Photodynamic inactivation (PDI) is based on the utilization of a photosensitizer with light source and oxygen, producing reactive oxygen species which inactivate microbes and fungi. In this study, the antimicrobial effect of PDI using chlorin e6 (Ce6) and halogen light was investigated against several microbes and fungus with different properties. The PDI effects were tested against two gram-positive bacteria, S. aureus and B. subtilis, and one gram-negative bacterium E. coli. The acne-causing P. acnes, opportunistic oral and genital pathogen C. albicans and main contributor to tooth decay of S. mutans were also used for PDI test. Notably, Ce6-mediated PDI showed superior in vitro anti-pathogenic effects on P. acnes, S. mutans, and C. albicans in this study.
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Ryu, AR., Han, CS., Oh, HK. et al. Chlorin e6-mediated photodynamic inactivation with halogen light against microbes and fungus. Toxicol. Environ. Health Sci. 7, 231–238 (2015). https://doi.org/10.1007/s13530-015-0243-z
- Chlorin e6
- Halogen light
- Photodynamic inactivation