-Bravo, Myrna Lizbeth López-Ramírez, Ángeles C. Ochoa-Martínez, Leticia Carrizales-Yáñez, and Salvado I. Martinez-Bernal. The first draft of the manuscript was written by Ivan N. Pérez-Maldonado. All authors read and approved the final manuscript. This project was funded by the CONACYT (Consejo Nacional de Ciencia y Tecnología México). FORDECYT. Grant No. 309519.
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Alejandra González‑Bravo, Myrna L. López‑Ramírez, Ángeles C. Ochoa‑Martínez, Leticia Carrizales‑Yáñez, Salvador I. Martínez‑Bernal and Ivan N. Perez‑Maldonado declare that we have no conflict of interest.
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The bioethics committee of the Secretary of Health of the State of San Luis Potosi analyzed and approved the execution of this research. Also, enrolled individuals signed informed consent of voluntary participation.
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González-Bravo, A., López-Ramírez, M.L., Ochoa-Martínez, Á.C. et al. Influence of arsenic exposure and TGF-β gene single nucleotide polymorphisms (gene-environment interaction) on cardiovascular risk biomarkers levels in Mexican people from San Luis Potosi, Mexico. Toxicol. Environ. Health Sci. (2024). https://doi.org/10.1007/s13530-024-00206-y
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DOI: https://doi.org/10.1007/s13530-024-00206-y