Photodynamic therapy (PDT) is a treatment method based on irradiating the affected tissue with a light of suitable wavelength in the presence of a photosensitizer and O2, which generates reactive oxygen species via excitation of the photosensitizer resulting in the desired therapeutic effect. PDT has been clinically applied for the treatment of cancers and non-neoplastic diseases. Chlorin e6 (Ce6) is a promising representative of the chlorin platform photosensitizer with diverse variants. In this investigation, the photosensitizing effect of Ce6 and Tin-Ce6 was compared in vitro in the presence of halogen light, focusing on their antibacterial and anti-inflammatory effects. In conclusion, Ce6 was more effective than Tin-Ce6 in controlling the growth of microorganisms which reside on the skin and inflammatory molecules of the LPS-induced inflammatory response.
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Jin, S., Ryu, AR., Han, CS. et al. A comparison of the anti-bacterial and anti-inflammatory effect between two forms of chlorins. Toxicol. Environ. Health Sci. 8, 271–276 (2016). https://doi.org/10.1007/s13530-016-0285-x
- Photodynamic therapy