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Thorium Harmful Impacts on the Physiological Parameters of the Adult Male Albino Rats and Their Mitigation Using the Alginate

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Abstract

Objective

Thorium-232 is a natural radionuclide from the actinide family, is abundantly present in monazite and other ores after thorium occupational or accidental exposures it deposited in many organs. The object of the study is to investigate thorium shortterm hazards effects on the male albino rate and study the alginate mitigation effect on thorium hazards.

Methods

Rats were grouped into control, Thorium (Th) and Th+Alginate(Alg) groups. The 54 rats of the different groups were decapitated (6 rats for each decapitation) after the 1st, 3rd, and 7th day during the treatment. Parameters of hematological (Hb, RBCs, indices, granular, lymphocytes), liver (GOT, GPT, Alb.), lipid (chol., trig.) kidney (creat., urea, uric acid) were determined after the determination of thorium distribution and accumulation in different organs.

Results

The results showed that the IP administration of 13.6 mg/kg b.wt. thorium nitrate (Th) for seven days produced an organs distribution of Th and accumulated in liver>brain>lipid>Kidney>heart>testes at the end of the experiment, also it induced a hematological, hepatic and lipid dysfunction with no effect on renal function. On the other hand, the oral administration of 5% alginate in the drinking water in parallel with Th injection could slightly reduce Th hazardous effects which may be due to alginate ability to inhibit many inflammatory factors that reduce the hemolysis in erythrocyte, reduce hepatocellular apoptosis, enhance the cholesterol excretion into the feces and also due to the antioxidant and chelating capacity of alginate to Th ions.

Conclusion

So, alginate administration could ameliorate Th short-term hazards effects.

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Authors and Affiliations

  1. Isotopes department, Nuclear materials authority, Cairo, Egypt

    Mohamed M. Rezk

  2. Medical & Radiation Research Department Nuclear Materials Authority, Cairo, Egypt

    Asmaa A. Mohamed & Amal A. Ammar

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  1. Mohamed M. Rezk
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Correspondence to Mohamed M. Rezk.

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Rezk, M.M., Mohamed, A.A. & Ammar, A.A. Thorium Harmful Impacts on the Physiological Parameters of the Adult Male Albino Rats and Their Mitigation Using the Alginate. Toxicol. Environ. Health Sci. 10, 253–260 (2018). https://doi.org/10.1007/s13530-018-0373-1

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