Lactic Acid Bacteria Isolated from Kimchi to Evaluate Anti-obesity Effect in High Fat Diet-induced Obese Mice

  • Soo Youn Lee
  • Simranjeet Singh Sekhon
  • Jung Ho Ko
  • Hyung Cheol Kim
  • Sang Yong Kim
  • Kyungho Won
  • Ji-Young AhnEmail author
  • Kibeom LeeEmail author
  • Yang-Hoon KimEmail author
Rapid communication


Obesity is one of the major public concerns due to its various side-effects such as metabolic and chronic ailments. In this study, two lactic acid bacteria (LAB) strains, Leuconostoc mesenteroides and Lactobacillus sakei, isolated from Kimchi were investigated for their anti-obesity activity in obese mice model. To induce obesity in model mice (C57BL/6), high fat diet (HFD) with 60 kcal% fat was fed for 10 weeks. LAB supplementation reduced blood urea nitrogen, glucose, and triglyceride levels in serum from obesity induced mice. The study also observed significant decrease of fibrosis, triglyceride, and total cholesterol level in fatty liver tissue by LAB supplementation. The results suggest that supplementation of L. mesenteroides and L. sakei could be used as alternative nutritional interventions to decrease symptoms caused by obesity with no safety or intolerance related problem.


Lactic acid bacteria obese mice Anti-obesity LAB supplementation 


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© Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Climate Change Research DivisionKorea Institute of Energy ResearchDaejeonRepublic of Korea
  2. 2.School of Biological SciencesChungbuk National UniversityCheongjuRepublic of Korea
  3. 3.College of Veterinary MedicineWestern University of Health SciencesPomonaUSA
  4. 4.Technology Transfer CenterKorea Research Institute of Bioscience and BiotechnologyDaejeonRepublic of Korea
  5. 5.Department of Food Science & BiotechnologyShin Ansan UniversityAnsanRepublic of Korea
  6. 6.Pear Research Institute, National Institute of Horticultural & Herbal ScienceRural Development AdministrationNajuRepublic of Korea
  7. 7.Biotechnology & Business CenterIncheon TechnoparkIncheonRepublic of Korea

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