There have been studied on therapeutic of anticancer and antimicrobial using by effective proteins or peptides. In this study, we examined the lysosomal membrane protein extracted from lysosomes isolated from melanocyte treated by melanin with 100 ppm for 24 hours in order to find them reacted to targeting ability to melanin using by 2-dimensional electrophoresis (2DE). Consequently, we found 29 up-regulated (2.0 fold) and 23 down-regulated (2.0 fold) spots associated with melanin treatment. This result shown that lysosomal membrane proteins have function to react to treatment or decrease of melanin quantity through cellular activation of lysosomes.
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Bang, S.H., Park, D.J., Kim, YH. et al. Lysosomal membrane proteins exposed to melanin in melanocyte B16F10. Toxicol. Environ. Health Sci. 8, 253–257 (2016). https://doi.org/10.1007/s13530-016-0282-0