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Lactic Acid Bacteria Isolated from Kimchi to Evaluate Anti-obesity Effect in High Fat Diet-induced Obese Mice

  • Soo Youn Lee
  • Simranjeet Singh Sekhon
  • Jung Ho Ko
  • Hyung Cheol Kim
  • Sang Yong Kim
  • Kyungho Won
  • Ji-Young Ahn
  • Kibeom Lee
  • Yang-Hoon Kim
Rapid communication
  • 51 Downloads

Abstract

Obesity is one of the major public concerns due to its various side-effects such as metabolic and chronic ailments. In this study, two lactic acid bacteria (LAB) strains, Leuconostoc mesenteroides and Lactobacillus sakei, isolated from Kimchi were investigated for their anti-obesity activity in obese mice model. To induce obesity in model mice (C57BL/6), high fat diet (HFD) with 60 kcal% fat was fed for 10 weeks. LAB supplementation reduced blood urea nitrogen, glucose, and triglyceride levels in serum from obesity induced mice. The study also observed significant decrease of fibrosis, triglyceride, and total cholesterol level in fatty liver tissue by LAB supplementation. The results suggest that supplementation of L. mesenteroides and L. sakei could be used as alternative nutritional interventions to decrease symptoms caused by obesity with no safety or intolerance related problem.

Keywords

Lactic acid bacteria obese mice Anti-obesity LAB supplementation 

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References

  1. 1.
    Formiguera, X. & Cantón, A. Obesity: epidemiology and clinical aspects. Best Pract. Res. Clin. Gastroenterol. 18, 1125–1146 (2004).CrossRefPubMedGoogle Scholar
  2. 2.
    Kopelman, P. G. Obesity as a medical problem. Nature 404, 635–643 (2000).CrossRefPubMedGoogle Scholar
  3. 3.
    Cawley, J. & Meyerhoefer, C. The medical care costs of obesity: an instrumental variables approach. J. Health Econ. 31, 219–230 (2012).CrossRefPubMedGoogle Scholar
  4. 4.
    Kim, M. J. et al. The effects of kimchi on hematological and immunological parameters in vivo and in vitro. J. Korean Soc. Food Sci. Nutr. 26, 1208–1214 (1997).Google Scholar
  5. 5.
    Wu, A. H. et al. A meta-analysis of soy foods and risk of stomach cancer: the problem of potential confounder. Cancer Epidemiol. Biomarkers. Prev. 9, 1051–1058 (2000).PubMedGoogle Scholar
  6. 6.
    Yoon, J. Y. et al. Antiobesity effect of baek-kimchi (whitish baechu kimchi) in rats fed high fat diet. Prev. Nutr. Food Sci. 9, 259–264 (2004).CrossRefGoogle Scholar
  7. 7.
    Han, W. et al. Anti-cancer activity of human colon cancer (HT-29) cellline from different fraction of Zanthoxylum schnifolium fruits. Korean J. Pharmacogn. 42, 282–287 (2011).Google Scholar
  8. 8.
    Park, K. Y. et al. Health benefits of kimchi (Korean fermented vegetables) as a probiotic food. J. Med. Food 17, 6–20 (2014).CrossRefPubMedGoogle Scholar
  9. 9.
    Lee, J. S. et al. Classification of isolates originating from kimchi using carbon-source utilization patterns. J. Microbiol. Biotechnol. 7, 68–74 (1997).Google Scholar
  10. 10.
    Kim, N. H. et al. Lipid profile lowering effect of Soypro TM fermented with lactic acid bacteria isolated from Kimchi in high-fat diet-induced obese rats. Bio-Factors 33, 49–60 (2008).Google Scholar
  11. 11.
    Jung, J. Y. et al. Metagenomic analysis of kimchi, a traditional Korean fermented food. Appl. Environ. Microbiol. 77, 2264–2274 (2011).CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Abdennour, M. et al. Association of adipose tissue and liver fibrosis with tissue stiffness in morbid obesity: links with diabetes and BMI loss after gastric bypass. J. Clin. Endocrinol. Metab. 99, 898–907 (2014).CrossRefPubMedGoogle Scholar
  13. 13.
    Adolfsson, O. et al. Yogurt and gut function. Am. J. Clin. Nutr. 80, 245–256 (2004).CrossRefPubMedGoogle Scholar
  14. 14.
    Park. J.-E. et al. Lactobacillus plantarum LG42 isolated from gajami sik-hae decreases body and fat pad weights in diet-induced obese mice. J. Appl. Microbiol. 116, 145–156 (2014).CrossRefPubMedGoogle Scholar
  15. 15.
    Hong, S.-M. et al. Anti-obesity effect of fermented whey beverage using lactic acid bacteria in diet-induced obese rats. Korean J. Food Sci. Anim. Resour. 35, 653–659 (2015).CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Climate Change Research DivisionKorea Institute of Energy ResearchDaejeonRepublic of Korea
  2. 2.School of Biological SciencesChungbuk National UniversityCheongjuRepublic of Korea
  3. 3.College of Veterinary MedicineWestern University of Health SciencesPomonaUSA
  4. 4.Technology Transfer CenterKorea Research Institute of Bioscience and BiotechnologyDaejeonRepublic of Korea
  5. 5.Department of Food Science & BiotechnologyShin Ansan UniversityAnsanRepublic of Korea
  6. 6.Pear Research Institute, National Institute of Horticultural & Herbal ScienceRural Development AdministrationNajuRepublic of Korea
  7. 7.Biotechnology & Business CenterIncheon TechnoparkIncheonRepublic of Korea

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